肝组织学评估在非酒精性脂肪性肝病临床研究及实践中的作用

蒋丽娜; 赵景民

doi:10.3969/j.issn.1001-5256.2017.12.009

肝组织学评估在非酒精性脂肪性肝病临床研究及实践中的作用

DOI: 10.3969/j.issn.1001-5256.2017.12.009

解放军第三〇二医院病理诊断与研究中心

基金项目:

首都卫生发展科研专项项目(首发2014-2-5032)；国家自然科学基金青年项目(81500450);国家自然科学基金面上项目(81673654)；

详细信息

中图分类号: R575.5
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出版历程
- 出版日期: 2017-12-20

Role of histological evaluation of the liver in clinical practice and research on nonalcoholic fatty liver disease

Research funding:

摘要

摘要: 肝活组织检查是非酒精性脂肪性肝病(NAFLD),尤其是非酒精性脂肪性肝炎(NASH)诊断的"金标准",尽管肝穿刺检查存在有创性、取样和评价误差等局限性,但在NAFLD/NASH临床试验研究及新药临床试验中,肝组织学评价是研究队列患者入组、主要治疗终点和(或)次要治疗终点评价的主要评价指标,具有其他方法目前尚不可替代的作用。NAFLD/NASH的组织学评价系统主要包括Brunt系统、美国NASH临床研究网络评分系统、欧洲SAF/FLIP评分系统和儿童NAFLD组织学评分系统,在临床实践和研究中应选择适合的组织学评分系统。
- 非酒精性脂肪性肝病 /
- 活组织检查,针吸 /
- 评价研究
Abstract: Liver biopsy is currently the gold standard for the diagnosis of nonalcoholic fatty liver disease ( NAFLD) , especially nonalcoholic steatohepatitis ( NASH) . Although liver biopsy has the limitations such as invasiveness, sampling error, and evaluation error, in clinical trials of NAFLD/NASH and related new drugs, it is still used to evaluate the enrollment of patients into a cohort and primary and/or secondary endpoints and cannot be replaced by other methods. The histological evaluation systems of NAFLD/NASH mainly include Brunt system, NASH-CRN scoring system, European SAF/FLIP scoring algorithm, and pediatric NAFLD histological scoring system, and an appropriate histological scoring system should be selected in clinical practice and research.
- nonalcoholic fatty liver disease /
- biopsy /
- needle

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参考文献(29)

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