A case of chronic drug-induced liver injury caused by psoralen decoction
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摘要: <正>1病例资料患者女性,43岁,主因"厌油、腹胀10余天,加重伴皮肤双目黄染2 d"于2017年6月10日收住延安大学附属医院。入院前10余天患者因"皮炎"口服10副中药复方汤剂(葛根30 g、乳香9 g、没药9 g、栀子6 g、天花粉30 g、灯心草6 g、薏仁30 g、补骨脂15 g、肉豆蔻15 g、吴茱萸6 g、公英15 g、知母15 g、茯苓30 g、当归15 g、升麻6 g、生地15 g),后出现厌油、腹胀,伴反酸、口苦、恶心,呕吐1次,入院前2 d家人发现其皮肤、双目黄
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Key words:
- drug-induced liver injury /
- drugs, Chinese herbal
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[1] BJORNSSON ES, BERGMANN OM, BJORNSSON HK, et al.Incidence, presentation, and outcomes in patients with druginduced liver injury in the general population of Iceland[J].Gastroenterology, 2013, 144 (7) :1419-1425, 1421-1425, e19-e20. [2] FONTANA RJ, WATKINS PB, BONKOVSKY HL, et al. DrugInduced Liver Injury Network (DILIN) prospective study:Rationale, design and conduct[J]. Drug Saf, 2009, 32 (1) :55-68. [3] CHALASANI NP, HAYASHI PH, BONKOVSKY HL, et al. ACG Clinical Guideline:The diagnosis and management of idiosyncratic drug-induced liver injury[J]. Am J Gastroenterol, 2014, 109 (7) :950-966, 967. [4] RANGNEKAR AS, FONTANA RJ. An update on drug induced liver injury[J]. Minerva Gastroenterol Dietol, 2011, 57 (2) :213-229. [5] SHEN T, LIU YX, SHANG J, et al. Incidence and etiology of drug-induced liver injury in mainland China[J]. Gastroenterology, 2019, 156 (8) :2230-2241. [6] ANDRADE RJ, LUCENA MI, FERNANDEZ MC, et al. Druginduced liver injury:An analysis of 461 incidences submitted to the Spanish registry over a 10-year period[J]. Gastroenterology, 2005, 129 (2) :512-521. [7] Drug-induced Liver Disease Study Group, Chinese Society of Hepatology, Chinese Medical Association. Guidelines for the management of drug-induced liver injury[J]. J Clin Hepatol, 2015, 31 (11) :1752-1769. (in Chinese) 中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].临床肝胆病杂志, 2015, 31 (11) :1752-1769. [8] LIU SJ. Beware of liver damage caused by traditional Chinese medicine[J]. Chin Community J, 2008, 24 (14) :23. (in Chinese) 刘士敬.警惕中药引起的肝损害[J].中国社区医师, 2008, 24 (14) :23. [9] PALMEIRA CM, ROLO AP. Mitochondrially-mediated toxicity of bile acids[J]. Toxicology, 2004, 203 (1-3) :1-15. [10] BI YN, LI Z, LU GY, et al. Effects of aqueous extract of psoralen on hepatotoxicity and bile acid transport in mice[J].Drug Eval Res, 2015, 38 (3) :267-270. (in Chinese) 毕亚男, 李震, 卢国彦, 等.补骨脂水提物对小鼠的肝毒性及胆汁酸转运的影响[J].药物评价研究, 2015, 38 (3) :267-270. [11] HAYASHI PH, BJORNSSON ES. Long-term outcomes after drug-induced liver injury[J]. Curr Hepatol Rep, 2018, 17 (3) :292-299. [12] MEDINA-CALIZ I, ROBLES-DIAZ M, GARCIA-MUOZ B, et al. Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury[J]. J Hepatol, 2016, 65 (3) :532-542. [13] FONTANA RJ, HAYASHI PH, BARNHART H, et al. Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury[J].Am J Gastroenterol, 2015, 10 (10) :1450-1459. [14] ZHOU TH, XIE Q. Progress in the study of chronic drug-induced liver injury[J]. Liver, 2018, 23 (9) :825-827. (in Chinese) 周天慧, 谢青.慢性药物性肝损伤研究进展[J].肝脏, 2018, 23 (9) :825-827. [15] YU YC, MAO YM, CHEN CW, et al. CSH guidelines for the diagnosis and treatment of drug-induced liver injury[J]. Hepatol Int, 2017, 11 (3) :221-241. [16] HOU JX, BU F, YU YC. Drug re-stimulation test for drug-induced liver injury[J]. Chin Hepatol, 2017, 22 (11) :978-982. (in Chinese) 侯俊兴, 卜凡, 于乐成.药物性肝损伤的药物再刺激试验[J].肝脏, 2017, 22 (11) :978-982. [17] YU YC, FAN Y, CHEN CW. Diagnosis and treatment of druginduced liver injury[J]. J Clin Hepatol, 2018, 34 (6) :1160-1165. (in Chinese) 于乐成, 范晔, 陈成伟.药物性肝损伤的诊断和治疗[J].临床肝胆病杂志, 2018, 34 (6) :1160-1165.
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