雌激素受体基因多态性与肝细胞癌发生发展的关系

冉晓娟; 杨京

doi:10.3969/j.issn.1001-5256.2018.02.047

雌激素受体基因多态性与肝细胞癌发生发展的关系

DOI: 10.3969/j.issn.1001-5256.2018.02.047

冉晓娟,
杨京

贵州医科大学附属医院感染科

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2018-02-20

Association between estrogen receptor gene polymorphisms and the development and progression of hepatocellular carcinoma

Department of Infectious Diseases, The Affiliated Hospital of Guizhou Medical University

摘要

摘要:
肝细胞癌的发生发展与雌激素相关,而雌激素发挥生理效应需结合其受体,雌激素受体的功能又受到相关基因的调控,基因的表达和功能则被基因多态性所影响,且肿瘤的遗传易感性由不同基因、不同多态性的组合效应构成,故认为雌激素受体基因多态性会对肝细胞癌的发生、发展及预后产生影响。对近年来雌激素受体基因多态性的相关研究进展作一综述。
- 癌,肝细胞 /
- 受体,雌激素 /
- 多态性,单核苷酸 /
- 综述
Abstract:
The development and progression of hepatocellular carcinoma (HCC) is associated with estrogen, which exerts its physiological effect by binding to estrogen receptor (ER) .The function of ER is regulated by related genes, while the expression and function of these genes are affected by gene polymorphisms, and the genetic susceptibility to tumors is due to the combined effect of different genes and polymorphisms.Therefore, it is believed that ER gene polymorphisms may affect the development, progression, and prognosis of HCC.This article reviews the research advances in ER gene polymorphisms in recent years.
- carcinoma, hepatocellular /
- receptors, estrogen /
- polymorphism, single nucleotide /
- review

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参考文献(34)

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