Epidemiology of polypoid lesions of the gallbladder and related risk factors
-
摘要:
胆囊息肉样病变(PLG)临床常见,以非肿瘤性息肉为主,少部分为肿瘤性息肉。总结了PLG的流行病学及相关危险因素,提示PLG的发病是由性别、HBV感染、代谢综合征、内脏肥胖、低密度脂蛋白低水平、胆囊壁增厚、糖尿病等多种因素共同作用所致。随着PLG的发病率日趋升高,认为今后的研究重点应着眼于运用流行病学研究结果,对高危人群定期进行健康筛查,并对确诊患者进行规范化随访观察,发现并及早干预具有癌变可能的PLG。
Abstract:Polypoid lesions of the gallbladder ( PLG) is a common gallbladder disease in clinical practice. Most patients have non-adenomatous polyps, while adenomatous polyps are observed in a small number of patients. This article summarizes the epidemiology of PLG and related risk factors and points out that PLG is caused by the combined effect of various factors including sex, hepatitis B virus infection, metabolic syndrome, visceral obesity, a low level of low-density lipoprotein, gallbladder wall thickening, and diabetes. With the gradual increase in the incidence rate of PLG, epidemiological data should be used for health screening among the high-risk population, and standardized follow-up should be performed for patients with a confirmed diagnosis. PLG which may progress to cancer should be identified and intervention should be given as early as possible.
-
Key words:
- gallbladder diseases /
- polyps /
- epidemiology /
- risk factors /
- review
-
[1]CHOI YS, DO JH, SEO SW, et al.Prevalence and risk factors of gallbladder polypoid lesions in a healthy population[J].Yonsei Med J, 2016, 57 (6) :1370-1375. [2]LEE YJ, PARK KS, CHO KB, et al.Shifting prevalence of gallbladder polyps in Korea[J].J Korean Med Sci, 2014, 29 (9) :1247-1252. [3]MAO YS, MAI YF, LI FJ, et al.Prevalence and risk factors.of gallbladder polypoid lesions in Chinese petrochemical employees[J].World J Gastroenterol, 2013, 19 (27) :4393-4399. [4]ALDOURI AQ, MALIK HZ, WAYTT J, et al.The risk of gallblad-der cancer from polyps in a large multiethnic series[J].Eur J Surg Oncol, 2009, 35 (1) :48-51. [5]HWANG BW, KIM YL, KIM KH, et al.Prevalence and risk factors of gallbladder polyp, and association between gallbladder polyp and metabolic syndrome in health examinees[J].Korean J Fam Pract, 2017, 7 (1) :131-136. [6]ZHOU XF.Analysis of the incidence of polypoid lesion of gallbladder (PLG) in 1124 healthy persons by hemodial-ysis ultrasonography[J].J Shenyang Univ Med Sci, 2008, 10 (6) :90-91. (in Chinese) 周秀芳.超声检查1124例健康人胆囊息肉发病率及分析[J].沈阳医学院学报, 2008, 10 (6) :90-91. [7]XU Q, TAO LY, WU Q, et al.Prevalences of and risk factors for biliary stones and gallbladder polyps in a large Chinese population[J].HPB (Oxford) , 2012, 14 (6) :373-381. [8]YE XD.Investigation on risk factors of gallbladder polyp in community residents of zhongshan city[J].Med Innovation of China, 2018, 15 (12) :126-128. (in Chinese) 叶向东.中山市社区居民胆囊息肉的危险因素调查[J].中国医学创新, 2018, 15 (12) :126-128. [9]YANG HL, KONG L, HOU LL, et al.Analysis of risk factors for polypoid lesions of gallbladder among health examinees[J].World J Gastroenterol, 2012, 18 (23) :3015-3019. [10] CHEN AG, LI XJ, LIU N, et al.Clinical epidemiological characteristics and correlative factors of polypoid lesions of gallbladder[J].J Hunan Univ Chin Med, 2016, 36 (6) :223-224. (in Chinese) 陈爱国, 李小静, 刘宁, 等.胆囊息肉样病变的临床流行病学特点及其易感性因素分析[J].湖南中医药大学学报, 2016, 36 (6) :223-224. [11]ITO H, HANN LE, D'ANGELICA M, et al.Polypoid lesions of the gallbladder:Diagnosis and followup[J].J Am Coll Surg, 2009, 208 (4) :570-575. [12]KYU LJ, JAE HS, KANG HW, et al.Visceral obesity is associated with gallbladder polyps[J].Gut Liver, 2016, 10 (1) :133-139. [13]PARK EJ, LEE HS, LEE SH, et al.Association between metabolic syndrome and gallbladder polyps in healthy Korean adults[J].J Korean Med Sci, 2013, 28 (6) :876-80. [14]CHEN CH, SUN CA, CHOU YC, et al.A study on the correlation between gallbladder polyps and metabolic syndrome combined with fatty liver disease:An analysis of physical examination data[J].Int J Med Health Research, 2017, 3 (5) :20-25. [15]ZHANG BZ.A review on related risk factors of gallbladder polyp[J].J Qinghai Med, 2017, 47 (2) :78-80. (in Chinese) 张保柱.胆囊息肉相关危险因素研究进展[J].青海医药杂志, 2017, 47 (2) :78-80. [16]OKAMOTO M, YAMAGATA Z, TAKEDA Y, et al.The relationship between gall-bladder disease and smoking and drinking habits in middle-aged Japanese[J].Gastroenterol, 2002, 37 (6) :455-462. [17]ZHAO YY, XIE TH, ZHANG SJ, et al.Polypoid lesions of the gallbladder:natural history and its influence factors[J].J Shihezi Univ:Natural Science, 2013, 31 (1) :65-68. (in Chinese) 赵阳阳, 谢天皓, 张示杰, 等.胆囊息肉样病变自然病程及自然病程变化影响因素分析[J].石河子大学学报:自然科学版, 2013, 31 (1) :65-68. [18]YANG CG, YANG JZ, SONG G, et al.Epidemiological investigation of risk factors for gallbladder polypoid changes in flight personnel[J].Chin J Aviation Med, 2016, 27 (2) :107-111. (in Chinese) 杨崇格, 杨竞择, 宋光, 等.飞行人员胆囊息肉样变危险因素流行病学调查[J].中华航空航天医学杂志, 2016, 27 (2) :107-111. [19]TAKAHASHI Y, YAMAMICHI N, SHIMAMOTO T, et al.Helicobacter pylori infection is positively associated with gallstones:A large-scale cross-sectional study in Japan[J].J Gastroenterol, 2014, 49 (5) :882-889. [20]OH JS, LEE HM, LIN TC, et al.Relationship between gallbladder polyps and metabolic syndrome components in Korean male adults[J].Korean J Fam Pract, 2018, 8 (1) :21-24. [21]LU H, LIU QD.An excerpt of Joint guidelines between the European Society of Gastrointestinal and Abdominal Radiology (ESGAR) , European Association for Endoscopic Surgery and other Interventional Techniques (EAES) , International Society of Digestive Surgery-European Federation (EFISDS) and European Society of Gastrointestinal Endoscopy (ESGE) :Management and follow up of gallbladder polyps (2017) [J].JClin Hepatol, 2017, 33 (6) :1051-1055. (in Chinese) 卢昊, 刘全达.《2017年欧洲多学会联合指南:胆囊息肉管理和随访》摘译[J].临床肝胆病杂志, 2017, 33 (6) :1051-1055.
计量
- 文章访问数: 1723
- HTML全文浏览量: 38
- PDF下载量: 305
- 被引次数: 0