中医辨证联合奥拉帕尼治疗DNA修复缺陷的胆囊癌1例报告

张龙; 王洁; 赵远红

doi:10.3969/j.issn.1001-5256.2018.09.032

中医辨证联合奥拉帕尼治疗DNA修复缺陷的胆囊癌1例报告

DOI: 10.3969/j.issn.1001-5256.2018.09.032

1. 天津中医药大学研究生院
2. 天津中医药大学第一附属医院肿瘤科

详细信息

中图分类号: R735.8
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出版历程
- 出版日期: 2018-09-20

Traditional Chinese medicine treatment combined with olaparib for gallbladder cancer with DNA repair defects: A case report

Graduate School of Tianjin University of Traditional Chinese Medicine

摘要

摘要: <正>胆囊癌是最常见的胆道恶性肿瘤,患病率约占胆道恶性肿瘤的80%～95%[1],发病率女性高于男性,分布存在明显的地理和种族的差异,其发病机制尚不明确,可能与遗传和环境因素有关。有研究[2]指出大多数国家的胆囊癌患者5年生存率
- 胆囊肿瘤 /
- 奥拉帕尼 /
- 中草药 /
- 中医疗法 /
- 病例报告
- gallbladder neoplasms /
- olaparib /
- drugs, Chinese herbal /
- TCM therapy /
- case reports

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参考文献(8)

[1]HUNDAL R, SHAFFER EA.Gallbladder cancer:Epidemiology and outcome[J].Clin Epidemiol, 2014, 6 (1) :99-109.

[2]TORRE LA, SIEGEL RL, ISLAMI F, et al.Worldwide burden of and trends in mortality from gallbladder and other biliary tract cancers[J].Clin Gastroenterol Hepatol, 2018, 16 (3) :427-437.

[3]RAKIC'M, PATRLJ L, KOPLJAR M, et al.Current status and challenges in diagnosis and treatment of gallbladder cancer[J].Chin J Gen Surg, 2016, 25 (2) :157-161. (in Chineses) RAKIC'M, PATRLJ L, KOPLJAR M, 等.胆囊癌的临床诊疗现状与挑战[J].中国普通外科杂志, 2016, 25 (2) :157-161.

[4]ZHAO YH, JIA YJ, DONG CC, et al.Study on protective effect of Yigan Jiangzhi recipe on early alcoholic liver injury[J].Tianjin JTradit Chin Med, 2010, 27 (3) :265. (in Chineses) 赵远红, 贾英杰, 董承超, 等.益肝降脂方预处理对早期酒精性肝损伤的保护作用研究[J].天津中医药, 2010, 27 (3) :265.

[5]DEEKS ED.Olaparib:First global approval[J].Drugs, 2015, 75 (2) :231-240.

[6]FAN B, WU YM.PARP inhibitors-application of olapani in the treatment of ovarian cancer[J].Beijing Med J, 2016, 38 (11) :1206-1209. (in Chinese) 樊蓓, 吴玉梅.PARP抑制剂---奥拉帕尼应用于卵巢癌治疗的研究进展[J].北京医学, 2016, 38 (11) :1206-1209.

[7]TANG YN, JIN L, SUN CR.Olaparib:A new drug for hereditary ovarian cancer treatment[J].J Pharm Pract, 2015, 33 (4) :373-375. (in Chinese) 唐跃年, 金樑, 孙朝荣.治疗遗传性卵巢癌的新药-奥拉帕尼[J].药学实践杂志, 2015, 33 (4) :373-375.

[8]LIU Y, PENG YP, CHU X, et al.The role of ATM-mediated DNA repair in tumor radiotherapy[J].Chin J Gen Pract, 2016, 14 (3) :468-470. (in Chinese) 刘宇, 彭莹鹏, 楚溪, 等.ATM介导DNA修复在肿瘤放疗中的作用[J].中华全科医学, 2016, 14 (3) :468-470.

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