《2019年欧洲肝病学会临床实践指南:药物性肝损伤》精粹及评析

于乐成; 赖荣陶; 陈成伟

doi:10.3969/j.issn.1001-5256.2019.06.013

《2019年欧洲肝病学会临床实践指南:药物性肝损伤》精粹及评析

DOI: 10.3969/j.issn.1001-5256.2019.06.013

1. 东部战区总医院南京中医药大学附属八一医院全军肝病中心
2. 上海交通大学医学院附属瑞金医院感染病科
3. 海军军医大学附属九○五医院临床肝病研究中心

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2019-06-20

Key points and interpretation of EASL clinical practice guidelines: Drug-induced liver injury (2019)

Liver Diseases Center of PLA, General Hospital of Eastern Theater Command & Bayi Hospital Affiliated to Nanjing University of Chinese Medicine

摘要

摘要: <正>全球对药物性肝损伤（DILI）的关注日益增加。欧洲肝病学会（EASL）于2019年2月正式发布了《EASL临床实践指南:药物性肝损伤》（简称EASL指南）[1]。这是继美国胃肠病学会（ACG）在2014年首次发布《ACG临床指南:特异质性药物性肝损伤的诊断和处理》（简称ACG指南）[2]、中华医学会肝病学分会（CSH）在2015年首次发布《药物性肝损伤诊治指南》（简称CSH指南）[3]并在
- 药物性肝损伤 /
- 欧洲 /
- 诊疗准则
- drug-induced liver injury /
- Europe /
- practice guideline

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参考文献(8)

[1]European Association for the Study of the Liver.EASL clinical practice guidelines:Drug-induced liver injury[J].J Hepatol, 2019.[Epub ahead of print]

[2]CHALASANI NP, HAYASHI PH, BONKOVSKY HL, et al.ACGclinical guideline:The diagnosis and management of idiosyncratic drug-induced liver injury[J].Am J Gastroenterol, 2014, 109 (7) :950-966.

[3]Drug-induced Liver Disease Study Group, Chinese Society of Hepatology, Chinese Medical Association.Guidelines for the management of drug-induced liver injury[J].J Clin Hepatol, 2015, 31 (11) :1752-1769. (in Chinese) 中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志, 2015, 31 (11) :1752-1769.

[4]YU YC, MAO YM, CHEN CW, et al.CSH guideline for the diagnosis and treatment of drug-induced liver injury[J].Hepatol Int, 2017, 11 (3) :221-241.

[5]FONTANA RJ, WATKINS PB, BONKOVSKY HL, et al.DrugInduced Liver Injury Network (DILIN) prospective study:Rationale, design and conduct[J].Drug Saf, 2009, 32 (1) :55-68.

[6]AITHAL GP, WATKINS PB, ANDRADE RJ, et al.Case definition and phenotype standardization in drug-induced liver injury[J].Clin Pharmacol Ther, 2011, 89 (6) :806-815.

[7]MEDINA-CALIZ I, ROBLES-DIAZ M, GARCIA-MUOZ B, et al.Spanish DILI registry.Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury[J].J Hepatol, 2016, 65 (3) :532-542.

[8]YU YC, FAN Y, CHEN CW.Criteria for chronicity of drug-induced liver injury:3 or 6 months or 1 year?[J].Chin Hepatol, 2017, 22 (2) :97-100. (in Chinese) 于乐成, 范晔, 陈成伟.药物性肝损伤慢性化判断标准:3或6个月还是1年?[J].肝脏, 2017, 22 (2) :97-100.

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