胆汁酸的肝肠循环及肠道微生态在胆汁淤积性肝病发病和治疗中的作用

贾昊宇; 杨长青

doi:10.3969/j.issn.1001-5256.2019.02.007

胆汁酸的肝肠循环及肠道微生态在胆汁淤积性肝病发病和治疗中的作用

DOI: 10.3969/j.issn.1001-5256.2019.02.007

同济大学附属同济医院消化科

基金项目:

国家自然科学基金项目(81670571,81820108006)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2019-02-20

The role of enterohepatic circulation of bile acids and intestinal microbiota in the pathogenesis and treatment of cholestatic liver disease

Department of Gastroenterology, Tongji Hospital, Tongji University

Research funding:

摘要

摘要:
胆汁淤积性肝病是指由病毒、细菌、寄生虫、药物、毒物、自身免疫、酒精、结石、肿瘤和遗传代谢等一系列原因导致胆汁淤积发生而引起的肝脏疾病,主要表现为胆汁流量的改变和胆汁酸毒性的过度积累。在胆汁淤积性肝病的发病过程中,不仅有内源性胆汁酸的肝肠循环作用的参与,且肠道微生物群也通过调节代谢和免疫反应发挥重要作用。除此之外,肠道微生物群与胆汁酸的肝肠循环之间也存在密切的相互作用。胆汁酸可以改变肠道微生物群的组成,反之,肠道微生物也能够影响胆汁酸池。近年来针对胆汁酸的肝肠循环、肠道微生物群与胆汁淤积性肝病之间关系的研究日渐深入,为胆汁淤积性肝病的发病机制及治疗方法提供了一些新的研究方向。
- 胆汁淤积 /
- 胆酸类 /
- 肝肠循环 /
- 肠道微生物群
Abstract:
Cholestatic liver disease refers to a liver disorder caused by cholestasis, which arise from a series of etiologies such as viruses, bacteria, parasites, drugs, poisons, autoimmunity, alcohol, stones, tumors, genetics, and metabolism. This disease has the main manifestations of a change in bile flow and excessive accumulation of bile acid toxicity. In the pathogenesis of cholestatic liver disease, not only does the enterohepatic circulation of endogenous bile acids work, but also the intestinal microbiota plays an important role by regulating metabolism and causing immune responses. In addition, more attention has been paid to the close interaction between intestinal microbiota and the enterohepatic circulation of bile acids. Bile acids can alter the composition of intestinal microbiota, which in turn affects the bile acid pool.In recent years, there has been increasing research on the relationship of the enterohepatic circulation of bile acids and intestinal microbiota with cholestatic liver disease, which may provide new research directions for the pathogenesis and treatment of cholestatic liver disease.
- cholestasis /
- cholic acids /
- enterohepatic circulation /
- intestinal microbiota

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参考文献(35)

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