酒精性肝纤维化的血清标志物研究进展

张艳芳; 黄晶

doi:10.3969/j.issn.1001-5256.2018.03.041

酒精性肝纤维化的血清标志物研究进展

DOI: 10.3969/j.issn.1001-5256.2018.03.041

张艳芳,
黄晶

吉林大学白求恩第一医院检验科

详细信息

中图分类号: R446.1;R575.2
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出版历程
- 出版日期: 2018-03-20

Research advances in serum markers for alcoholic liver fibrosis

摘要

摘要: 酒精性肝纤维化是由于长期过量摄入酒精使肝细胞发生炎症及坏死等改变,导致纤维结缔组织在肝内过度沉积而引发的一系列病理改变。实验室指标有助于助鉴别酒精性肝病,再进一步联合肝纤维化检验方法可诊断酒精性肝纤维化。其中肝纤维化诊断的"金标准"仍然是肝活组织检查,但因为其有创性,临床实践中开展受限。因此具有诊断价值的血清新型分子标志物近来不断被发现,且取得了较大突破;同时以综合多项临床生化指标、影像学为基础的肝纤维化非创伤性诊断预测模型对肝纤维化的诊疗也带来了新的希望。综述了近年来用血清标志物对酒精性肝纤维化非侵入诊断进行预测评估的研究进展。
- 肝硬化,酒精性 /
- 生物学标记 /
- 综述
Abstract: Alcoholic liver fibrosis is a series of pathological changes caused by excessive intrahepatic deposition of fibrous connective tissue due to hepatocyte inflammation and necrosis caused by excessive drinking. Laboratory markers help with the differentiation of alcoholic liver disease, and a combination of these markers and examination of liver fibrosis can be used for the diagnosis of alcoholic liver fibrosis. Liver biopsy remains the gold standard for the diagnosis of liver fibrosis, but its clinical application is limited by its invasiveness. Therefore, more and more new serum molecular markers with a diagnostic value have been identified in recent years, and great breakthroughs have been made. In addition, a noninvasive diagnostic and predictive model based on various biochemical parameters and imaging findings also brings new hope to the diagnosis and treatment of liver fibrosis. This article reviews the recent research advances in the noninvasive diagnosis of alcoholic liver fibrosis by serum markers.
- liver cirrhosis, alcoholic /
- biological markers /
- review

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