囊型包虫病药物新剂型研发及新药开发现状

尹杰; 樊海宁; 温浩; 王海久; 张灵强; 庞明泉; 顾贤波; 王涛; 潘思宇

doi:10.3969/j.issn.1001-5256.2019.04.045

囊型包虫病药物新剂型研发及新药开发现状

DOI: 10.3969/j.issn.1001-5256.2019.04.045

1. 青海大学研究生院
2. 青海大学附属医院肝胆胰外科
3. 青海省包虫病研究重点实验室
4. 新疆医科大学第一附属医院

基金项目:

2017国家重点研发计划“精准医学研究”专项(2017YFC0909900)；青海省包虫病临床医学研究中心项目(2017-SF-L2)； 2016青海省卫生计生委重点课题(2016-wjtg-04)；

详细信息

中图分类号: R532.32
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出版历程
- 出版日期: 2019-04-20

Current status of the research and development of new formulations and drugs for cystic echinococcosis

Graduate School of Qinghai University

Research funding:

摘要

摘要: 囊型包虫病(CE)由细粒棘球蚴感染引起,可累及全身器官。手术是治疗CE的主要方法。随着技术发展、精准手术及无瘤手术标准的引用,CE的手术禁区越来越小,但仍有许多患者因为无法手术而只能选择药物保守治疗。然而,目前治疗CE的药物选择很少,仅有苯并咪唑一类有较确切的疗效。现回顾目前国内外CE的药物治疗研究进展,为药物开发研究及临床药物应用选择提供参考。
- 棘球蚴病,肝 /
- 药用制剂 /
- 综述
Abstract: Cystic echinococcosis ( CE) is a zoonotic parasitic disease caused by Echinococcus granulosus infection and can involve the organs in the whole body. Surgery is the primary method for the treatment of CE. With the development of related techniques, precision operation, and no-tumor operation standards, more and more patients are able to receive surgical treatment, but there are still many patients who can only receive drug conservative treatment. However, there are limited drugs for the treatment of CE at present, and only benzimidazole has a definite therapeutic effect. This article reviews the research advances in the pharmacotherapy for CE in China and foreign countries, so as to provide a reference for drug research and development and clinical drug use.
- echinococcosis, hepatic /
- pharmaceutical preparations /
- review

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参考文献(43)

[1]NUNNARI G. Hepatic echinococcosis:Clinical and therapeutic aspects[J]. World J Gastroenterol, 2012, 18 (13) :1448.

[2]D'ALESSANDRO A. Polycystic echinococcosis in tropical America:Echinococcus vogeli and E. oligarthrus[J]. Acta Tropica, 1997, 67 (1) :43-65.

[3]NAKAO M, LAVIKAINEN A, YANAGIDA T, et al. Phylogenetic systematics of the genus Echinococcus (Cestoda:Taeniidae) [J]. Int J Parasitol, 2013, 43 (12) :1017-1029.

[4] Chinese College of Surgeons (CCS) Chinese Committe. Expert consensus on the diagnosis and treatment of hepatic cystic and alveolar echinococcosis (2015 edition) [J]. Chin J Dig Surg, 2015, 14 (4) :253-264. (in Chinese) 中国医师协会外科医师分会包虫病外科专业委员会.肝两型包虫病诊断与治疗专家共识 (2015版) [J].中华消化外科杂志, 2015, 14 (4) :253-264.

[5]LIU LX, YANG JY, FENG PC, et al. Clinical efficacy of threedimensional laparoscopic surgery in treatment of hepatic cystic echinococ cosis[J]. Chin J Dig Surg, 2018, 17 (1) :84-88. (in Chinese) 刘林勋, 杨金煜, 冯鹏才, 等. 3D腹腔镜手术治疗肝囊型包虫病的临床疗效[J].中华消化外科杂志, 2018, 17 (1) :84-88.

[6]MCMANUS DP, ZHANG W, LI J, et al. Echinococcosis[J].Lancet, 2003, 362 (9392) :1295-1304.

[7]NASERI M, AKBARZADEH A, SPOTIN A, et al. Scolicidal and apoptotic activities of albendazole sulfoxide and albendazole sulfoxide-loaded PLGA-PEG as a novel nanopolymeric particle against Echinococcus granulosus protoscoleces[J]. Parasitol Res, 2016, 115 (12) :4595-4603.

[8]HORTON RJ. Albendazole in treatment of human cystic echinococcosis:12 years of experience[J]. Acta Tropica, 1997, 64 (1-2) :79-93.

[9]ZHAO J, GAO HJ, WANG JH. Chinese invention patent about anti-parasitic drug albendazale[J]. Chin J Parasitol Parasit Dis, 2012, 30 (2) :152-156. (in Chinese) 赵军, 高惠静, 王建华.与抗寄生虫药物阿苯达唑相关的中国发明专利[J].中国寄生虫学与寄生虫病杂志, 2012, 30 (2) :152-156.

