辅助性T淋巴细胞17和调节性T淋巴细胞及其平衡改变与自身免疫性肝炎的关系

葛宽雪; 高伟华; 向晓星

doi:10.3969/j.issn.1001-5256.2018.07.045

辅助性T淋巴细胞17和调节性T淋巴细胞及其平衡改变与自身免疫性肝炎的关系

DOI: 10.3969/j.issn.1001-5256.2018.07.045

扬州大学医学院附属苏北人民医院消化内科

详细信息

中图分类号: R575.1
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出版历程
- 收稿日期: 2018-01-08
- 出版日期: 2018-07-20

Association of regulatory T cells, T helper 17 cells, and change in their balance with autoimmune hepatitis

Department of Gastroenterology, Subei People's Hospital Affiliated to Yangzhou University Medical School

摘要

摘要: 自身免疫性肝炎是一种肝脏慢性炎症性疾病,其病因及发病机制尚未阐明。近年来,免疫调节异常机制成为研究热点之一。调节性T淋巴细胞（Treg）及辅助性T淋巴细胞（Th）17是CD4+T淋巴细胞的2个亚群,在功能、分化等方面有明显的差异,其平衡状态对于确保自身免疫系统的稳定发挥着重要作用,若两者出现失衡必然会造成免疫应答失常,导致自身免疫性疾病。深入研究Treg和Th17在自身免疫性肝炎中的发病机制,将为该病的免疫治疗提供新策略。就Treg和Th17在自身免疫性肝炎中的平衡变化作一综述。
- 肝炎,自身免疫性 /
- T淋巴细胞,调节性 /
- T淋巴细胞,辅助诱导 /
- 综述
Abstract: Autoimmune hepatitis ( AIH) is a chronic liver inflammatory disease, and its etiology and pathogenesis remain unclear. In recent years, abnormal immune regulation mechanism has become a research hotspot. Regulatory T ( Treg) cells and Th17 cells are two subsets of CD4+T cells and there are significant differences in function and differentiation between them. Treg/Th17 balance plays an important role in maintaining the stability of human immune system, and Treg/Th17 imbalance will cause abnormal immune response and then lead to autoimmune diseases. In-depth studies on the role of Treg and Th17 cells in the pathogenesis of AIH may provide new strategies for immunotherapy for this disease. This article reviews the change in Treg/Th17 balance in autoimmune hepatitis.
- hepatitis, autoimmune /
- T-lymphocytes, regulatory /
- T-lymphocytes, helper-inducer /
- review

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参考文献(38)

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