儿童肝移植免疫耐受相关进展

王凯; 高伟

doi:10.3969/j.issn.1001-5256.2019.11.005

儿童肝移植免疫耐受相关进展

DOI: 10.3969/j.issn.1001-5256.2019.11.005

王凯,
高伟

天津市第一中心医院儿童器官移植科

基金项目:

天津市卫计委攻关项目(16KG107)；天津市自然科学基金项目(17JCYBJC27500)；

详细信息

中图分类号: R726.5
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出版历程
- 收稿日期: 2019-10-07
- 出版日期: 2019-11-20

Research advances in immune tolerance in children receiving liver transplantation

Wang Kai,
Gao Wei

Department of Pediatric Organ Transplantation,Tianjin First Central Hospital

Research funding:

摘要

摘要: 相比于成人受者,儿童肝移植受者对于免疫耐受的需求更为迫切,成功实现免疫耐受的概率更高。但目前,在临床上缺乏有效的实验方案、免疫监测手段以及对长期停用免疫抑制剂后移植物组织学的评估,导致免疫耐受长期停留于理论阶段,尚未在临床上有效、广泛开展。通过对儿童肝移植术后免疫耐受在近年来的进展与面临的困难进行简要综述,以期对临床操控性免疫耐受提供一定的帮助。
- 肝移植 /
- 免疫耐受 /
- 儿童
Abstract: Compared with adult recipients,pediatric liver transplantation recipients have urgent needs for immune tolerance,with a higher probability of successful realization of immune tolerance. However at present,there is still a lack of effective experimental regimens,immune monitoring methods,and graft histological evaluation after long-term discontinuation of immunosuppressive agents in clinical practice,which results in the fact that immune tolerance stays in the theoretic stage and is not effectively implemented in clinical practice. This article reviews the advances and difficulties in immune tolerance in pediatric liver transplantation recipients in recent years,in order to provide help for operational immune tolerance in future.
- liver transplantation /
- immune tolerance /
- child

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参考文献(65)

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