microRNA在慢性乙型肝炎肝纤维化中的诊断价值

李萍英; 杨永耿; 陆伦根; 朱智勇; 王亚平; 马颖才

doi:10.3969/j.issn.1001-5256.2017.12.036

microRNA在慢性乙型肝炎肝纤维化中的诊断价值

DOI: 10.3969/j.issn.1001-5256.2017.12.036

1. 青海大学
2. 青海省人民医院消化科
3. 上海交通大学附属第一人民医院消化科

基金项目:

中国肝炎防治基金会天晴肝病基金项目(TQGB20140260)；

详细信息

中图分类号: R512.62;R575.2
计量
- 文章访问数: 1925
- HTML全文浏览量: 20
- PDF下载量: 409
- 被引次数: 0
出版历程
- 收稿日期: 2017-06-21
- 出版日期: 2017-12-20

Value of microRNAs in diagnosis of chronic hepatitis B-related liver fibrosis

Qinghai University

Research funding:

摘要

摘要: 寻找能够准确识别慢性乙型肝炎（CHB）肝纤维化的血清标志物十分重要。归纳了在CHB肝纤维化过程中存在表达差异的microRNA（miRNA）,分析表明随着肝纤维化发展,血清miR-33a、miR-185、miR-222等表达量升高,而血清miR-122、miR-29、miR-27b等表达量下降。发现血清miR-185、miR-122等miRNA单独或联合其他指标在诊断CHB肝纤维化中已具有一定的临床应用价值。认为应进一步加大对存在差异表达的具有诊断CHB肝纤维化价值的血清miRNA的研究。
- 肝炎,乙型,慢性 /
- 微RNAs /
- 肝硬化 /
- 综述
Abstract: It is very important to find suitable serum markers which can accurately identify chronic hepatitis B ( CHB) -related liver fibrosis. This article summarizes the differentially expressed serum microRNAs ( miRNAs) in the process of CHB-related liver fibrosis. The analysis shows that with the development of liver fibrosis, there are increases in the serum levels of miR-33 a, miR-185, and miR-222 and reductions in the serum levels of miR-122, miR-29, and miR-27 b. It has been found that miRNAs such as miR-185 and miR-122 measured alone or in combination with other indices have a certain clinical value in the diagnosis of CHB-related liver fibrosis. It is pointed out that further research should be conducted for differentially expressed serum miRNAs which have a certain value in the diagnosis of CHB-related liver fibrosis.
- hepatitis B, chronic /
- microRNAs /
- liver cirrhosis /
- review

HTML全文

参考文献(32)

[1]POVERO D, BUSLETTA C, NOVO E, et al.Liver fibrosis:a dynamic and potentially reversible process[J].Histol Histopathol, 2010, 25 (8) :1075-1091.

[2]MANNING D, AFDHAL N.Diagnosis and quantitation of fibrosis[J].Gastroenterology, 2008, 134 (6) :1670-1681.

[3]STANDISH R, CHOLONGITAS E, DHILLON A, et al.An appraisal of the histopathological assessment of liver fibrosis[J].Gut, 2006, 55 (4) :569-578.

[4]LU LG, ZENG MD.Diagnosis and evaluation of hepatitis fibrosis[J].Chin J Hepatol, 2005, 13 (8) :603-604. (in Chinese) 陆伦根, 曾民德.肝纤维化的诊断和评估[J].中华肝脏病杂志, 2005, 13 (8) :603-604.

[5]LI Y, CHEN Y, ZHAO Y.The diagnostic value of the FIB-4 index for staging hepatitis B-related fibrosis:a meta-analysis[J].PLo S One, 2014, 9 (8) :e105728.

[6]KIM W, BERG T, ASSELAH T, et al.Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients[J].J Hepatol, 2016, 64 (4) :773-780.

[7]XIAO G, YANG J, YAN L.Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection:a systemic review and meta-analysis[J].Hepatology, 2015, 61 (1) :292-302.

[8]LEI JW, TAN BB, LI WB, et al.Value of transient elastography measured with Fibro Touch in the diagnosis of liver fibrosis in chronic hepatitis patients with hepatocellular carcinoma[J].Chin J Med Offic, 2017, 45 (9) :930-933. (in Chinese) 雷洁雯, 谭碧波, 李万斌, 等.Fibro Touch瞬时弹性成像诊断慢性乙型肝炎合并肝癌患者肝纤维化程度应用研究[J].临床军医杂志, 2017, 45 (9) :930-933.

[9]SONG Y, WANG F, HUANG Q, et al.MicroRNAs contribute to hepatocellular carcinoma[J].Mini Rev Med Chem, 2015, 15 (6) :459-66.

[10]LUO Y, HAN ZW, TIAN N, et al.Research progress on the relationship between miRNAs and common liver disease[J].J Zhejiang Univ Tradit Chin Med, 2014, 38 (1) :110-114. (in Chinese) 罗阳, 韩子午, 田男, 等.miRNA与常见肝病发生发展关系的研究进展[J].浙江中医药大学学报, 2014, 38 (1) :110-114.

