肠道菌群在自身免疫性肝病发生发展及治疗中的作用

黄春洋; 陈杰; 刘燕敏; 单晶

doi:10.3969/j.issn.1001-5256.2019.01.045

肠道菌群在自身免疫性肝病发生发展及治疗中的作用

DOI: 10.3969/j.issn.1001-5256.2019.01.045

首都医科大学附属北京佑安医院肝病免疫科

基金项目:

丰台区卫生系统科研项目(2017-62)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2019-01-20

Role of intestinal flora in the development/progression and treatment of autoimmune liver diseases

Department of Hepatology and Immunology, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China

Research funding:

摘要

摘要:
肠道细菌过度生长、肠道菌群变化、细菌及其产物的易位与胆汁酸代谢的相互作用等是多种肝病发生发展的重要共同途径。肝细胞通过门静脉系统持续的暴露于肠道代谢产物及各种抗原抗体之下,某些肠道细菌成分或代谢物可通过"分子模拟"等多个机制启动针对肝细胞的自身免疫机制。因此肠道菌群在自身免疫性肝病,包括自身免疫性肝炎、原发性胆汁性胆管炎和原发性硬化性胆管炎的发生发展及治疗过程中发挥了重要作用,对近年来的相关研究进展进行了阐述和总结。
- 肝炎,自身免疫性 /
- 肝硬化,胆汁性 /
- 胆管炎,硬化性 /
- 肠杆菌科 /
- 综述
Abstract:
Overgrowth of intestinal bacteria, change in intestinal flora, translocation between bacteria and their products, and bile acid metabolism are the important pathways for the development and progression of liver diseases.Hepatocytes are persistently exposed to intestinal metabolites and various antigens and antibodies via the portal vein system, and the constituents or metabolites of some intestinal bacteria can activate the autoimmune mechanism targeting hepatocytes through several mechanisms, including molecular mimicry.Therefore, intestinal flora plays an important role in the development/progression and treatment of autoimmune liver diseases, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis.This article reviews the related research advances in recent years.
- hepatitis, autoimmune /
- liver cirrhosis, biliary /
- cholangitis, sclerosing /
- enterobacteriaceae /
- review

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参考文献(32)

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