IgG4-negative autoimmune pancreatitis: a report of 2 cases and literature review
-
摘要: <正>自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是一种炎症组织中伴IgG4阳性淋巴细胞和浆细胞浸润,血清IgG4水平升高的自身免疫相关特殊类型慢性胰腺炎,AIP发病率较低,约占慢性胰腺炎的4%6%,发病率约为0.82/10万[1],其特点为胰腺弥漫性肿大,胰管和胆管狭窄,胰腺不同程度的内分泌或外分泌功能异常,伴有血清免疫学指标IgG4阳性,胰腺组织病理学表现为弥漫性纤维化及淋巴细胞、浆细胞浸润。
-
Key words:
- immunoglobulin G /
- pancreatitis /
- case reports
-
[1]DING YX, BAI XW, WANG G, et al.Research advances in autoimmune pancreatitis[J].Chin J Hepatobiliary Surg, 2014, 20 (11) :837-840. (in Chinese) 丁乙轩, 白雪巍, 王刚, 等.自身免疫性胰腺炎的研究进展[J].中华肝胆外科杂志, 2014, 20 (11) :837-840. [2]YIN T, WU HS.Progress in diagnosis and treatment of autoimmune pancreatitis[J].J Clin Hepatol, 2015, 31 (5) :665-667. (in Chinese) 殷涛, 吴河水.自身免疫性胰腺炎的诊治进展[J].临床肝胆病杂志, 2015, 31 (5) :665-667. [3]van HEERDE MJ, BUIJS J, RAUWS EA, et al.A comparative study of diagnostic scoring systems for autoimmune pancreatitis[J].Pancreas, 2014, 43 (4) :559-564. [4]CHINTANABOINA JK, PATEL BK, LALOSB AT, et al.Autoimmune pancreatitis presenting as a focal pancreatic mass mimicking pancreatic cancer:a case report and review of the literature[J].JMed Cases, 2013, 4 (1) :29-33. [5]MA XX, SHI HP, SUN P, et al.CT perfusion imaging of type IIautoimmune pancreatitis[J].Diagn Imag Interv Radiol, 2015, 24 (1) :5-8. (in Chinese) 马晓璇, 时惠平, 孙鹏, 等.II型自身免疫性胰腺炎的CT灌注成像研究[J].影像诊断与介入放射学, 2015, 24 (1) :5-8. [6]ZHANG AY, CHEN H, ZHAO P, et al.Differential diagnosis of autoimmune pancreatitis from pancreatic cancer[J].J Clin Hepatol, 2015, 31 (5) :783-786. (in Chinese) 张安元, 陈浩, 赵鹏, 等.自身免疫性胰腺炎与胰腺癌的鉴别诊断[J].临床肝胆病杂志, 2015, 31 (5) :783-786. [7]MOON SH, KIM MH, PARK DH, et al.Is a 2-week steroid trial after initial negative investigation for malignancy useful in differentiating autoimmune panereatitis from pancreatic cancer?A prospective outcome study[J].Gut, 2008, 57 (12) :1704-1712. [8]KAMISAWA T, SHIMOSEGAWA T, OKAZAKI K, et al.Standardsteroid treatment for autoimmune pancreatitis[J].Gut, 2009, 58 (11) :1504-1507. [9]KAMISAWA T, OKAMOTO A, WAKABAYASHI T.et al.Appropriate steroid therapy for autoimmune pancreatitis based on longterm outcome[J].Scand J Gastroenterol, 2008, 43 (5) :609-613. [10]HIRANO K, TADA M, ISAYAMA H, et al.Long-term prognosis of autoimmune pancreatitis with and without corticosteroid treatment[J].Gut, 2007, 56 (12) :1719-1724. [11]ITO T, NISHIMOFI I, INOUE N, et al.Treatment for autoimmune pancreatitis;consensus on the treatment for patients with autoimmune pancreatitis in Japan[J].J Gastroenterol, 2007, 42 (Suppl 18) :50-58. [12] WANG CL, YANG Y, JIANG Y, et al.A case of type II autoimmune pancreatitis with mass in the head of the pancreas[J].Chin JHepatobiliary Surg, 2016, 22 (2) :102-106. (in Chinese) 王成林, 杨雨, 江勇, 等.II型胰头肿块型自身免疫性胰腺炎一例[J].中华肝胆外科杂志, 2016, 22 (2) :102-106.
本文二维码
计量
- 文章访问数: 1877
- HTML全文浏览量: 5
- PDF下载量: 455
- 被引次数: 0