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原发性肝癌组织中长链非编码RNA外泌体复合物7的表达及临床意义

方长英 朱传卫 张青松 何勇勇

方长英, 朱传卫, 张青松, 何勇勇. 原发性肝癌组织中长链非编码RNA外泌体复合物7的表达及临床意义[J]. 临床肝胆病杂志, 2019, 35(1): 123-126. DOI: 10.3969/j.issn.1001-5256.2019.01.023.
引用本文: 方长英, 朱传卫, 张青松, 何勇勇. 原发性肝癌组织中长链非编码RNA外泌体复合物7的表达及临床意义[J]. 临床肝胆病杂志, 2019, 35(1): 123-126. DOI: 10.3969/j.issn.1001-5256.2019.01.023.
Fang ZhangYing, Zhu ChuanWei, Zhang QingSong, He YongYong. Expression and clinical significance of long non-coding RNA exocyst complex component 7 in hepatocellular carcinoma[J]. J Clin Hepatol, 2019, 35(1): 123-126. DOI: 10.3969/j.issn.1001-5256.2019.01.023.
Citation: Fang ZhangYing, Zhu ChuanWei, Zhang QingSong, He YongYong. Expression and clinical significance of long non-coding RNA exocyst complex component 7 in hepatocellular carcinoma[J]. J Clin Hepatol, 2019, 35(1): 123-126. DOI: 10.3969/j.issn.1001-5256.2019.01.023.

原发性肝癌组织中长链非编码RNA外泌体复合物7的表达及临床意义

DOI: 10.3969/j.issn.1001-5256.2019.01.023
详细信息
  • 中图分类号: R735.7;R730.43

Expression and clinical significance of long non-coding RNA exocyst complex component 7 in hepatocellular carcinoma

  • 摘要:

    目的探讨长链非编码RNA外泌体复合物7(LncRNA EXOC7)在原发性肝癌组织中的表达及临床意义。方法收集于宣城市中心医院2010年1月-2014年1月行肝癌手术患者的肝癌组织及其癌旁组织标本79对,采用real-time PCR分别检测肝癌组织和癌旁组织中LncRNA EXOC7的表达情况,分析其与病理特征和预后的关系。计量资料2组间比较采用t检验,计数资料2组间比较采用χ2检验或Fisher确切概率法,术后患者的生存分析采用Kaplan-Meier方法,使用Cox模型分析影响预后的危险因素。结果 LncRNA EXOC7在肝癌组织中表达水平明显高于癌旁组织(6. 211±0. 637 vs 2. 924±0. 415,t=4. 106,P <0. 01)。肿瘤大小(χ2=5. 157,P=0. 023)、有无门静脉癌栓(χ2=4. 049,P=0. 044)、有无脏器转移(χ2=4. 345,P=0. 037)和TNM分期(χ2=6. 479,P=0. 011)在LncRNA EXOC7高表达和低表达组间差异均有统计学意义。LncRNA EXOC7高表达组的无瘤生存期(χ...

     

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