鞘氨醇激酶信号通路在肝纤维化中的作用机制

孙跃; 兰天; 郭姣

doi:10.3969/j.issn.1001-5256.2017.09.038

鞘氨醇激酶信号通路在肝纤维化中的作用机制

DOI: 10.3969/j.issn.1001-5256.2017.09.038

1. 广东药科大学中医药研究院
2. 广东省代谢病中西医结合研究中心
3. 广东药科大学药学院药理系

基金项目:

广东省科技厅国际合作项目(2015A050502050)；广东省教育厅创新强校项目(2014GKPT021)；

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2017-04-17
- 出版日期: 2017-09-20

Research advances in the sphingosine kinase signaling pathway in liver fibrosis

Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine

Research funding:

摘要

摘要: 肝纤维化的形成主要体现为肝星状细胞的激活和细胞外基质合成降解的失衡。鞘氨醇激酶-1-磷酸鞘氨醇-1-磷酸鞘氨醇受体（SphK-S1P-S1PRs）信号通路在调控细胞的增殖、迁移以及炎症反应等生命活动中发挥重要作用。介绍了SphK、S1P、S1PRs的分布及生物学功能,简述了SphK-S1P-S1PRs信号通路在肝纤维化中的作用机制及其研究进展。多项研究证实SphK-S1P-S1PRs信号通路在肝纤维化疾病研究中起关键性作用,深入的探索有助于为临床上肝纤维化治理和药物新靶点开发提供新的思路。
- 肝硬化 /
- 鞘氨醇激酶 /
- 转化生长因子β1 /
- 信号传导 /
- 综述
Abstract: Formation of liver fibrosis mainly involves activation of hepatic stellate cell and imbalance between synthesis and degradation of extracellular matrix. The sphingosine kinase ( Sph K) /sphingosine 1-phosphate ( S1P) /sphingosine 1-phosphate receptors ( S1PRs) signaling pathway plays an important role in the regulation of cell life activities including proliferation, migration, and inflammatory response.This article introduces the distribution and biological functions of Sph K, S1P, and S1PRs and elaborates on the research advances in mechanism of action of the Sph K/S1P/and S1PRs signaling pathway in liver fibrosis. Many studies have confirmed the important role of the Sph K/S1P/and S1PRs signaling pathway in liver fibrosis, and in-depth exploration helps to provide new thoughts for clinical treatment of liver fibrosis and development of new drug targets.
- liver cirrhosis /
- sphingosine kinase /
- transforming growth factor beta1 /
- signal transduction /
- review

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