Numb基因在肝纤维化进展中的应用价值

胥文; 许燕楠; 刘平; 慕永平

doi:10.3969/j.issn.1001-5256.2019.08.044

Numb基因在肝纤维化进展中的应用价值

DOI: 10.3969/j.issn.1001-5256.2019.08.044

上海中医药大学附属曙光医院肝病研究所

基金项目:

国家自然科学基金面上项目(81573948,81874390)；

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 收稿日期: 2019-01-29
- 出版日期: 2019-08-20

Role of the Numb gene in the progression of liver fibrosis

Institute of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 肝纤维化是机体对创伤修复的应答反应,是各种慢性肝病走向肝硬化的必经之路,目前尚无阻断或逆转肝纤维化的化学或生物药品上市。肝纤维化的发病机制十分复杂,涉及TGFβ/Smad、Notch、Wnt、Hedgehog等多种信号通路,但如何执简驭繁仍然是治疗领域面临的关键问题。Numb,一个非常关键的细胞命运决定因子,参与Notch、Wnt、Hedgehog等信号通路的调控,但其在抗肝纤维化中的作用尚未得到充分重视,综述了Numb在抗肝纤维化中的潜在应用价值。
- 肝硬化 /
- Numb /
- 信号传导
Abstract: Liver fibrosis is the response of the body to wound repair, and it is the only way for various chronic liver diseases to develop into liver cirrhosis. At present, there is still no chemical or biological drugs for blocking or reversing liver fibrosis. Liver fibrosis has a complex pathogenesis, which involves the TGF-β/Smad, Notch, Wnt, and Hedgehog signaling pathways. However, how to use simple methods to solve this complex issue remains a key scientific problem in the treatment field. As a critical determinant for cell fate, Numb is involved in the regulation of various signaling pathways such as Notch, Wnt, and Hedgehog, but its role in anti-fibrosis has not been taken seriously.This article reviews the potential value of Numb in anti-fibrosis.
- liver cirrhosis /
- Numb /
- signal transduction

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参考文献(51)

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