IL-17与肝脏疾病的相关性

杨浦娟; 黄祎; 刘华宝

doi:10.3969/j.issn.1001-5256.2017.09.041

IL-17与肝脏疾病的相关性

DOI: 10.3969/j.issn.1001-5256.2017.09.041

重庆市中医院

基金项目:

重庆市卫生和计生委中医药科技项目课题(ZY20150305)；

详细信息

中图分类号: R575
计量
- 文章访问数: 411
- HTML全文浏览量: 17
- PDF下载量: 175
- 被引次数: 0
出版历程
- 收稿日期: 2017-03-28
- 出版日期: 2017-09-20

Research advances in the association between interleukin-17 and liver diseases

Chongqing Hospital of Traditional Chinese Medicine

Research funding:

摘要

摘要: IL-17是辅助性T淋巴细胞17产生的一种促炎因子。IL-17可诱导多种趋化因子参与机体的免疫调节和炎症反应。IL-17通过激活肝脏内多种细胞产生炎性介质,分泌多种促炎因子调控肝脏的炎症。IL-17在多种肝脏疾病中的表达增高,如病毒性肝病、脂肪性肝病、自身免疫性肝病、肝寄生虫感染,并可促进肝硬化和肝癌的发生发展,与肝功能衰竭、肝移植排斥反应相关。综述了近年IL-17在肝脏疾病中的相关研究及进展。
- 白细胞介素17 /
- 肝疾病 /
- 细胞因子类 /
- 综述
Abstract: Interleukin-17 ( IL-17) is a proinflammatory factor produced by T helper 17 cells and can induce a variety of chemokines which participate in the body's immunoregulation and inflammatory response. IL-17 can activate various liver cells to produce inflammatory mediators and secrete proinflammatory factors and thus regulate liver inflammation. IL-17 is upregulated in many liver diseases, such as virus hepatitis, fatty liver disease, autoimmune liver diseases, and parasite infection in the liver, and it can promote the development and progression of liver cirrhosis and liver cancer and is associated with liver failure and rejection reaction in liver transplantation. This article reviews the research advances in the role of IL-17 in liver diseases.
- interleukin-17 /
- liver diseases /
- cytokine /
- review

HTML全文

参考文献(44)

[1]ROUVIER E, LUCIANI MF, MATTEI MG, et al.CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNAinstability sequences, and homologous to a herpesvirus saimiri gene[J].J Immunol, 1993, 150 (12) :5445-5456.

[2]BETTELLI E, KORN T, KUCHROO VK.Th17:the third member of the effector T cell trilogy[J].Curr Opin Immunol, 2007, 19 (6) :652-657.

[3]KORN T, BETTELLI E, OUKKA M, et al.IL-17 and Th17 cells[J].Annu Rev Immunol, 2009, 27 (1) :485-517.

[4]WRIGHT JF, GUO Y, QUAZI A, et al.Identification of an interleukin 17F/17A heterodimer in activated human CD4+T cells[J].J Biol Chem, 2007, 282 (18) :13447-13455.

[5]AMER AO, SWANSON MS.Autophagy is an immediate macrophage response to Legionella pneumophila[J].Cell Microbiol, 2005, 7 (6) :765-778.

[6]MACE PD, RIEDL SJ.Molecular cell death platforms and assemblies[J].Curr Opin Cell Biol, 2010, 22 (6) :828-836.

[7]AMER A, FRANCHI L, KANNEGANTI TD, et al, Regulation of legionella phagosome maturation and infection through flagellin and host Ipaf[J].J Biol Chem, 2006, 281 (46) :35217-35223.

[8]PEDRA JH, SUTTERWALA FS, SUKUMARAN B, et al.ASC/PY-CARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection[J].J Immunol, 2007, 179 (7) :4783-4791.

[9]GUO JY, GAO ZS, JIANG SS, et al.Study progress of IL-17 and NF-kappa B pathway in RA[J].J Changchun Univ Chin Med, 2015, 31 (1) :192-194. (in Chinese) 郭江燕, 高梓珊, 姜姝姝, 等.IL-17和NF-κB通路与类风湿性关节炎的相关性研究[J].长春中医药大学学报, 2015, 31 (1) :192-194.

[10]WU J, XIU WS, LIN N, et al.Expression and significance of interleukin-17 in juvenile rats with inflammatory bowel disease[J].Chin J Med Offic, 2016, 44 (2) :156-159. (in Chinese) 吴捷, 修文叔, 林楠, 等.白介素-17在幼年大鼠炎症性肠病中表达及意义[J].临床军医杂志, 2016, 44 (2) :156-159.

[11]YANG GQ, MU L.The correlation between the T helper cells and cytokines and HBV[J].Med Recapitulate, 2015, 21 (7) :1197-1199. (in Chinese) 杨国强, 牟兰.辅助性T细胞及其细胞因子与HBV的关系[J].医学综述, 2015, 21 (7) :1197-1199.

