实验室常见检测指标对肝细胞癌预后预测价值的思考

文夏杰; 姚明解; 张玲; 鲁凤民

doi:10.3969/j.issn.1001-5256.2018.07.006

实验室常见检测指标对肝细胞癌预后预测价值的思考

DOI: 10.3969/j.issn.1001-5256.2018.07.006

1. 北京大学基础医学院病原生物学系暨感染病中心
2. 郑州大学附属肿瘤医院肝胆胰外科

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2018-03-30
- 出版日期: 2018-07-20

Value of common laboratory parameters in predicting the prognosis of hepatocellular carcinoma

Department of Microbiology and Infections Disease Center, School of Basic Medical Sciences, Peking University Health Science Center

摘要

摘要: 肝细胞癌（HCC）患者多有基础肝病,与其他癌症不同,HCC患者的肿瘤特征及残存肝功能均会影响到患者术后生存。为了帮助临床医生确定能够在根治性肝切除术中获益的患者,结合实验室前期研究及文献回顾,总结了对HCC患者预后有指导意义的常见临床检测指标。其中特别介绍了反映肝脏合成功能的血清学指标前白蛋白,其作为HCC患者术后独立预后因素被纳入传统Child-Pugh肝功能评价系统,形成改良的肝功能评分系统,可更加精确预测根治性肝切除术后患者的预后。这一评分系统或将有助于更加精准地选择适宜接受手术的HCC患者。
- 癌,肝细胞 /
- 预后 /
- 肿瘤标记,生物学
Abstract: Patients with hepatocellular carcinoma ( HCC) often have underlying liver diseases, and unlike other types of cancer, the features of HCC and residual liver function may affect patient survival after surgery. In order to help clinicians identify patients who can benefit from radical hepatectomy, this article summarizes common laboratory parameters which have guiding significance for the prognosis of HCC patients, with reference to preliminary laboratory studies and literature review. This article particularly introduces prealbumin, a serological marker which reflects liver synthetic function, and as an independent prognostic factor for HCC patients after surgery, prealbumin is integrated into the traditional Child-Pugh classification system to develop a modified liver function scoring system, which can accurately predict the prognosis of patients undergoing radical hepatectomy. This scoring system may help clinicians select HCC patients suitable for surgery.
- carcinoma, hepatocellular /
- prognosis /
- tumor markers, biological

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参考文献(22)

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