自身免疫性肝炎相关自身抗体及临床意义

雪梅; 沈怡; 沈梦益; 凡小丽; 门若庭; 杨丽

doi:10.3969/j.issn.1001-5256.2019.06.048

自身免疫性肝炎相关自身抗体及临床意义

DOI: 10.3969/j.issn.1001-5256.2019.06.048

基金项目:

国家自然科学基金(81770568)；

详细信息

中图分类号: R575.1
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- 被引次数: 0
出版历程
- 收稿日期: 2018-11-19
- 出版日期: 2019-06-20

Autoimmune hepatitis-related autoantibodies and their clinical significance

Research funding:

摘要

摘要: 自身免疫性肝炎（AIH）是一种靶向肝细胞、自身免疫反应介导的肝脏实质炎症,以血清中存在自身抗体及高IgG和（或）高γ-球蛋白血症为特征。大多数AIH患者血清中存在一种或多种自身抗体,这些自身抗体是AIH的重要特征和诊断的重要依据,部分自身抗体还与AIH的不同临床表现、疾病活动、治疗应答以及预后相关。对AIH相关自身抗体及其临床意义进行了探讨。
- 肝炎,自身免疫性 /
- 自身抗体 /
- 综述
Abstract: Autoimmune hepatitis (AIH) is an autoimmune response-mediated liver parenchymal inflammation targeting hepatocytes, with the features of autoantibodies in serum, a high serum level of immunoglobulin G, and/or hypergammaglobulinemia. Most AIH patients have one or more autoantibodies in serum, and these antibodies are important features of AIH and the basis for the diagnosis of AIH. Some antibodies are also associated with the clinical manifestations, disease activity, therapeutic response, and prognosis of AIH. This article reviews AIH-related autoantibodies and their clinical significance.
- hepatitis, autoimmune /
- autoantibodies /
- review

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参考文献(46)

[1]CZAJA AJ.Global disparities and their implications in the occurrence and outcome of autoimmune hepatitis[J].Dig Dis Sci, 2017, 62 (9) :2277-2292.

[2]CHRISTEN U, HINTERMANN E.Pathogens and autoimmune hepatitis[J].Clin Exp Immunol, 2019, 195 (1) :35-51.

[3]MIELI-VERGANI G, VERGANI D, CZAJA AJ, et al.Autoimmune hepatitis[J].Nat Rev Dis Primers, 2018, 4:18017.

[4]SCHMELTZER PA, RUSSO MW.Clinical narrative:Autoimmune hepatitis[J].Am J Gastroenterol, 2018, 113 (7) :951-958.

[5]European Association for the Study of the Liver.EASL clinical practice guidelines:Autoimmune hepatitis[J].J Hepatology, 2015, 63 (4) :971-1004.

[6]CZAJA AJ.Diagnosis and management of autoimmune hepatitis:Current status and future directions[J].Gut Liver, 2016, 10 (2) :177-203.

[7]CZAJA AJ.Diagnosis and management of autoimmune hepatitis[J].Clin Liver Dis, 2015, 19 (1) :57-79.

[8]LIBERAL R, KRAWITT EL, VIERLING JM, et al.Cutting edge issues in autoimmune hepatitis[J].J Autoimmune, 2016, 75:6-19.

[9]FLOREANI A, LIBERAL R, VERGANI D, et al.Autoimmune hepatitis:Contrasts and comparisons in children and adults-a comprehensive review[J].J Autoimmune, 2013, 46:7-16.

[10]LIWINSKI T, SCHRAMM C.Autoimmune hepatitis-update on clinical management in 2017[J].Clin Res Hepatology Gastroenterol, 2017, 41 (6) :617-625.

[11]SEBODE M, WELLLER-NORMANN C, LIWINSKI T, et al.Autoantibodies in autoimmune liver disease-clinical and diagnostic relevance[J].Front Immunol, 2018, 9:609.

[12]MANNS MP, LOHSE AW, VERGANI D.Autoimmune hepatitis-update 2015[J].J Hepatology, 2015, 62 (1 Suppl) :s100-s111.

[13]JIMNEZ-RIVERA C, LING SC, AHMED N, et al.Incidence and characteristics of autoimmune hepatitis[J].Pediatrics, 2015, 136 (5) :e1237-e1248.

[14]ZACHOU K, MURATORI P, KOUKOULIS GK, et al.Review article:Autoimmune hepatitis-current management and challenges[J].Aliment Pharmacol Ther, 2013, 38 (8) :887-913.

[15]GATSELIS NK, ZACHOU K, KOUKOULIS GK, et al.Autoimmune hepatitis, one disease with many faces:Etiopathogenetic, clinico-laboratory and histological characteristics[J].World J Gastroenterol, 2015, 21 (1) :60-83.

[16]CHRISTEN U, HINTERMANN E.Autoantibodies in autoimmune hepatitis:Can epitopes tell us about the etiology of the disease?[J].Front Immunol, 2018, 9:163.

[17]MACKAY IR.Autoimmune hepatitis:From the clinic to the diagnostics laboratory[J].Lab Med, 2011, 42 (4) :224-233.

[18]SAHEBJAM F, VIERLING JM.Autoimmune hepatitis[J].Front Med, 2015, 9 (2) :187-219.

[19]TERZIROLI BERETTA-PICCOLI B, MIELI-VERGANI G, VERGA-NI D.Serology in autoimmune hepatitis:A clinical-practice approach[J].Eur J Intern Med, 2018, 48:35-43.

