辅助性T淋巴细胞17和调节性T淋巴细胞及其平衡改变与非酒精性脂肪性肝病的关系

高伟华; 葛宽雪; 向晓星

doi:10.3969/j.issn.1001-5256.2018.06.046

辅助性T淋巴细胞17和调节性T淋巴细胞及其平衡改变与非酒精性脂肪性肝病的关系

DOI: 10.3969/j.issn.1001-5256.2018.06.046

1. 扬州大学医学院
2. 江苏省苏北人民医院

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中图分类号: R575.5
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出版历程
- 收稿日期: 2017-12-28
- 出版日期: 2018-06-20

Association of Th17 cells, regulatory T cells, and their imbalance with nonalcoholic fatty liver disease

Yangzhou University Medical College

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)与胰岛素抵抗、遗传易感性密切相关,是危害人类健康的慢性肝病之一。辅助性T淋巴细胞(Th17)、调节性T淋巴细胞(Treg)在一定条件下,两者存在相互转化的关系,维持免疫稳态。近年来,有关Th17与Treg及其平衡参与肝脏疾病的发生发展的研究也越来越深入。Th17与Treg及其平衡可能成为NAFLD治疗的新靶点,综述了Th17细胞、Treg细胞与NAFLD的关系及二者平衡改变在NAFLD疾病发生发展中最新的研究进展。
- 非酒精性脂肪性肝病 /
- T淋巴细胞,辅助诱导 /
- T淋巴细胞,调节性 /
- 综述
Abstract: Nonalcoholic fatty liver disease (NAFLD) is closely associated with insulin resistance and genetic susceptibility and is one of the chronic liver diseases that threaten human health. Under certain conditions, Th17 cells and regulatory T (Treg) cells can be transformed to each other to maintain immune homeostasis. In recent years, more and more studies have been performed on the involvement of Th17 and Treg cells in the development and progression of liver diseases. Th17 cells, Treg cells, and their balance may become the new targets for the treatment of NAFLD. This article reviews the latest research advances in the association of Th17 and Treg cells with NAFLD and the role of Th17/Treg balance in the development and progression of NAFLD.
- nonalcoholic fatty liver disease /
- T-lymphocytes, helper-inducer /
- T-lymphocytes, regulatory /
- review

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参考文献(49)

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