[12]TRUJILLO-OCHOA JL, CORRAL-JARA KF, ESCOBEDO-MELNDEZ G, et al.T-helper 17-related cytokines and Ig Eantibodies during hepatitis A virus infection in children[J].Mem Inst Oswaldo Cruz, 2015, 110 (2) :263-266.

[13]YE Y, XIE X, YU J, et al.Involvement of Th17 and Th1 effector responses in patients with Hepatitis B[J].J Clin Immunol, 2010, 30 (4) :546-555.

[14]YANG C, CUI F, CHEN LM, et al.Correlation between Th17 and n Treg cell frequencies and the stages of progression in chronic hepatitis B[J].Mol Med Rep, 2016, 13 (1) :853-859.

[15]ZHANG J, YING H, WEI L, et al.Effect of nucleoside analogues in the treatment of hepatitis B cirrhosis and its effect on Th17 cell[J].Eur Rev Med Pharmacol Sci, 2017, 21 (2) :416-420.

[16]CUI FF, GONG ZJ.Clinical significance of changes on serum levels of IL-17, IL-6 and vitamin D in patients with chronic hepatitis C, liver cirrhosis and hepatocellular carcinoma[J].Chin J Gastroenterol Hepatol, 2014, 23 (12) :1448-1450. (in Chinese) 崔芳芳, 龚作炯.慢性丙型肝炎、肝硬化、肝癌患者血清IL-17、IL-6和维生素D水平变化及其临床意义[J].胃肠病学和肝病学杂志, 2014, 23 (12) :1448-1450.

[17]MENG P, ZHAO S, NIU X, et al.Involvement of the interleukin-23/interleukin-17 axis in chronic hepatitis C virus infection and its treatment responses[J].Int J Mol Sci, 2016, 17 (7) :1070.

[18]JIMENEZ-SOUSA MA, ALMANSA R, de la FUENTE C, et al.Increased Th1, Th17 and pro-fibrotic responses in hepatitis C-infected patients are down-regulated after 12 weeks of treatment with pegylated interferon plus ribavirin[J].Eur Cytokine Netw, 2010, 21 (2) :84-91.

[19]LIU LL.Studing on the immune pathogenesis of murine cytomegalovirus infection[D].Wuhan:Huazhong Univ Sci Tech, 2014. (in Chinese) 刘玲玲.小鼠巨细胞病毒免疫致病机制的研究[D].武汉:华中科技大学, 2014.

[20]LIU L, FU R.Intrahepatic expression of IL-17 in infantile cytomegalovirus hepatitis and its significance[J].Pract Clin Med, 2012, 1 (4) :7-9. (in Chinese) 刘岚, 傅睿.婴儿巨细胞病毒性肝炎患儿组织中IL-17的表达及意义[J].实用临床医学, 2012, 1 (4) :7-9.

[21]LEMMERS A, MORENO C, GUSTOT T, et al.The interleukin-17 pathway is involved in human alcoholic liver disease[J].Hepatology, 2009, 49 (2) :646.

[22]HARLEY IT, STANKIEWICZ TE, GILES DA, et al.IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice[J].Hepatology, 2014, 59 (5) :1830-1839.

[23]GILES DA, MORENO-FERNANDEZ ME, DIVANOVIC S.IL-17 axis driven inflammation in non-alcoholic fatty liver disease progression[J].Curr Drug Targets, 2015, 16 (12) :1315-1323.

[24]DUAN SP.Nuclear transcription factor-κB (NF-κB) , IL-17expression and significance of autoimmune liver disease in liver tissue[D].Xinxiang:Xinxiang Med Univ, 2014. (in Chinese) 段树鹏.核转录因子-κB (NF-κB) 和IL-17在自身免疫性肝病肝组织中的表达及意义[D].新乡:新乡医学院, 2014.

[25]QIAN C, JIANG T, ZHANG W, et al.Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis[J].Cytokine, 2013, 64 (1) :172-180.

[26]MAERDAN M, TUERHONGJIANG T, MA HC.Expression of IL-17 mRNA in patients with alveolar echinococcosis and its clinical significance[J].Clin J Curr Adv Gen Surg, 2014, 7 (10) :771-774. (in Chinese) 马尔旦·马合木提, 吐尔洪江·吐逊, 马海长.IL-17 mRNA在肝脏泡型包虫病中的表达及其临床意义[J].中国现代普通外科进展, 2014, 7 (10) :771-774.

[27]ANTHONY B, MATHIESON W, de CASTRO-BORGES W, et al.Schistosoma mansoni:egg-induced downregulation of hepatic stellate cell activation and fibrogenesis[J].Exp Parasitol, 2010, 124 (4) :409-420.

[28]WANG X, SUN R, WEI H, et al.High-mobility group box1 (HMGB1) -Toll-like receptor (TLR) 4-interleukin (IL) -23-IL-17A axis in drug-induced damage-associated lethal hepatitis:Interaction ofγδT cells with macrophages[J].Hepatology, 2013, 57 (1) :373-384.

