肠道菌群-脂多糖-Toll样受体4轴与肝细胞癌的关系

黄蓉; 倪加加; 高毅

doi:10.3969/j.issn.1001-5256.2018.06.041

肠道菌群-脂多糖-Toll样受体4轴与肝细胞癌的关系

DOI: 10.3969/j.issn.1001-5256.2018.06.041

南方医科大学珠江医院肝胆二科

基金项目:

国家自然科学基金(81470875)；

详细信息

中图分类号: R735.7
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- 被引次数: 0
出版历程
- 收稿日期: 2017-12-11
- 出版日期: 2018-06-20

The association between the intestinal microbiota-lipopolysaccharide-Toll-like receptor 4 axis and hepatocellular carcinoma

Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University

Research funding:

摘要

摘要: 肝细胞癌是各种慢性肝病终末期的主要并发症,研究表明肝病患者普遍存在肠道屏障破坏和肠道菌群紊乱,导致肠道细菌移位,发生内毒素血症。Toll样受体4是肝内一种模式识别受体,能够结合内毒素中的活性成分——脂多糖,通过胞内一系列信号转导途径导致免疫炎症反应,最终促进肝纤维化和肿瘤发生。综述了肠道菌群-脂多糖-Toll样受体4轴与肝细胞癌发病机制相关研究进展。
- 癌,肝细胞 /
- 肠杆菌科 /
- 脂多糖类 /
- Toll样受体4 /
- 综述
Abstract: Hepatocellular carcinoma is the major complication of various end-stage chronic liver diseases. Studies have shown that intestinal barrier injury and intestinal flora disturbance are commonly seen in patients with liver diseases, which may cause intestinal bacterial translocation and endotoxemia. Toll-like receptor 4 (TLR4) is a pattern recognition receptor in the liver and can bind to lipopolysaccharide (LPS) , the active ingredient of endotoxin, result in immune inflammatory response via various signal transduction pathways, and finally promote hepatic fibrosis and tumorigenesis. This article reviews the intestinal microbiota-LPS-TLR4 axis and the pathogenesis of hepatocellular carcinoma.
- carcinoma, hepatocellular /
- enterobacteriaceae /
- lipopolysaccharides /
- Toll-like receptor 4 /
- review

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参考文献(41)

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