孕期服用抗病毒药物阻断HBV母婴传播的研究进展

王慧娟; 段钟平; 张桓虎; 任锋

doi:10.3969/j.issn.1001-5256.2018.10.032

孕期服用抗病毒药物阻断HBV母婴传播的研究进展

DOI: 10.3969/j.issn.1001-5256.2018.10.032

1. 山西医科大学附属第二临床医院消化内科
2. 首都医科大学附属北京佑安医院人工肝中心
3. 山西省肿瘤医院山西省肿瘤研究所
4. 首都医科大学附属北京佑安医院北京市肝病研究所

基金项目:

国家自然科学基金项目(81770611,81270532)；北京市自然科学基金项目(7162085)；首都特色临床应用研究(Z121107001012167)；北京市卫生系统高层次卫生技术人才培养计划(2013-3-075)；首都医科大学附属北京佑安医院中青年人才孵育项目(20150104)；北京市属医学科研院所公益发展改革试点项目(京医研2016-2)；

详细信息

中图分类号: R714.251
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出版历程
- 收稿日期: 2018-04-13
- 出版日期: 2018-10-20

Research advances in the application of antiviral drugs during pregnancy for blocking mother-to-child transmission of hepatitis B virus

Department of Gastroenterology, The Second Affiliated Hospital of Shanxi Medical University

Research funding:

摘要

摘要: 母婴垂直传播是慢性乙型肝炎患者感染HBV的主要途径,HBV感染率随着母亲携带HBV病毒量的增加逐步升高。虽然目前新生儿主被动免疫预防已基本实施,但HBV母婴垂直传播率仍在10%左右。孕妇高病毒载量时应在孕期采取抗病毒治疗,降低病毒量,从而预防及阻断HBV母婴传播,减少慢性乙型肝炎的发病率。通过检索国内外文献详细描述了抗病毒药物在孕期使用的安全性及有效性,为日后指导孕期服药提供依据。
- 肝炎病毒,乙型 /
- 疾病传播,垂直 /
- 抗病毒药 /
- 综述
Abstract: Mother-to-child vertical transmission is an important route of transmission for hepatitis B virus ( HBV) infection in patients with chronic hepatitis B, and the rate of HBV infection increases with the increase in the mother's HBV viral load. Although active and passive immunoprophylaxis has been implemented for neonates at present, the rate of mother-to-child vertical transmission of HBV remains around 10%. Therefore, pregnant women with a high viral load should receive antiviral therapy to reduce the viral load, in order to prevent and block the mother-to-child transmission of HBV and reduce the incidence rate of chronic hepatitis B. By retrieving related literature in China and foreign countries, this article describes the safety and efficacy of antiviral agents during pregnancy and provides a reliable basis for guiding medication during pregnancy.
- hepatitis B virus /
- disease transmission, vertical /
- antiviral agents /
- review

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