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肝脏硬度值对HBeAg阳性慢性HBV感染者肝纤维化程度的诊断价值

刘娜 李春霞 东冰 周路路 张瑞芹 赵英仁 何英利 徐光华

李甜甜, 孙静, 王权, 丁俊强, 王佳, 薛慧, 张弢, 段学章. 小肝癌立体定向放射治疗的效果及预后分析[J]. 临床肝胆病杂志, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
引用本文: 李甜甜, 孙静, 王权, 丁俊强, 王佳, 薛慧, 张弢, 段学章. 小肝癌立体定向放射治疗的效果及预后分析[J]. 临床肝胆病杂志, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
Li TianTian, Sun Jing, Wang Quan, Ding JunQiang, Wang Jia, Xue Hui, Zhang Tao, Duan XueZhang. Clinical effect of stereotactic body radiotherapy in treatment of patients with small hepatocellular carcinoma and related prognostic factors[J]. J Clin Hepatol, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
Citation: Li TianTian, Sun Jing, Wang Quan, Ding JunQiang, Wang Jia, Xue Hui, Zhang Tao, Duan XueZhang. Clinical effect of stereotactic body radiotherapy in treatment of patients with small hepatocellular carcinoma and related prognostic factors[J]. J Clin Hepatol, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.

肝脏硬度值对HBeAg阳性慢性HBV感染者肝纤维化程度的诊断价值

DOI: 10.3969/j.issn.1001-5256.2019.06.016
基金项目: 

延安市科技惠民计划(2014HM-09); 

详细信息
  • 中图分类号: R512.62;R575.2

Value of liver stiffness measurement in the diagnosis of liver fibrosis degree in HBeAg-positive patients with chronic HBV infection

Research funding: 

 

  • 摘要: 目的评估肝脏硬度值(LSM)对HBeAg阳性慢性HBV感染者肝纤维化程度的诊断价值。方法采用回顾性研究方法,纳入2013年10月-2018年8月在延安大学附属医院住院行肝活组织检查的HBeAg阳性慢性HBV感染者330例,根据肝组织学病理结果,分为轻微肝纤维化(F0~F1)和明显肝纤维化(F2~F4)两组。计量资料两组间比较采用t检验或非参数Mann-Whitney U检验,计数资料两组间比较采用χ2检验。通过logistic单因素及多因素分析筛选诊断明显肝纤维化的指标,然后对筛选后的指标绘制受试者工作特征(ROC)曲线评估其在诊断明显肝纤维化患者中的预测价值。结果 330例患者中轻微纤维化(F0~F1)有245例,明显肝纤维化(F2~F4)有85例。两组在临床指标HBV DNA、HBsAg、HBeAg、抗-HBc、ALT、AST、TBil和LSM水平上比较差异均有统计学意义(P值均<0. 05)。多因素分析显示,HBsAg与LSM是明显肝纤维化的独立危险因素(P值均<0. 05)。ROC曲线分析发现只有LSM有诊断价值,ROC曲线下面积为0. 744...

     

