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MBOAT7 rs641738单核苷酸多态性与非酒精性脂肪性肝病的相关性

廖宋龄 刘守胜 王聪 陈立震 辛永宁 宣世英

引用本文:
Citation:

MBOAT7 rs641738单核苷酸多态性与非酒精性脂肪性肝病的相关性

DOI: 10.3969/j.issn.1001-5256.2018.10.021
基金项目: 

国家自然科学基金面上项目(31770837); 青岛市市南区科技发展资金项目(2016-3-016-YY); 

详细信息
  • 中图分类号: R575.5

Association between MBOAT7 rs641738 polymorphism and nonalcoholic fatty liver disease

Research funding: 

 

  • 摘要:

    目的探讨我国青岛地区汉族人群中MBOAT7 rs641738位点多态性与非酒精性脂肪性肝病(NAFLD)发生的相关性,为NAFLD及其并发症的防治提供理论依据。方法纳入2017年4月-12月青岛市市立医院收入院的NAFLD患者113例,健康对照者74例。收集受试者的血液标本,进行DNA的提取,应用PCR及飞行时间质谱方法(MALDI-TOF MS)检测MBOAT7基因rs641738位点的基因型。应用χ2检验分析基因型的分布是否符合Hardy-Weinberg平衡法则,以确定检验样本是否具有群体代表性。同时收集受试者的临床资料及实验室肝功能等生化检查结果。2组间性别、基因型及等位基因频率比较应用χ2检验进行分析。符合正态分布的计量资料2组间比较采用t检验,不符合正态分布的2组间比较采用Wilcoxon秩和检验。基因多态性与NAFLD发生的相对风险度以比值比(OR)及其95%可信区间(95%CI)表示,应用非条件logistic回归模型计算OR及95%CI。结果MBOAT7 rs641738位点CC、CT、TT基因型分布在NAFLD组与对照组间无明显差异(χ2=0. 157,P=0. 6...

     

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