沉默信息调节因子1在肝脏缺血再灌注损伤中的作用

王敬元; 李生伟; 龚建平; 江德全

doi:10.3969/j.issn.1001-5256.2019.06.047

沉默信息调节因子1在肝脏缺血再灌注损伤中的作用

DOI: 10.3969/j.issn.1001-5256.2019.06.047

1. 重庆医科大学附属第二医院肝胆外科
2. 重庆市江津区中心医院普外科

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2018-11-19
- 出版日期: 2019-06-20

Role of silent information regulator 1 in hepatic ischemia-reperfusion injury

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University

摘要

摘要: 肝脏缺血再灌注损伤一直是肝移植及肝脏肿瘤切除等手术中面临的难题,多种机制的参与使其变得尤为复杂,其中缺血期间的能量消耗和再灌注诱导的氧化应激是导致肝脏缺血再灌注损伤的主要机制,二者共同导致细胞死亡甚至引发肝衰竭。沉默信息调节因子(Sirt)是一类具有烟酰胺腺嘌呤二核苷酸依赖性的脱乙酰化酶,可使组蛋白及非组蛋白等转录因子脱乙酰化,在细胞凋亡、炎症反应、能量平衡及氧化应激等方面发挥重要的调节作用,哺乳动物体内沉默信息调节因子有7种,包括Sirt1～Sirt7,其中,Sirt1可通过多种信号通路来减轻肝细胞应激并调控细胞代谢途径,从而达到减轻肝脏缺血再灌注损伤程度的目的,主要对Sirt1相关信号通路在肝脏缺血再灌注损伤中的作用进行了综述。
- Ⅲ型组蛋白脱乙酰基酶类 /
- 再灌注损伤 /
- 肝疾病 /
- 综述
Abstract: Hepatic ischemia-reperfusion injury has always been a difficult problem in liver transplantation and liver tumor resection. The involvement of multiple mechanisms makes it particularly complex, among which energy expenditure during ischemia and oxidative stress induced by reperfusion are the main mechanisms leading to hepatic ischemia-reperfusion injury and may cause cell death and even liver failure. Silent information regulators are a class of nicotinamide adenine dinucleotide-dependent deacetylases which can lead to deacetylation of transcription factors including histones and nonhistones, and they are playing an important regulatory role in cell apoptosis, inflammatory response, energy balance, and oxidative stress. There are 7 types of silent information regulators in mammals, i. e., Sirt1-Sirt7, among which Sirt1 can reduce hepatocyte stress, regulate cell metabolic pathways, and thus alleviate the degree of hepatic ischemia-reperfusion injury through various signaling pathways. This article reviews the role of Sirt1-related signaling pathways in hepatic ischemia-reperfusion injury.
- group Ⅲ histone deacetylases /
- reperfusion injury /
- liver diseases /
- review

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