  • [1]SCHWEITZER A, HORN J, MIKOLAJCZYK RT, et al.Estimations of worldwide prevalence of chronic hepatitis B virus infection:A systematic review of data published between 1965 and2013[J].Lancet, 2015, 386 (10003) :1546-1555.
    [2]European Association for the Study of the Liver.EASL clinical practice guidelines:Management of chronic hepatitis B virus infection[J].J Hepatol, 2012, 57 (1) :167-185.
    [3]TERRAULT NA, LOK ASF, McMAHON BJ, et al.Update on prevention, diagnosis, and treatment of chronic hepatitis B:AASLD 2018 hepatitis B guidance[J].Hepatology, 2018, 67 (4) :1560-1599.
    [4]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B:A 2015 update[J].J Clin Hepatol, 2015, 31 (12) :1941-1960. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2015年更新版) [J].临床肝胆病杂志, 2015, 31 (12) :1941-1960.
    [5]CAVIGLIA GP, ABATE ML, PELLICANO R, et al.Chronic hepatitis B therapy:Available drugs and treatment guidelines[J].Minerva Gastroenterol Dietol, 2015, 61 (2) :61-70.
    [6]DENG GH, WANG ZL, WANG YM, et al.Dynamic determination and analysis of serum virus load in patients with chronic HBV infection[J].World Chin J Dig, 2004, 12 (4) :862-865. (in Chinese) 邓国宏, 王宗笠, 王宇明, 等.慢性HBV感染者血清病毒动力学的检测及分析[J].世界华人消化杂志, 2004, 12 (4) :862-865.
    [7]SHARAIHA RZ, KUMTA NA, SAUMOY M, et al.Endoscopic sleeve gastroplasty significantly reduces body mass index and metabolic complications in obese patients[J].Clin Gastroenterol Hepatol, 2017, 15 (4) :504-510.
    [8]OU H, CAI S, LIU Y, et al.A noninvasive diagnostic model to assess nonalcoholic hepatic steatosis in patients with chronic hepatitis B[J].Therap Adv Gastroenterol, 2017, 10 (2) :207-217.
    [9]PENG J, CAI S, YU T, et al.Aspartate aminotransferase to platelet ratio index-a reliable predictor of therapeutic efficacy and improvement of Ishak score in chronic hepatitis B patients treated with nucleoside analogues[J].Scand J Clin Lab Invest, 2016, 76 (2) :133-142.
    [10]BRAVO AA, SHETH SG, CHOPRA S.Liver biopsy[J].N Engl J Med, 2001, 344 (7) :495-500.
    [11]BEDOSSA P, POYNARD T.An algorithm for the grading of activity in chronic hepatitis C.The METAVIR Cooperative Study Group[J].Hepatology, 1996, 24 (2) :289-293.
    [12]CASTERA L, FORNS X, ALBERTI A.Non-invasive evaluation of liver fibrosis using transient elastography[J].J Hepatol, 2008, 48 (5) :835-847.
    [13]European Association for Study of Liver, Asociacion Latinoamericana para el Estudio del Higado.EASL-ALEH clinical practice guidelines:Non-invasive tests for evaluation of liver disease severity and prognosis[J].J Hepatol, 2015, 63 (1) :237-264.
    [14]CAO FM, ZHANG ZR, WANG X.The study correlation between liver stiffness and pathological staging of liver biopsy in patients with chronic hepatitis B by Fibroscan[J].Hebei Medicine, 2018, 24 (7) :1223-1226. (in Chinese) 曹发明, 张照如, 王翔.Fibroscan测定慢性乙型肝炎患者肝硬度值与肝组织活检病理学分期的相关性研究[J].河北医学, 2018, 24 (7) :1223-1226.
    [15] DUAN WJ, WANG XM, WANG Y, et al.Comparison of FibroTouch and FibroScan for the assessment of fibrosis in chronic hepatitis B patients[J].Chin J Exp Clin Virol, 2018, 32 (4) :399-402. (in Chinese) 段维佳, 王晓明, 王宇, 等.FibroTouch和FibroScan检测评估慢性乙型肝炎患者肝纤维化程度的诊断价值[J].中华实验和临床病毒学杂志, 2018, 32 (4) :399-402.
    [16]TAN YW, ZHOU XB, YE Y, et al.Diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase[J].World JGastroenterol, 2017, 23 (31) :5746-5754.
    [17]ZHANG XY, QIAN J, HOU W, et al.Clinical value of diagnosing hepatic fibrosis by Mohamadnejad model and FibroScan in the HBe Ag negative chronic hepatitis B virus carriers[J].Chin J Exp Clin Virol, 2018, 32 (1) :70-74. (in Chinese) 张孝盈, 钱静, 侯伟, 等.利用Mohamadnejad模型和FibroScan诊断HBe Ag阴性慢性HBV携带者肝纤维化的临床价值[J].中华实验和临床病毒学杂志, 2018, 32 (1) :70-74.
    [18]CHAN AO, YUEN MF, LAM CM, et al.Prevalence and characteristics of familial hepatocellular carcinoma caused by chronic hepatitis B infection in Hong Kong[J].Aliment Pharmacol Ther, 2004, 19 (4) :401-406.
    [19]LIN CL, KAO JH.Review article:The prevention of hepatitis B-related hepatocellular carcinoma[J].Aliment Pharmacol T-her, 2018, 48 (1) :5-14.
    [20]ZHOU JL, WU XN, SUN YM, et al.Progress in clinical studies of noninvasive early diagnosis of liver fibrosis and cirrhosis[J].JClin Hepatol, 2018, 34 (8) :1674-1677. (in Chinese) 周家玲, 吴晓宁, 孙亚朦, 等.ALT水平对乙型肝炎肝硬化患者肝脏硬度值的影响[J].临床肝胆病杂志, 2018, 34 (8) :1674-1677.
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  • 收稿日期:  2019-01-14
  • 出版日期:  2019-06-20
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