[10]CHAI JJ, MENGHEBA T, JIAO W, et al. Efficacy of ablendazole emulsion in treatment of 212 patients with cystic echinococcosis[J]. Chin J Parasitol Parasit Dis, 2011, 19 (3) :129-134. (in Chinese) 柴君杰, 孟贺巴特, 焦伟, 等.阿苯达唑乳剂治疗肝囊型包虫病212例临床疗效观察[J].中国寄生虫学与寄生虫病杂志, 2011, 19 (3) :129-134.

[11]CHAI J, MENGHEBAT, WEI J, et al. Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis[J]. Parasitol Int, 2004, 53 (1) :3-10.

[12]LI HT. Clinical study of liposomal albendazole for reating echinococcosis[D]. Urumqi:Xinjiang Medical University, 2011. (in Chinese) 李海涛.阿苯达唑脂质体治疗包虫病的临床研究[D].乌鲁木齐:新疆医科大学, 2011.

[13]ALANAZI FK, EL-BADRY M, AHMED MO, et al. Improvement of albendazole dissolution by preparing microparticles using spray-drying technique[J]. Sci Pharm, 2007, 75 (75) :63-79.

[14]BALDRICK P. The safety of chitosan as a pharmaceutical excipient[J]. Requl Toxicol Pharmacol, 2010, 56 (3) :290-299.

[15]LIANG HF, YANG TF, HUANG CT, et al. Preparation of nanoparticles composed of poly (γ-glutamic acid) -poly (lactide) block copolymers and evaluation of their uptake by HepG2cells[J]. J Control Release, 2005, 105 (3) :213-225.

[16]LIU Y, WANG XQ, REN WX, et al. Novel albendazole-chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats[J]. J Biomed Mater RES, 2013, 101B (6) :998-1005.

[17]LIANG W, WANG XC, WU XW, et al. Efficacy of albendazole chitosan microspheres against echinococcus granulosus infection in mice[J]. Chin J Parasitol Parasit Dis, 2014, 32 (2) :188-192. (in Chinese) 梁闻, 王新春, 吴向未, 等.阿苯达唑壳聚糖微球抗小鼠细粒棘球蚴药效实验研究[J].中国寄生虫学与寄生虫病杂志, 2014, 32 (2) :188-192.

[18]SCHIPPER HG, KOOPMANS RP, NAGY J, et al. Effect of dose increase or cimetidine co-administration on albendazole bioavailability[J]. Am J Trop Med Hyg, 2000, 63 (6) :270-273.

[19]BEKHTI A, PIROTTE J. Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts[J]. Br J Clin Pharmacol, 2012, 24 (3) :390-392.

[20]KANG JF, XUE HX, YANG WG, et al. Therapeutic effect of peganum harmala seed on cystic hydatid and alveolar hydatid in abdominal cavity of mouse[J]. Acta Acad Med Xinjiang, 1993, 16 (3) :178-181. (in Chinese) 康金风, 薛弘燮, 杨文光, 等.骆驼蓬籽治疗小鼠腹腔棘球蚴和泡球蚴的效果[J].新疆医学院学报, 1993, 16 (3) :178-181.

[21]ZHAO JM, YANG WG, MA XM. Experimental study on combination chemotherapy of echinococcus granulosus in mice with peganum harmala. L, harmine and albendazole[J]. J Xinjiang Med Univ, 2001, 24 (2) :125-127. (in Chinese) 赵晋明, 杨文光, 马新民.骆驼蓬总碱治疗小鼠腹腔细粒棘球蚴病的实验研究[J].新疆医科大学学报, 2001, 24 (2) :125-127.

[22]LI LH, ZHAO J, MA YF, et al. Experimental study of harmine and albendazole on Echinococcosis infection in mice[J]. J Pathog Biol, 2016, 11 (9) :815-820. (in Chinese) 李丽华, 赵军, 马运芳, 等.去氢骆驼蓬碱和阿苯达唑联合治疗小鼠腹腔细粒棘球蚴病的实验研究[J].中国病原生物学杂志, 2016, 11 (9) :815-820.

[23]WANG ZJ, LI YR, WU WC, et al. Research progress of pharmacological effects of Artemisia annua L. and its derivatives[J]. Guangxi Med J, 2018, 40 (10) :1222-1224. (in Chinese) .王子见, 李怡瑞, 吴文成, 等.青蒿素及其衍生物的药理学作用研究进展[J].广西医学, 2018, 40 (10) :1222-1224.

[24]ZHANG HW, PENG XY, WU XW, et al. Effects of three dosage of artesunate on anti-echinococcosis in mice[J]. Chin J Zoonoses, 2015, 31 (1) :41-44. (in Chinese) 张宏伟, 彭心宇, 吴向未, 等. 3种不同剂量的青蒿琥酯抗小鼠细粒棘球蚴疾病作用的比较[J].中国人兽共患病学报, 2015, 31 (1) :41-44.

[25]LI T, CHEN H, MEI X, et al. The immunosuppressive and regulatory mechanism of artemisinin[J]. Chin Pharmacol Bull, 2011, 27 (6) :848-854. (in Chinese) 李覃, 陈虹, 梅昕, 等.青蒿素的免疫抑制作用及其调控机制研究[J].中国药理学通报, 2011, 27 (6) :848-854.

