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血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值对肝细胞癌射频消融术后长期存活患者的预后评估价值

张洪海 孙玉 生守鹏 李聪 孙斌 张英华 扈彩霞 崔雄伟 李星明 张永宏 郑加生

张洪海, 孙玉, 生守鹏, 李聪, 孙斌, 张英华, 扈彩霞, 崔雄伟, 李星明, 张永宏, 郑加生. 血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值对肝细胞癌射频消融术后长期存活患者的预后评估价值[J]. 临床肝胆病杂志, 2019, 35(5): 1014-1020. DOI: 10.3969/j.issn.1001-5256.2019.05.016.
引用本文: 张洪海, 孙玉, 生守鹏, 李聪, 孙斌, 张英华, 扈彩霞, 崔雄伟, 李星明, 张永宏, 郑加生. 血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值对肝细胞癌射频消融术后长期存活患者的预后评估价值[J]. 临床肝胆病杂志, 2019, 35(5): 1014-1020. DOI: 10.3969/j.issn.1001-5256.2019.05.016.
Zhang HongHai, Sun Yu, Sheng ShouPeng, Li Cong, Sun Bin, Zhang YingHua, Hu CaiXia, Cui XiongWei, Li XingMing, Zhang YongHong, Zheng JiaSheng. Value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in prognostic evaluation of patients with long-term survival after radiofrequency ablation for hepatocellular carcinoma[J]. J Clin Hepatol, 2019, 35(5): 1014-1020. DOI: 10.3969/j.issn.1001-5256.2019.05.016.
Citation: Zhang HongHai, Sun Yu, Sheng ShouPeng, Li Cong, Sun Bin, Zhang YingHua, Hu CaiXia, Cui XiongWei, Li XingMing, Zhang YongHong, Zheng JiaSheng. Value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in prognostic evaluation of patients with long-term survival after radiofrequency ablation for hepatocellular carcinoma[J]. J Clin Hepatol, 2019, 35(5): 1014-1020. DOI: 10.3969/j.issn.1001-5256.2019.05.016.

血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值对肝细胞癌射频消融术后长期存活患者的预后评估价值

DOI: 10.3969/j.issn.1001-5256.2019.05.016
基金项目: 

国家自然科学基金资助项目(81472328); 

详细信息
  • 中图分类号: R735.7

Value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in prognostic evaluation of patients with long-term survival after radiofrequency ablation for hepatocellular carcinoma

Research funding: 

 

  • 摘要: 目的探讨血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)对射频消融术后生存期超过5年的肝细胞癌(HCC)患者预后评估价值。方法选取2006年6月-2012年2月于首都医科大学附属北京佑安医院行经肝动脉化疗栓塞术联合射频消融治疗且生存期超过5年的肝细胞癌患者135例。收集所有患者基线实验室及影像检查资料,根据血常规结果计算NLR与PLR。计数资料组间比较采用χ2检验。采用受试者工作特征曲线(ROC曲线)确定NLR、PLR临界值,Kaplan-Meier法绘制生存曲线,log-rank检验比较生存率,将log-rank检验分析中具有统计学差异的指标纳入Cox多因素分析。结果根据ROC曲线,确定NLR临界值为2. 08,PLR临界值为96. 82。按照治疗前NLR、PLR临界值分为:低NLR组(NLR <2. 08,n=60)与高NLR组(NLR≥2. 08,n=75),低PLR组(PLR <96. 82,n=78)与高PLR组(PLR≥96. 82,n=57),结果显示低NLR组与高NLR组患者AFP、巴塞罗那分期差异均有统计学意义(χ<...

     

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  • 收稿日期:  2018-11-12
  • 出版日期:  2019-05-20
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