沉默调节蛋白1在非酒精性脂肪性肝病发生发展中的作用

杨帅; 何松青

doi:10.3969/j.issn.1001-5256.2018.03.047

沉默调节蛋白1在非酒精性脂肪性肝病发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2018.03.047

杨帅,
何松青

1. 桂林医学院
2. 桂林医学院附属医院

基金项目:

国家自然科学基金重点项目(81430014);国家自然科学基金面上项目(31370917)；

详细信息

中图分类号: R575.5
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出版历程
- 出版日期: 2018-03-20

Role of silent information regulator 1 in development and progression of nonalcoholic fatty liver disease

Guilin Medical University

Research funding:

摘要

摘要: 沉默调节蛋白1（SIRT1）为Sirtuin家族的一员,是依赖于烟酰腺嘌呤二核苷酸（NAD+）的去乙酰化酶,其主要作用是参与能量代谢﹑细胞生存、衰老及凋亡。而非酒精性脂肪性肝病（NAFLD）是一种与胰岛素抵抗、氧化应激及脂质过氧化等密切相关的慢性肝脏疾病。从SIRT1与NAFLD者的能量代谢关系﹑SIRT1与氧化应激、脂质过氧化、内质网应激等方面进行了阐述,认为SIRT1与NAFLD的发生发展密切相关。
- 非酒精性脂肪性肝病 /
- 沉默调节蛋白-1 /
- 胰岛素抵抗 /
- 内质网应激 /
- 综述
Abstract: Silent information regulator 1 ( SIRT1) , a member of the Sirtuin family, is a deacetylase depending on nicotinamide adenine dinucleotide and is mainly involved in energy metabolism, cell survival, aging, and apoptosis. Nonalcoholic fatty liver disease ( NAFLD) is a chronic liver disease closely related to insulin resistance, oxidative stress, and lipid peroxidation. This article elaborates on the association of SIRT1 with energy metabolism, oxidative stress, lipid peroxidation, and endoplasmic reticulum stress and points out that SIRT1 is closely associated with the development and progression of NAFLD.
- non-alcoholic fatty liver disease /
- silent information regulator transcription 1 /
- insulin resistance /
- endoplasmic reticulum stress /
- review

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参考文献(34)

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