肝纤维化和肝硬化逆转的时代:现状与挑战

王冰琼; 孙亚朦; 尤红

doi:10.3969/j.issn.1001-5256.2019.04.001

肝纤维化和肝硬化逆转的时代:现状与挑战

DOI: 10.3969/j.issn.1001-5256.2019.04.001

首都医科大学附属北京友谊医院肝病中心国家消化系统疾病临床医学研究中心

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2019-01-12
- 出版日期: 2019-04-20

The era of the reversal of liver fibrosis and cirrhosis: Current status and challenges

Liver Research Center, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases

摘要

摘要: 越来越多的临床研究表明,有效的病因治疗可以逆转肝纤维化/早期肝硬化。纤维化逆转的准确评估对于治疗决策及判断预后具有重要价值。然而目前肝纤维化及肝硬化逆转的组织学"金标准"仍待完善,肝纤维化逆转的无创评估仍有争议,能否改善临床硬终点尚需长期队列观察,同时抗纤维化新药的临床疗效尚有待进一步证实。
- 肝硬化 /
- 生物学标记 /
- 活组织检查 /
- 述评
Abstract: An increasing number of clinical studies have shown that effective etiological therapy might achieve the reversal of liver fibrosis/early cirrhosis. An accurate assessment of fibrosis reversal is of great importance for treatment decision-making and prognosis prediction. At present, the“gold standard”for the histological evaluation of liver fibrosis/cirrhosis reversal remains to be perfected, and there is still a controversy over the noninvasive assessment of fibrosis reversal. Long-term cohort studies are needed to observe whether it can improve clinical hard endpoint, and the clinical effect of new anti-fibrotic drugs needs to be further confirmed.
- liver cirrhosis /
- biological markers /
- biopsy /
- editorial

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参考文献(37)

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