非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素

陈艳珍; 陈成良; 洪宇; 王冠; 焦健

doi:10.3969/j.issn.1001-5256.2018.10.037

非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素

DOI: 10.3969/j.issn.1001-5256.2018.10.037

吉林大学中日联谊医院消化内科

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中图分类号: R575
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出版历程
- 收稿日期: 2018-03-25
- 出版日期: 2018-10-20

Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis

Department of Gastroenterology, China-Japan Union Hospital of Jilin University

摘要

摘要: 目前,非酒精性脂肪性肝病(NAFLD)已经成为全球慢性肝病的主要病因,是隐源性肝硬化的常见致病因素。临床上,NAFLD患者多见于肥胖群体,但非肥胖人群中NAFLD亦不罕见,尤其是亚洲人群。非肥胖型NAFLD与肥胖型NAFLD代谢谱相当,但最近多项研究显示与肥胖型NAFLD相比,非肥胖型肝纤维化、肝硬化有其独特的特点。回顾了近年来非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素,以期更好地了解该病的预防、诊断和治疗。
- 非酒精性脂肪性肝病 /
- 肝硬化 /
- 综述
Abstract: At present, non-alcoholic fatty liver disease ( NAFLD) has become the major cause of chronic liver disease in the world and is considered a common pathogenic factor of cryptogenic cirrhosis. In clinical practice, NAFLD is commonly seen in obese patients; however, it is not rare among non-obese individuals, especially in the Asian population. Non-obese NAFLD patients have similar metabolic profiles to obese NAFLD patients, but many studies have revealed that compared with obese NAFLD, non-obese liver fibrosis and liver cirrhosis have unique features. This article reviews the research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis in recent years, in order to gain a better understanding of the prevention, diagnosis, and treatment of this disease.
- non-alcoholic fatty liver /
- liver cirrhosis /
- review

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