DNA识别受体在乙型肝炎发病机制中的作用

黄劲; 庞秀青; 谢冬英

doi:10.3969/j.issn.1001-5256.2017.09.037

DNA识别受体在乙型肝炎发病机制中的作用

DOI: 10.3969/j.issn.1001-5256.2017.09.037

中山大学附属第三医院肝病实验室

基金项目:

广东省自然科学基金项目(2015A030313022)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2017-09-20

Role of DNA recognition receptors in pathogenic mechanism of hepatitis B

Hepatopathy Laboratory, The Third Affiliated Hospital of Sun Yat-Sen University

Research funding:

摘要

摘要: 乙型肝炎作为一种全球性疾病至今仍危害着人类健康,但是HBV导致的肝炎发病机制仍未明确。肝脏中的固有免疫系统能监测HBV感染,并且运用各种策略清除病毒,其中DNA识别受体发挥了重要的作用。DNA识别受体在胞质或者胞核中识别HBV DNA或pgRNA,通过各种信号通路激活固有免疫从而产生炎性因子及IFN,最终发挥抗病毒作用。总结了各种参与HBV致炎及HBV清除的DNA识别受体,阐述了它们的具体作用途径,并对DNA识别受体在HBV诱导的肝脏固有免疫作用中存在的问题作出讨论及展望。
- 肝炎,乙型 /
- 受体,模式识别 /
- 综述
Abstract: As a global disease, hepatitis B still threatens human health. However, the pathogenesis of hepatitis caused by HBV remains unclear. The innate immune system in the liver can detect HBV infection and use every strategy to eliminate the virus. DNA recognition receptors play an important role in this process; they recognize HBV DNA or pgRNA in cytoplasm or nucleus, activate innate immunity through various signaling pathways to produce inflammatory cytokines and interferon, and finally exert their antiviral effect. This article summarizes the DNA recognition receptors involved in inflammation induced by HBV and HBV clearance, elaborates on their detailed pathways, and discusses the issues regarding the role of DNA recognition receptors in liver innate immunity induced by HBV and related perspectives.
- hepatitis B /
- receptors, pattern recognition /
- review

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