自噬在急性胰腺炎发生发展中的作用

李春云; 刘瑞霞; 阴赪宏

doi:10.3969/j.issn.1001-5256.2019.05.051

自噬在急性胰腺炎发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2019.05.051

1. 首都医科大学附属北京妇产医院内科
2. 首都医科大学附属北京妇产医院中心实验室

基金项目:

国家自然科学基金资助项目(81571933)；

详细信息

中图分类号: R576
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- 被引次数: 0
出版历程
- 收稿日期: 2018-11-02
- 出版日期: 2019-05-20

The role of autophagy in the development and progression of acute pancreatitis

Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University

Research funding:

摘要

摘要: 急性胰腺炎(AP)是一种胰腺外分泌部炎症性疾病,其发病的病理生理机制尚不清楚。自噬是细胞内代谢降解的一个重要途径,自噬损伤与许多疾病的发生发展密切相关。近来研究发现,AP中自噬过程发生明显异常,自噬体与溶酶体融合障碍,自噬溶酶体降解功能显著下降。胰腺内胰酶异常激活与炎症反应是启动AP的关键事件,而自噬功能异常与二者皆密切相关。对AP自噬功能障碍的上下游机制进行探究,有助于发现治疗胰腺炎新的分子目标和策略。
- 胰腺炎 /
- 自噬 /
- 溶酶体相关膜糖蛋白质类 /
- 炎症 /
- 综述
Abstract: Acute pancreatitis ( AP) is an exocrine inflammatory disease of the pancreas, the pathophysiological mechanism of AP remains unclear. Autophagy is an important pathway of metabolic degradation in cells, and autophagy impairment is closely associated with the development and progression of many diseases. Recent studies have found that the process of autophagy is abnormal in AP, with impaired fusion of autophagosome and lysosome and a significant reduction in the degradation function of autolysosome. Abnormal activation of pancreatic enzymes and inflammatory response is the key event in the initiation of AP, and abnormal autophagy is closely associated with these two events.The study of the upstream and downstream mechanisms of autophagy dysfunction in AP may help to find new molecular targets and strategies for the treatment of AP.
- pancreatitis /
- autophagy /
- tysosome-associated membrane glycoproteins /
- inflammation /
- review

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参考文献(36)

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