脂肪性肝纤维化小鼠模型研究现状

王欣; 胡义扬; 冯琴

doi:10.3969/j.issn.1001-5256.2019.08.049

脂肪性肝纤维化小鼠模型研究现状

DOI: 10.3969/j.issn.1001-5256.2019.08.049

1 上海中医药大学附属曙光医院
2 上海市中医临床重点实验室
3 肝肾疾病病证教育部重点实验室

基金项目:

国家自然基金面上项目(81573668);国家自然基金重点项目(81830119)；国家科技重大专项“重大新药创制”项目(2018ZX09201001-001-002)；上海市科委科技创新行动计划项目(18401933100)；

详细信息

中图分类号: R575;R-332
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出版历程
- 收稿日期: 2019-05-21
- 出版日期: 2019-08-20

Current status of research on mouse models of nonalcoholic fatty liver fibrosis

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要:
脂肪性肝纤维化是目前非酒精性脂肪性肝病领域研究的重点。研究其发病机制,探索临床治疗药物是该领域亟待解决的问题之一。动物模型是基础研究的重要工具。小鼠模型因其易感性、经济性且基因组与人类高度同源,成为脂肪性肝纤维化应用最广泛的动物模型。综述了目前常用的营养因素诱发、基因敲除或突变以及多因素复合诱导的多种小鼠脂肪性肝纤维化模型的造模方法、模型特点等,旨在为本病基础研究中模型工具的选择提供参考。
- 脂肪性肝纤维化 /
- 模型,动物 /
- 小鼠
Abstract:
At present, nonalcoholic fatty liver fibrosis is one of the highlights of the research on nonalcoholic fatty liver disease (NAFLD) , and there is an urgent need for exploring its pathogenesis and treatment drugs in clinical practice. Animal model is an important tool for basic research, and the mouse model becomes the most widely used animal model of nonalcoholic fatty liver fibrosis because of susceptibility, low costs, and genomes highly homologous to those of the human being. This article reviews the methods for establishing a mouse model of nonalcoholic fatty liver fibrosis, including nutritional factor, gene knockout or mutation, and induction with various factors, as well as the features of these models, in order to provide a reference for the selection of model tools in the basic research on this disease.
- non-alcoholic fatty liver fibrosis /
- animal models /
- mice

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