A case of post-hepatitis B cirrhosis complicated by hepatic myelopathy
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摘要: <正>肝性脊髓病(hepatic myelopathy,HM)为肝硬化晚期一种罕见的神经系统并发症,临床上主要以缓慢进行性痉挛性截瘫为特征性表现,一般仅累及双下肢,上肢通常免疫或最低限度受影响。其组织病理学改变为皮质脊髓侧索对称性脱髓鞘,全脊髓均可见,以胸、腰段最为明显[1]。有少量的HM主要通过影响颈髓,从而引起四肢麻痹[2]。由于该病发病率低,预后差,且临床工作者对该病的发病机制、诊断及治疗仍不十分清
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Key words:
- liver cirrhosis /
- hepatic myelopathy /
- case reports
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[1] UPTON MP, PAI RK, VIETH M, et al.Esophageal disease and pathology[J].Ann N Y Acad Sci, 2011, 1232 (4) :376-380. [2] KORI P, SAHU R, JAISWAL A, et al.Hepatic myelopathy:an unusual neurological complication of chronic liver disease presenting as quadriparesis[J].BMJ Case Rep, 2013, pii:bcr2013009078. [3]LEIGH AD, CARD WI.Hepato-lenticular degeneration;a case associated with postero-lateral column degeneration[J].J Neuropathol Exp Neurol, 1949, 8 (3) :338-346. [4] Internal Medicine and Neurology Group, Tangshan Workers'Hospital of Hebei.Cirrhosis associated with spinal cord lesions:two cases report[J].New Chin Med, 1976, 2 (2) :107-108. (in Chinese) 河北唐山工人医院内科神经病小组.肝硬变伴发脊髓病变2例报道[J].新医学, 1976, 2 (2) :107-108. [5]NARDONE R, HLLER Y, STORTI M, et al.Spinal cord involvement in patients with cirrhosis[J].World J Gastroenterol, 2014, 20 (10) :2578-2585. [6]WANG XP, LI WH.Two cases of hepatic myelopathy and literature review[J].China Prac Med, 2014, 9 (3) :194-195. (in Chinese) 王小平, 李文辉.肝性脊髓病2例报告并文献复习[J].中国实用医药, 2014, 9 (3) :194-195. [7]CHEN ZH, CHEN DF.Progress of hepatic myelopathy[J].Chin J Gastroenterol Hepatol, 2016, 25 (7) :832-834. (in Chinese) 陈志惠, 陈东风.肝性脊髓病研究进展[J].胃肠病学和肝病学杂志, 2016, 25 (7) :832-834. [8]BOYER TD, HASKAL ZJ, American Association for the Study of Liver Diseases.The role of transjugular intrahepatic portosystemic shunt (TIPS) in the management of portal hypertension:update2009[J].Hepatology, 2010, 51 (1) :306. [9] BUDILLON G, MANSI D, SCALA G, et al.“Hepatic paraplegia”:an uncommon complication of portosystemic shunt[J].Acta Neurol (Napoli) , 1979, 1 (2) :93-100. [10]GIANGASPERO F, DONDI C, SCARANI P, et al.Degeneration of the corticospinal tract following portosystemic shunt associated with spinal cord infarction[J].Virchows Arch A Pathol Anat Histopathol, 1985, 406 (4) :475-481. [11]WANG HB, LIU ZW.Research advances in hepatic myelopathy[J].J Pract Hepatol, 2009, 12 (5) :393-396. (in Chinese) 王洪波, 刘振文.肝性脊髓病研究新进展[J].实用肝脏病杂志, 2009, 12 (5) :393-396. [12]YANG Y, YANG L.Research progress in hepatic myelopathy[J].J Clin Hepatol, 2015, 31 (12) :2097-2099. (in Chinese) 杨阳, 杨龙.肝性脊髓病研究进展[J].临床肝胆病杂志, 2015, 31 (12) :2097-2099. [13]WEISSENBORN K, TIETGE UJ, BOKEMEYER M, et al.Liver transplantation improves hepatic myelopathy:evidence by three cases[J].Gastroenterology, 2003, 124 (2) :346-351. [14]UTKU U, ASIL T, BALCI K, et al.Hepatic myelopathy with spastic paraparesis[J].Clin Neurol Neurosurg, 2005, 107 (6) :514-516. [15] COUNSELL C, WARLOW C.Failure of presumed hepatic myelopathy to improve after liver transplantation[J].Neurol Neurosurg Psychiatry, 1996, 60 (5) :590. [16] TROISI R, DEBRUYNE J, de HEMPTINNE B.Improvement of hepatic myelopathy after liver transplantation[J].N Engl J Med, 1999, 340 (2) :151. [17]NARDONE R, GOLASZEWSKI S, HLLER Y, et al.Letter to the editor concerning“hepatic myelopathy with spastic paraparesis:report of two cases and review of the literature”by S.Ben Amor et al. (Eur Spine J.2013, Jun 1) [J].Eur Spine J, 2013, 22 (10) :2340.
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