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肝脏硬度值对HBeAg阳性慢性HBV感染者肝纤维化程度的诊断价值

刘娜 李春霞 东冰 周路路 张瑞芹 赵英仁 何英利 徐光华

王宇喆, 尹化斌. iFlow彩色编码技术实时定量测定肝细胞癌经肝动脉化疗栓塞术前后血流动力学改变的可行性探讨[J]. 临床肝胆病杂志, 2018, 34(1): 133-136. DOI: 10.3969/j.issn.1001-5256.2018.01.027.
引用本文: 王宇喆, 尹化斌. iFlow彩色编码技术实时定量测定肝细胞癌经肝动脉化疗栓塞术前后血流动力学改变的可行性探讨[J]. 临床肝胆病杂志, 2018, 34(1): 133-136. DOI: 10.3969/j.issn.1001-5256.2018.01.027.
Wang YuZhe, Yin HuaBin. Feasibility of i Flow color-coding technique in quantitative real-time measurement of hemodynamic changes after transarterial chemoembolization for hepatocellular carcinoma[J]. J Clin Hepatol, 2018, 34(1): 133-136. DOI: 10.3969/j.issn.1001-5256.2018.01.027.
Citation: Wang YuZhe, Yin HuaBin. Feasibility of i Flow color-coding technique in quantitative real-time measurement of hemodynamic changes after transarterial chemoembolization for hepatocellular carcinoma[J]. J Clin Hepatol, 2018, 34(1): 133-136. DOI: 10.3969/j.issn.1001-5256.2018.01.027.

肝脏硬度值对HBeAg阳性慢性HBV感染者肝纤维化程度的诊断价值

DOI: 10.3969/j.issn.1001-5256.2019.06.016
基金项目: 

延安市科技惠民计划(2014HM-09); 

详细信息
  • 中图分类号: R512.62;R575.2

Value of liver stiffness measurement in the diagnosis of liver fibrosis degree in HBeAg-positive patients with chronic HBV infection

Research funding: 

 

  • 摘要: 目的评估肝脏硬度值(LSM)对HBeAg阳性慢性HBV感染者肝纤维化程度的诊断价值。方法采用回顾性研究方法,纳入2013年10月-2018年8月在延安大学附属医院住院行肝活组织检查的HBeAg阳性慢性HBV感染者330例,根据肝组织学病理结果,分为轻微肝纤维化(F0~F1)和明显肝纤维化(F2~F4)两组。计量资料两组间比较采用t检验或非参数Mann-Whitney U检验,计数资料两组间比较采用χ2检验。通过logistic单因素及多因素分析筛选诊断明显肝纤维化的指标,然后对筛选后的指标绘制受试者工作特征(ROC)曲线评估其在诊断明显肝纤维化患者中的预测价值。结果 330例患者中轻微纤维化(F0~F1)有245例,明显肝纤维化(F2~F4)有85例。两组在临床指标HBV DNA、HBsAg、HBeAg、抗-HBc、ALT、AST、TBil和LSM水平上比较差异均有统计学意义(P值均<0. 05)。多因素分析显示,HBsAg与LSM是明显肝纤维化的独立危险因素(P值均<0. 05)。ROC曲线分析发现只有LSM有诊断价值,ROC曲线下面积为0. 744...

     

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  • 收稿日期:  2019-01-14
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