[11]LI G, GONG Q.Research advances in signaling pathways involved in liver fibrosis[J].Guangdong Med J, 2014, 35 (3) :453-455. (in Chinese) 李刚, 龚权.肝纤维化信号传导通路研究进展[J].广东医学, 2014, 35 (3) :453-455.

[12]ARATAKI K, HAYES C, AKAMATSU S, et al.Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B[J].J Med Virol, 2013, 85 (5) :789-98.

[13]WEI Y, CUI G, YE P, et al.MicroRNAs may solve the mystery of chronic hepatitis B virus infection[J].World J Gastroenterol, 2013, 19 (30) :4867-4876.

[14]LAMONTAGNE J, STEEL L, BOUCHARD M.Hepatitis B virus and microRNAs:Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases[J].World JGastroenterol, 2015, 21 (24) :7375-7399.

[15]ZHANG QQ, LU LG.Research advances in the value of miRNA in diagnosis of chronic liver diseases and liver fibrosis[J].J Diagn Concepts Pract, 2015, 14 (4) :367-370. (in Chinese) 张清清, 陆伦根.miRNA诊断慢性肝病及肝纤维化价值的研究进展[J].诊断学理论与实践, 2015, 14 (4) :367-370.

[16]ZHANG W, JIA JD.Pathogenesis and new therapeutic targets of liver fibrosis[J].J Clin Hepatol, 2017, 33 (3) :409-412. (in Chinese) 张伟, 贾继东.肝纤维化的发病机制及治疗新靶点[J].临床肝胆病杂志, 2017, 33 (3) :409-412.

[17] XU MD, LI WQ, YU HY.Association of microRNA with liver diseases and liver fibrosis[J].Chin J Pathol, 2011, 40 (1) :65-67. (in Chinese) 许蜜蝶, 李维卿, 余宏宇.Micro RNA与肝病及肝纤维化相关研究[J].中华病理学杂志, 2011, 40 (1) :65-67.

[18]ZHENG J, ZHOU Z, XU Z, et al.Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression[J].Mol Med Rep, 2015, 12 (1) :1584-1590.

[19]APPOURCHAUX K, DOKMAK S, RESCHE R, et al.MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C[J].Sci Rep, 2016, 6:34935.

[20]LI B, LI D, CHEN C, et al.Potentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis[J].Sci Rep, 2016, 6:34157.

[21]HUANG C, SUN C, ZHAO F, et al.miR-33a levels in hepatic and serum after chronic HBV-induced fibrosis[J].J Gastroenterol, 2015, 50 (4) :480-490.

[22]CHEN Y, ZHU J, WU H, et al.Circulating microRNAs as a fingerprint for liver cirrhosis[J].PLo S one, 2013, 8 (6) :e66577.

[23]ZHANG Q, XU M, QU Y, et al.Analysis of the differential expression of circulating microRNAs during the progression of hepatic fibrosis in patients with chronic hepatitis B virus infection[J].Mol Med Rep, 2015, 12 (4) :5647-5654.

[24]CHEN R, WU J, LIU T, et al.MicroRNA profile analysis in the liver fibrotic tissues of chronic hepatitis B patients[J].J Dig Dis, 2017, 18 (2) :115-124.

[25]MA YH, HAN M, FENG SH, et al.Differential expression of plasma microRNA in patients with HBV-related liver fibrosis[J].Chin J Hepatol, 2017, 9 (1) :20-26.马艳华, 韩铭, 冯胜虎, 等.HBV相关肝纤维化患者血浆microRNA的差异表达[J].中华肝脏病杂志, 2017, 9 (1) :20-26.

[26]WAIDMANN O, BIHRER V, PLELI T, et al.Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection[J].J Viral Hepat, 2012, 19 (2) :e58-e65.

[27]LAMBRECHT J, JAN POORTMANS P, VERHULST S, et al.Circulating ECV-associated miRNAs as potential clinical biomarkers in early stage HBV and HCV induced liver fibrosis[J].Front Pharmacol, 2017, 8:56.

[28]RODERBURG C, URBAN G, BETTERMANN K, et al.MicroRNA profiling reveals a role for miR-29 in human and murine liver fibrosis[J].Hepatology, 2011, 53 (1) :209-218.

[29] XING T, JIANG D, HUANG J, et al.Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease[J].Genet Mol Res, 2014, 13 (3) :7912-7918.

[30]HUANG C, ZHENG J, CHENG Q, et al.Serum microRNA-29levels correlate with disease progression in patients with chronic hepatitis B virus infection[J].J Dig Dis, 2014, 15 (11) :614-621.

[31]JIN B, ZHANG Y, JIN W, et al.MicroRNA panels as disease biomarkers distinguishing hepatitis B virus infection caused hepatitis and liver cirrhosis[J].Sci Rep, 2015, 5:15026.

[32]NAKAMURA M, KANDA T, JIANG X, et al.Serum microRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein are useful tools for liquid biopsy of the patients with hepatitis B virus and advanced liver fibrosis[J].PLo S One, 2017, 12 (5) :e0177302.

施引文献

资源附件(0)

访问统计