肝硬化门静脉高压性胃病的发病机制及抗酸剂的治疗应用

杨宗国; 张建良

doi:10.3969/j.issn.1001-5256.2017.11.037

肝硬化门静脉高压性胃病的发病机制及抗酸剂的治疗应用

DOI: 10.3969/j.issn.1001-5256.2017.11.037

上海市公共卫生临床中心

基金项目:

北京医卫健康公益基金会项目；

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 收稿日期: 2017-05-27
- 出版日期: 2017-11-20

Pathogenesis of portal hypertensive gastropathy in cirrhotic patients and the application of antacids in treatment

Shanghai Public Health Clinical Center

Research funding:

摘要

摘要: 肝硬化门静脉高压性胃病(PHG)的发病率高,并发上消化道出血的风险大。胃黏膜损伤是其主要的病理改变,抗酸剂在肝硬化PHG中的应用研究较少且存在争议。对PHG的影响因素、胃黏膜损伤机制及抗酸剂的应用进行了概括。认为治疗PHG过程中,在降低门静脉压力的同时使用质子泵抑制剂等抑酸药物可提高PHG的治愈率。但不同抑酸药物干预肝硬化PHG的疗效及安全性进行客观评价仍需通过前瞻性、大样本、随机对照试验进一步证实。
- 门静脉高压性胃病 /
- 肝硬化 /
- 抗酸剂 /
- 综述
Abstract: Portal hypertensive gastropathy (PHG) has a high incidence rate in cirrhotic patients, leading to a high risk of upper gastrointestinal bleeding.Gastric mucosal injury is the major pathological change of PHG.There are few studies focusing on the clinical application of antacids in the treatment of PHG in cirrhotic patients and there are still controversies over this issue.This article reviews the influencing factors for PHG, the mechanism of gastric mucosal injury, and the application of antacids.It is pointed out that during the treatment of PHG, besides the reduction in portal venous pressure, the application of antacids such as proton pump inhibitors can improve the cure rate of PHG.Prospective randomized control trials with a large sample size are needed to further demonstrate the clinical effect and safety of antacids in the treatment of PHG in cirrhotic patients.
- portal hypertensive gastropathy /
- liver cirrhosis /
- antacids /
- review

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参考文献(35)

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