The role of traditional Chinese medicine in regulating cytokines associated with liver fibrosis
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摘要: 中医药治疗具有调节肝纤维化因子的优势,是未来治疗肝纤维化药物的候选。归纳了近年来中医药调节肝纤维化相关细胞因子的研究现状,提示中医药通过调节肝纤维化细胞因子对于阻断、逆转肝纤维化具有一定意义。Abstract: Traditional Chinese medicine (TCM) therapy has the advantage of regulating cytokines associated with liver fibrosis and is a candidate for the treatment of liver fibrosis in the future. This article summarizes the research advances in the role of TCM in regulating cytokines associated with liver fibrosis and points out that TCM has certain significance in blocking and reversing liver fibrosis by regulating related cytokines.
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Key words:
- liver fibrosis /
- drugs, Chinese herbal /
- cytokines /
- review
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[1] LI JX, CHEN J, YAO SK. Consensus on diagnosis and treatment of liver fibrosis with integrated traditional Chinese and Western Medicine (2017) [J]. Chin J Integr Tradit West Med Dig, 2017, 25 (12) :895-900. (in Chinese) 李军祥, 陈誩, 姚树坤.肝纤维化中西医结合诊疗共识意见 (2017年) [J].中国中西医结合消化杂志, 2017, 25 (12) :895-900. [2] MUIR AJ. Understanding the complexities of cirrhosis[J]. Clin Ther, 2015, 37 (8) :1822-1836. [3] LI N, LIU YD, GUO MZ, et al. Effect of adiponectin on hepatic stellate cell contraction induced by endothelin-1 and its mechanism of action[J]. J Clin Hepatol, 2016, 32 (2) :307-311. (in Chinese) 李楠, 刘迎娣, 郭明洲, 等.外源性脂联素对内皮素1诱导的肝星状细胞收缩的影响及作用机制[J].临床肝胆病杂志, 2016, 32 (2) :307-311. [4] ZHU YP, BU SR. New progress in pathogenesis of liver fibrosis[J]. Chin Hepatol, 2016, 21 (5) :401-403. (in Chinese) 朱亚平, 卜淑蕊.肝纤维化发病机制研究新进展[J].肝脏, 2016, 21 (5) :401-403. [5] GUO R, YAN M. The research progress of cellular and molecular mechanism in liver fibrosis[J/CD]. Chin J Liver Dis:Electronic Edition, 2012, 4 (4) :57-62. (in Chinese) 郭蓉, 阎明.肝纤维化的细胞和分子机制研究进展[J/CD].中国肝脏病杂志:电子版, 2012, 4 (4) :57-62. [6] CAO Y, XIA YZ, CHEN J, et al. Anti-fibrosis effects of deoxyschizandrin in human hepatic stellate cells[J]. Chin J Clin Pharmacol Ther, 2016, 21 (8) :878-883. (in Chinese) 曹媛, 夏延哲, 陈杰, 等.五味子甲素在人肝星状细胞中的抗纤维化作用[J].中国临床药理学与治疗学, 2016, 21 (8) :878-883. [7] KAJDANIUK D, MAREK B, BORGIEL-MAREK H, et al. Transforming growth factorβ1 (TGFβ1) in physiology and pathology[J]. Endokrynol Pol, 2013, 64 (5) :384-396. [8] LANCE DP, STEVEN M, GULAM W. Activation of TGF-β1 promoter by hepatitis C virus-induced AP-1 and Sp1:Role of TGF-β1 in hepatic stellate cell activation and invasion[J]. PLo S One, 2013, 8 (2) :e56367. [9] LI FB, ZHAO H, PENG KR, et al. Expression of transforming growth factor-β1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue[J]. Genet Mol Res, 2016, 15 (1) :gmr. 15017217. [10] AN ZX, HE YL, WANG M, et al. Effects of Fupi Rougan formula on transforming growth factor-β1/Smads signal pathway in rats with liver fibrosis[J]. Tradit Chin Drug Res Clin Pharmacol, 2017, 28 (5) :557-563. (in Chinese) 安祯祥, 何远利, 王敏, 等.