[26]BAO GS, SHI DZ, MA XM. Effect of alkaloids from Sophora moorcroftiana on Echinococcus granulosus in mice[J]. Chin J Parasitol Parasit Dis, 2005, 23 (6) :471-472. (in Chinese) 包根书, 史大中, 马兴铭.砂生槐生物碱抗小鼠细粒棘球蚴作用的初步观察[J].中国寄生虫学与寄生虫病杂志, 2005, 23 (6) :471-472.

[27]LUO YP. The research of effects and mechanisms of alkaloidal fractions from Sophora moorcroftiana seeds against Echinococcus[D]. Lanzhou:Lanzhou University, 2017. (in Chinese) 雒艳萍.砂生槐种子生物碱抗包虫效应及机制研究[D].兰州:兰州大学, 2017.

[28]CHEN G, SHI DZ, LI WK. Effect of tetrandrine and albendazole on Echinococcus multilocularis infection in mice[J].Chin J Zoonoses, 2002, 18 (6) :69-72. (in Chinese) 陈根, 史大中, 李文科.汉防己甲素和阿苯达唑治疗小鼠继发性泡球蚴病的疗效观察[J].中国人兽共患病学报, 2002, 18 (6) :69-72.

[29]BAO GS, SHI DZ, CHEN G. Observation on the effect of tetrandrine and albendazole against Echinococcus granulosus in vitro[J]. Endemic Dis Bull, 2003, 18 (2) :16-17. (in Chinese) 包根书, 史大中, 陈根.汉防己甲素和阿苯达唑体外抗细粒棘球蚴原头节作用的观察[J].地方病通报, 2003, 18 (2) :16-17.

[30]MA JY, BARGER MW, HUBBS AF, et al. Use of tetrandrine to differentiate between mechanisms involved in silica-versus bleomycin-induced fibrosis[J]. J Toxicol Environ Health A, 1999, 57 (4) :247-266.

[31]MOAZENI M, NAZER A. In vitro effectiveness of garlic (allium sativum) extract on scolices of hydatid cyst[J]. World J Surg, 2010, 34 (11) :2677-2681.

[32]ALI NM, IBRAHIM AN, AHMED NS. Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice[J]. J Parasit Dis, 2016, 40 (3) :893-900.

[33]MOAZENI M, ROOZITALAB A. High scolicidal effect of Zataria multiflora on protoccoleces of hydatid cyst:An in vitro study[J]. Comp Clin Pathol, 2012, 21 (1) :99-104.

[34]KAVOOSI G, PURFARD AM. Scolicidal effectiveness of essential oil from Zataria multiflora and Ferula assafoetida:Disparity between phenolic monoterpenes and disulphide compounds[J]. Comp Clin Pathol, 2013, 22 (5) :999-1005.

[35]AL-MAYAH KS, AL-BASHIR NM, AL-AZZAWI BM, et al.In vivo efficacy of nigella sativa aqueous seed extract against metacestode of echinococcus granulosus[J]. Med J Babylon, 2014, (1) :140-151.

[36]MAHMOUDVAND H, DEZAKI ES, KHEIRANDISH F, et al. Scolicidal effects of black cumin seed (Nigella sativa) essential oil on hydatid cysts[J]. Korean J Parasitol, 2014, 52 (6) :653.

[37]ROUHANI S, SALEHI N, KAMALINEJAD M, et al. Efficacy of Berberis vulgaris aqueous extract on viability of Echinococcus granulosus protoscolices[J]. J Invest Sura, 2013, 26 (6) :347-351.

[38]MAHMOUDVAND H, DEZAKI ES, SHARIFIFAR F, et al. Protoscolecidal effect of berberis vulgaris root extract and its main compound, berberine in cystic echinococcosis[J]. Iran J Parasitol, 2014, 9 (4) :503-510.

[39]MOAZENI M, SAHARKHIZ MJ, HOSSEINI AA. In vitro lethal effect of ajowan (Trachyspermum ammi L.) essential oil on hydatid cyst protoscoleces[J]. Vet Parasitol, 2012, 187 (1-2) :203-208.

[40]LATEEF M, IQBAL Z, AKHTAR MS, et al. Preliminary screening of Trachyspermum ammi (L.) seed for anthelmintic activity in sheep[J]. Trop Anim Health Prod, 2006, 38 (6) :491-496.

[41]EDYTA K, ELZ·BIETA C, ADAM K, et al. Insecticidal activity of Bacillus thuringiensis crystals and thymol mixtures[J]. Int J Surg, 2018, 117 (3) :272-277.

[42]MAHMOUDVAND H, FASIHI HARANDI M, SHAKIBAIE M, et al. Scolicidal effects of biogenic selenium nanoparticles against protoscolices of hydatid cysts[J]. Int J Surg, 2014, 12 (5) :399-403.

[43]RAHIMI MT, AHMADPOUR E, ESBOEI BR, et al. Scolicidal activity of biosynthesized silver nanoparticles against Echinococcus granulosus protoscolices[J]. Int J Surg, 2015, 19:128-133.

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