蛋白磷酸酶2A在肝细胞癌中的促进与抑制作用机制

杨成雷; 黄燊; 张志明

doi:10.3969/j.issn.1001-5256.2019.05.044

蛋白磷酸酶2A在肝细胞癌中的促进与抑制作用机制

DOI: 10.3969/j.issn.1001-5256.2019.05.044

广西医科大学附属肿瘤医院肝胆外科

基金项目:

广西教育厅中青年教师基础能力提升项目(KY2016YB085)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2018-12-17
- 出版日期: 2019-05-20

Mechanism of action of protein phosphatase 2A in the promotion and inhibition of hepatocellular carcinoma

Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital of Guangxi Medical University

Research funding:

摘要

摘要: 蛋白磷酸酶2A(PP2A)是一种主要的丝氨酸/苏氨酸磷酸酶,参与细胞生长和增殖相关的许多信号传导途径,并调节许多细胞过程。随着对PP2A在细胞活动(尤其恶性肿瘤)过程中的深入探索,其与肝细胞癌(HCC)的关系也引起了越来越多的关注和研究。PP2A对HCC的调节作用是促进还是抑制,目前仍然存在较大争议。探讨了现阶段PP2A作为肿瘤因子调控HCC的作用机制和靶点治疗的研究进展。
- 癌,肝细胞 /
- 蛋白质磷酸酶2 /
- 基因表达调控 /
- 综述
Abstract: Protein phosphatase 2A ( PP2A) is a major serine/threonine phosphatase involved in many signaling pathways associated with cell growth and proliferation, and it also regulates many cellular processes. With an in-depth exploration of PP2A in the process of cell activity, especially malignant tumors, the association between PP2A and hepatocellular carcinoma ( HCC) has attracted more and more attention in recent years; however, there is still a controversy over whether PP2A can promote or inhibit HCC. This article reviews the research advances in the mechanism of action of PP2A as a tumor factor in the regulation of HCC and target therapy.
- carcinoma, hepatocellular /
- protein phosphatase 2 /
- gene expression regulation /
- review

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参考文献(64)

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