[29]LI HY.IL-17 inhibits apoptosis of hepatocytes and involves in liver injury and repairment[D].Xi'an:The Fourth Mil Med Univ, 2014. (in Chinese) 李海媛.IL-17调控肝细胞参与肝脏损伤与修复[D].西安:第四军医大学, 2014.

[30]YANG MX.Expression and significance of IL-17 and associated cytokines in rat model of anit induced cholestasis liver fibrosis[D].Nanning:Guangxi Med Univ, 2016. (in Chinese) 杨梅雄.IL-17及相关细胞因子在ANIT致胆汁淤积性肝纤维化大鼠模型中的表达及意义[D].南宁:广西医科大学, 2016.

[31]ZHAO X, SHENG HP, YANG Y, et al.Clinical significance of serum IL-17 cytokine in patients with chronic hepatitis B[J].J Xi'an Jiaotong Univ:Med Sci, 2017, 38 (1) :83-87. (in Chinese) 赵霞, 盛慧萍, 杨岩, 等.慢性乙型肝炎患者外周血IL-17细胞因子水平及其临床意义[J].西安交通大学学报:医学版, 2017, 38 (1) :83-87.

[32] YANG C, CUI F, CHEN LM, et al.Correlation between Th17 and n Treg cell frequencies and the stages of progression in chronic hepatitis B[J].Mol Med Rep, 2016, 13 (1) :853-859.

[33]WANG J, LIU Y, XIE L, et al.Association of IL-17A and IL-17F gene polymorphisms with chronic hepatitis B and hepatitis B virus-related liver cirrhosis in a Chinese population:A case-control study[J].Clin Res Hepatol Gastroenterol, 2016, 40 (3) :288-296.

[34]XUE ZM.Th17 pathway in the pathogenesis of alcholic liver disease and preliminary study on the mechanims of resveratrol[D].Shijiazhuang:Hebei Med Univ, 2013. (in Chinese) 薛芝敏.Th17通路在酒精性肝病发病机制中的作用及白藜芦醇对其治疗作用机制的初步研究[D].石家庄:河北医科大学, 2013.

[35]LAN RY, SALUNQA TL, TSUNEYAMA K, et al.Hepatic IL-17responses in human and murine primary biliary cirrhosis[J].J Autoimmun, 2009, 32 (1) :43-51.

[36]MACEK JILKOVA Z, AFZAL S, MARCHE H, et al.Progression of fibrosis in patients with chronic viral hepatitis is associated with IL-17+neutrophils[J].Liver Int, 2016, 36 (8) :1116-1124.

[37]GU FM, LI QL, GAO Q, et al.IL-17 induces AKT-dependent IL-6/AK2/STAT3 activation and tumor progression in hepatoeellular carcinoma[J].Mol Cancer, 2011, 10:150.

[38]ZHENG X.Expression and significance of IL-17 in primary liver cancer[D].Wuhan:Huazhong Univ Sci Tech, 2010. (in Chinese) 郑翔.原发性肝癌中IL-17的表达及意义的研究[D].武汉:华中科技大学, 2010.

[39]WU J.The expression and significance of IL-17 in liver transplantation immunity of Rat infected with echinococcus multilocularis[D].Urumqi:Xinjiang Med Univ, 2012. (in Chinese) 巫姜.IL-17在泡球蚴感染大鼠肝移植免疫中的表达及意义[D].乌鲁木齐:新疆医科大学, 2012.

[40]LOONG CC, HSIEH HG, LUI WY, et al.Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection[J].J Pathol, 2002, 197 (3) :322-332.

[41]MENG ZJ, ZHANG YH, WEI ZQ, et al.High serum resistin associates with intrahepatic inflammation and necrosis:an index of disease severity for patients with chronic HBV infection[J].BMC Gastroenterol, 2017, 17 (1) :6.

[42]BAO S, ZHENG J, LI N, et al.Role of interleukin-23 in monocyte-derived dendritic cells of HBV-related acute-on-chronic liver failure and its correlation with the severity of liver damage[J].Clin Res Hepatol Gastroenterol, 2017, 41 (2) :147-155.

[43] HU FX.The changes and clinical significance of Thl7、Treg and CTL in peripheral blood of the patients with HBV associated subacute-onchronic liver failure[D].Suzhou:Suzhou Univ, 2010. (in Chinese) 胡凤霞.乙肝相关慢加亚急性肝衰竭患者外周血Thl 7、Treg及CTL细胞的变化及临床意义的初步探讨[D].苏州:苏州大学, 2010.

[44]DU WJ, ZHEN JH, ZENG ZQ, et al.Expression of Interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection:IL-17 in HBV infection[J].Diagn Pathol, 2013, 28 (8) :40.

施引文献

资源附件(0)

访问统计