[20]TERZIROLI BERETTA-PICCOLI B, MIELI-VERGANI G, VERGA-NI D.The clinical usage and definition of autoantibodies in immune-mediated liver disease:A comprehensive overview[J].JAutoimmune, 2018, 95:144-158.

[21]SHEN L, SURESH L.Autoantibodies, detection methods and panels for diagnosis of Sj9gren's syndrome[J].Clin Immunol, 2017, 182:24-29.

[22]LIBERAL R, MIELI-VERGANI G, VERGANI D.Clinical significance of autoantibodies in autoimmune hepatitis[J].J Autoimmune, 2013, 46:17-24.

[23]SAWALHA AH, HARLEY JB.Antinuclear autoantibodies in systemic lupus erythematosus[J].Curr Opin Rheumatol, 2004, 16 (5) :534-540.

[24]di SABATINO A, BIAGI F, LENZI M, et al.Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases[J].Dig Liver Dis, 2017, 49 (9) :947-956.

[25]WANG Q, YANG F, MIAO Q, et al.The clinical phenotypes of autoimmune hepatitis:A comprehensive review[J].J Autoimmune, 2016, 66:98-107.

[26]BERG P, STECHEMESSER E, STRIENZ J.Hypergammaglobulinmische chronisch aktive Hepatitis mit Nachweis von leber-pankreasspezifischen komplementbindenden Autoantik9rpern[J].Verh Dtsch Ges Inn Med, 1981, 87:921-927.

[27]MANNS M, GERKEN G, KYRIATSOULIS A, et al.Characterisation of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen[J].Lancet, 1987, 1 (8528) :292-294.

[28]WIES I, BRUNNER S, HENNINGER J, et al.Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis[J].Lancet, 2000, 355 (9214) :1510-1515.

[29]MURATORI P, LENZI M, CASSANI F, et al.Diagnostic approach to autoimmune hepatitis[J].Expert Rev Clin Immunol, 2017, 13 (8) :769-779.

[30]TOH BH.Diagnostic autoantibodies for autoimmune liver diseases[J].Clin Transl Immunology, 2017, 6 (5) :e139.

[31]VERGANI D, ALVAREZ F, BIANCHI FB, et al.Liver autoimmune serology:A consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group[J].J Hepatology, 2004, 41 (4) :677-683.

[32]BRAHIM I, BRAHIM I, HAZIME R, et al.Autoimmune hepatitis:Immunological diagnosis[J].Presse Med, 2017, 46 (11) :1008-1019.

[33]WANG QX, YAN L, MA X.Autoimmune hepatitis in the AsiaPacific area[J].J Clin Transl Hepatology, 2018, 6 (1) :48-56.

[34]RIZZETTO M, SWANA G, DONIACH D.Microsomal antibodies in active chronic hepatitis and other disorders[J].Clin Exp Immunol, 1973, 15 (3) :331-344.

[35]HOMBERG JC, ABUAF N, BERNARD O, et al.Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1:A second type of"autoimmune"hepatitis[J].Hepatology, 1987, 7 (6) :1333-1339.

[36]AIZAWA Y, HOKSRI A.Autoimmune hepatitis:Current challenges and future prospects[J].Clin Exp Gastroenterol, 2017, 10:9-18.

[37]MITRA S, MINZ RW.Autoantibodies in autoimmune liver diseases-methods of detection and interpretation:An update for the reporting pathologist[J].Int J Surg Pathol, 2016, 24 (7) :576-585.

[38]MARTINI E, ABUAF N, CAVALLI F, et al.Antibody to liver cytosol (anti-LC1) in patients with autoimmune chronic active hepatitis type 2[J].Hepatology, 1988, 8 (6) :1662-1666.

[39]ASHWELL G, MORELL AG.The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins[J].Adv Enzymol Relat Areas Mol Biol, 1974, 41 (0) :99-128.

[40]BELAND K, LAPIERRE P, MARCEAU G, et al.Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection[J].J Autoimmune, 2004, 22 (2) :159-166.

[41]LOHSE AW, GERKEN G, MOHR H, et al.Relation between autoimmune liver diseases and viral hepatitis:Clinical and serological characteristics in 859 patients[J].Z Gastroenterol, 1995, 33 (9) :527-533.

[42]MURATORI P, EFE C, MURATORI L, et al.Clinical implications of antimitochondrial antibody seropositivity in autoimmune hepatitis:A multicenter study[J].Eur J Gastroenterol Hepatology, 2017, 29 (7) :777-780.

[43]MURATORI P, LENZI M, MIGLIORI M, et al.Antimitochondrial antibodies positive autoimmune hepatitis with acute onset[J].Scandinavian J Gastroenterol, 2017, 52 (8) :920-921.

[44]CZAJA AJ, MORSHED SA, PARVEEN S, et al.Antibodies to single-stranded and double-stranded DNA in antinuclear antibody-positive type 1-autoimmune hepatitis[J].Hepatology, 1997, 26 (3) :567-572.

[45]NGUYEN HH, SHAHEEN AA, BAEZA N, et al.Evaluation of classical and novel autoantibodies for the diagnosis of primary biliary cholangitis-autoimmune hepatitis overlap Syndrome (PBC-AIH OS) [J].PLo S One, 2018, 13 (3) :e0193960.

[46]MURATORI P, GRANITO A, PAPPAS G, et al.The serological profile of the autoimmune hepatitis/primary biliary cirrhosis overlap syndrome[J].Am J Gastroenterol, 2009, 104 (6) :1420-1425.

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