扶脾柔肝方对肝纤维化大鼠转化生长因子-β1/Smad信号通路的影响[J].中药新药与临床药理, 2017, 28 (5) :557-563. [11] YOU SP, ZHAO J, MUKARAM TDMT, et al. The effects of cistanche phenylethanoid glycosides on TGF-β1 expression of rats with hepatic fibrosis induced by BSA[J]. Carcinog Teratogenesis Mutagen, 2015, 27 (6) :409-414. (in Chinese) 由淑萍, 赵军, 木克热木·吐地买提, 等.肉苁蓉苯乙醇苷类成分对BSA诱导的肝纤维化大鼠转化生长因子β1表达的影响[J].癌变·畸变·突变, 2015, 27 (6) :409-414. [12] JING J, ZHAO JY, HUA B, et al. Inhibitory effect of flavonoids from Glycyrrhiza uralensis on expressions of TGF-β1 and Caspase-3 in thioacetamide-induced hepatic fibrosis in rats[J]. China J Chin Mater Med, 2015, 40 (15) :3034-3040. (in Chinese) 景晶, 赵金英, 华冰, 等.甘草总黄酮抑制硫代乙酰胺诱导肝纤维化大鼠肝组织中TGF-β-1及Caspase-3的表达[J].中国中药杂志, 2015, 40 (15) :3034-3040. [13] YANG ZQ, QIN XQ, CHEN Y, et al. Nine kinds of mice infected with hepatitis B virus after liver cirrhosis model[J]. J Changchun Univ Chin Med, 2017, 33 (2) :198-200. (in Chinese) 杨增强, 秦雪琴, 陈悦, 等.九味肝泰对小鼠感染乙型肝炎病毒后肝硬化模型的干预研究[J].长春中医药大学学报, 2017, 33 (2) :198-200. [14] FRANSIEN VD, PETER O, KLAAS P, et al. Targeted therapies in liver fibrosis:Combining the best parts of platelet-derived growth factor BB and interferon gamma[J]. Front Med (Lausanne) , 2015, 2:72. [15] KNOP J, APP C, HUFF T, et al. Identification of PDGF-BB binding to thymosinβ4 by chemical cross-linking[J]. Expert Opin Biol Ther, 2015, 15 (Suppl 1) :s147-s154. [16] WANG YH, ZHENG SQ, HUANG XL, et al. Effect of tissue inhibitor of metalloproteinase 1 on recruitment of hepatic macrophages in mice[J]. J Clin Exp Med, 2018, 17 (6) :561-564. (in Chinese) 王燕红, 郑书全, 黄小莉, 等.基质金属蛋白酶组织抑制因子-1对小鼠肝脏肝脏巨噬细胞募集作用的研究[J].临床和实验医学杂志, 2018, 17 (6) :561-564. [17] DONG J. Effects of emodin on the expressions of platelet derived growth factor-B and transforming growth factorβ1 in hepatic fibrosis rats[J/CD]. Chin J Digest Med Imageol:Electronic Edition, 2014, 4 (3) :124-126. (in Chinese) 董娟.大黄素对肝纤维化大鼠血小板衍生生长因子B、转化生长因子β-1表达的影响[J/CD].中华消化病与影像杂志:电子版, 2014, 4 (3) :124-126. [18] TU J, LING Y, SHOU QY, et al. Effect of rat serum containing biejiajianwan on proliferation and migration of rat hepatic stellate cells induced by PDGF[J]. J Zhejiang Univ Tradit Chin Med, 2015, 39 (2) :133-138. (in Chinese) 屠珏, 凌云, 寿旗扬, 等.鳖甲煎丸药物血清对PDGF诱导大鼠肝星状细胞增殖及迁移的影响[J].浙江中医药大学学报, 2015, 39 (2) :133-138. [19] ZHANG S, YUAN XP, WANG QL. Effects of phlorizin on TGF-β1and PDGF-BB expression in liver fibrosis mice hepatic tissue induced by schistosomiasis japonicum[J]. West China J Pharm Sci, 2015, 30 (1) :42-46. (in Chinese) 张硕, 袁希平, 王庆林.根皮苷对血吸虫病肝纤维化小鼠肝脏中TGF-β1和PDGF-BB表达的影响[J].华西药学杂志, 2015, 30 (1) :42-46 [20] CHOI SS, SYN WK, KARACA GF, et al. Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway[J]. J Biol Chem, 2010, 285 (47) :36551. [21] ZHANG W, NIU MH, YAN KF, et al. Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells[J]. Int J Biochem Cell Biol, 2013, 45 (3) :736-744. [22] HUANG C, MA TT, LI H, et al. Regulatory effects of litsea coreana level on the expressions of leptin and TGF-β1 to prevent the hepatic fibrosis in rats[J]. Chin Pharmacol Bull, 2012, 28 (12) :1666-1671. (in Chinese) 黄成, 马陶陶, 李浩, 等.豹皮樟总黄酮调控瘦素、TGF-β1对肝纤维化大鼠的预防作用研究[J].中国药理学通报, 2012, 28 (12) :1666-1671. [23] MENG X, WANG XC, FENG P, et al. The signal transduction pathway of rats with liver fibrosis regulated by leptin and interfering effects of mistletoe alkali[J]. Chin J Comp Med, 2015, 25 (10) :1-6. (in Chinese) 孟霞, 王学丛, 丰平, 等.瘦素对大鼠肝纤维化的信号转导调控及槲寄生碱的干预作用[J].中国比较医学杂志, 2015, 25 (10) :1-6. [24] LOU YY, LI DG, WANG YG, et al. The intervention effect and mechanism of Ganfujian formula on immune liver fibrosis in rats[J]. Chin J Gerontol, 2016, 36 (23) :5820-5822. (in Chinese) 娄莹莹, 李佃贵, 王彦刚, 等.肝复健方对大鼠免疫性肝纤维化的干预作用及机制[J].中国老年学杂志, 2016, 36 (23) :5820-5822. [25] GU LL, LI H. Kupffer cell function in liver fibrosis and fibrolysis:A doubleedged sword[J]. J Clin Hepatol, 2012, 28 (9) :714-716. (in Chinese) 谷莉莉, 李海. Kupffer细胞在肝纤维化发生过程中的双向调节作用[J].临床肝胆病杂志, 2012, 28 (9) :714-716. [26] ZHANG HT, ZHANG YQ. Effect of compound Biejia Ruangan tablet on the levels of TGF-β1, TNF-αand IL-6 in patients with hepatitis B fibrosis[J]. Shandong Med J, 2017, 57 (34) :36-38. (in Chinese) 张海涛, 张雨晴.复方鳖甲软肝片对乙肝肝纤维化患者疗效及血清TGF-β1、TNF-α、IL-6水平的影响[J].山东医药, 2017, 57 (34) :36-38. [27] ZHANG YB, LI CX, BO QY, et al. Effects of Buyang Huanwu decoction on liver fibrosis mice and its mechanism[J]. Chin J Gerontol, 2017, 37 (14) :3381-3384. (in Chinese) 张英博, 李春旭, 柏青杨, 等.补阳还五汤对肝纤维化小鼠肝功能、肝组织转化生长因子-β1、肿瘤坏死因子-α水平的作用及机制[J].中国老年学杂志, 2017, 37 (14) :3381-3384. [28] WU XY, XUN YH, LYU TF. The effect of Salvia miltiorrhiza ligustrazine on expression of TGFβ1, TNF-αin rat with hepatitis B[J]. Chin J Health Lab Technol, 2017, 27 (4) :498-501. (in Chinese) 吴晓瑛, 荀运浩, 吕铁锋.丹参川芎嗪对乙型肝炎大鼠转化生长因子-β1、肿瘤坏死因子-α表达影响[J].中国卫生检验杂志, 2017, 27 (4) :498-501. [29] SHEN GW, LI Q, LIU Y. Danji Huoxue decoction on serum inflammatory and liver fibrosis degradation indexes in hepatitis B patients with cirrhosis[J]. J Changchun Univ Chin Med, 2016, 32 (6) :1188-1190. (in Chinese) 申广文, 李强, 刘颖.丹鸡活血汤对乙型肝炎肝硬化患者血清炎症指标及肝纤维化降解指标的影响[J].长春中医药大学学报, 2016, 32 (6) :1188-1190. [30] GRASSINGER J, MUELLER G, ZAISS M, et al. Differentiation of hematopoietic progenitor cells towards the myeloid and B-lymphoid lineage by hepatocyte growth factor (HGF) and thrombopoietin (TPO) together with early acting cytokines[J]. Eur J Haematol, 2010, 77 (2) :134-144. [31] FORD H, ARTHUR LG. Hepatocyte growth factor treatment ameliorates diarrhea and bowel inflammation in a rat model of inflammatory bowel disease[J]. J Pediatr Surg, 2004, 39 (2) :139-143. [32] LI ZY, CUI LF, ZHANG LL, et al. Effect of Biejiajian Wan on hepatocyte growth factor expression in rats with immune hepatic fibrosis[J]. Chin J Exp Med Formul, 2012, 18 (15) :192-195. (in Chinese) 李志毅, 崔莉芳, 张伶俐, 等.鳖甲煎丸对免疫性肝纤维化大鼠肝组织HGF表达的影响[J].中国实验方剂学杂志, 2012, 18 (15) :192-195. [33] WANG Z, SHI HL, ZHAO QH. Effect of Qiang Gan Ruan Jian Pill on expression of HGF in liver tissue of rats with hepatic fibrosis[J]. Clin J Chin Med, 2014, 6 (35) :7-8. (in Chinese) 王正, 史海立, 赵庆华.强肝软坚丸对肝纤维化大鼠肝组织HGF表达的影响[J].中医临床研究, 2014, 6 (35) :7-8. [34] LI FH, LIU P, WANG CS, et al. Effects of CsB and its effective components on HGF-αand hepatocytes apoptosis at fibrotic liver in rats[J]. Chin J Exp Med Formul, 2013, 19 (14) :271-275. (in Chinese) 李风华, 刘平, 王春树, 等.虫草菌丝水煎液及其有效组分C12对肝纤维化大鼠HGF-α及肝细胞凋亡的影响[J].中国实验方剂学杂志, 2013, 19 (14) :271-275. [35] KURIYAMA N, DUARTE S, HAMADA T, et al. Tenascin-C:A novel mediator of hepatic ischemia and reperfusion injury[J]. Hepatology, 2011, 54 (6) :2125-2136. [36] LI ZY, LI CZ, WU YT, et al. The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas[J]. J Transl Med, 2014, 12 (1) :71. [37] RUKKUMANI R, PRIYANKA A, SANKAR P, et al. Ferulic acid influences hepatic expression pattern of matrix metalloproteinases during alcohol and PUFA induced toxicity[J]. Eur Rev Med Pharmacol Sci, 2012, 16 (15) :2147-2153. [38] BATUDE LG, XU YH, HAN ZQ, et al. Influences of Deduhonghua-7 powder on matrix metalloproteinases and transforming growth factor beta expression in liver fibrosis[J]. Chin J Clin Pharmacol, 2015, 31 (15) :1526-1529. (in Chinese) 巴图德力根, 徐艳华, 韩志强, 等.德都红花-7味散对基质金属蛋白酶及转化生长因子β1在肝纤维化中表达的影响[J].中国临床药理学杂志, 2015, 31 (15) :1526-1529. [39] SHANG LZ, WANG F, MIAO XL, et al. Effect and mechanism of supplemental Sini San on hepatic fibrosis in rats[J]. Chin J Exp Med Formul, 2013, 19 (5) :207-211. (in Chinese) 尚立芝, 王付, 苗小玲, 等.四逆散加味抗肝纤维化的作用及机制研究[J].中国实验方剂学杂志, 2013, 19 (5) :207-211. [40] JIANG H, XIA LZ, LI Y, et al. Effect of Panax notoginseng saponins on expressions of MMP-13 and TIMP-1 in rats with hepatic fibrosis[J]. China J Chin Mater Med, 2013, 38 (8) :1206-1210. (in Chinese) 姜辉, 夏伦祝, 李颖, 等.三七总皂苷对肝纤维化大鼠基质金属蛋白酶-13及其抑制因子-1表达的影响[J].中国中药杂志, 2013, 38 (8) :1206-1210. [41] LIU MH, JIA HT, XUE BY. Effect of compound Qizhu tablet on the expression of 4 cytokines in rats with liver fibrosis[J]. Chin J Exp Med Formul, 2012, 18 (21) :218-221. (in Chinese) 刘鸣昊, 贾涵婷, 薛博瑜.复方芪珠方对肝纤维化大鼠4种细胞因子表达的影响[J].中国实验方剂学杂志, 2012, 18 (21) :218-221. [42] ZHONG WC, ZHOU CY, GAO L, et al. Protective effects of Dahuang Zhechong pills on mice with alcohol-induced liver fibrosis[J]. Chin Tradit Patent Med, 2017, 39 (12) :2475-2480. (in Chinese) 钟伟超, 周楚莹, 高磊, 等.大黄蛰虫丸对小鼠酒精性肝纤维化损伤的保护作用[J].中成药, 2017, 39 (12) :2475-2480. [43] MO XH, LIANG T. Effect of puerarin on expression levels of TLR-4, NF-κB, and AP-1 in carbom tetrachloride induced liver fibrosis rats[J]. Chin Hosp Pharm J, 2017, 37 (14) :1348-1351. (in Chinese) 莫晓晖, 梁韬.葛根素对四氯化碳所诱导肝纤维化大鼠的干预作用及对TLR-4、NF-κB、AP-1的影响[J].中国医院药学杂志, 2017, 37 (14) :1348-1351.
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