Histological reversal after treatment of drug-induced cirrhosis with Yiqi Liangxue TCM combined with Fuzheng Huayu Capsule: A case report
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摘要: <正>药物性肝损伤(DILI)又称药物性肝病,是指由药物本身或其代谢产物而引起的肝脏损害。传统中药(Traditional Chinese medicine,TCM)也是造成DILI的重要原因。但也有很多研究证明,传统中医药在改善患者的症状、体征及肝功能、纤维化的逆转等方面具有明显优势。现报道本院运用中药治疗药物性肝硬化1例,并对其病理特点作简要分析。
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Key words:
- drugs,Chinese herbal /
- drug-induced liver injury /
- liver cirrhosis /
- histology
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[1] FIORE M,LEONE S,MARAOLO AE,et al. Liver illness and psoriatic patients[J]. Biomed Res Int,2018,6(3140983):12. [2] CARNEIRO SC,CASSIA FF,LAMY F,et al. Methotrexate and liver function:A study of 13 psoriasis cases treated with different cumulative dosages[J]. J Eur Acad Dermatol Venereol,2008,22(1):25-29. [3] FINET A,VIGUIER M,CHAZOUILLERES O,et al. Liver test abnormalities in patients admitted for severe psoriasis:Prevalence and associated risk factors[J]. J Eur Acad Dermatol Venereol,2016,30(10):1742-1748. [4] MIELE L,VALLONE S,CEFALO C,et al. Prevalence,characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis[J]. J Hepatol,2009,51(4):778-786. [5] KHAN N,ABBAS AM,WHANG N,et al. Incidence of liver toxicity in inflammatory bowel disease patients treated with methotrexate:A meta-analysis of clinical trials[J]. Inflamm Bowel Dis,2012,18(2):359-367. [6] SAITHANYAMURTHI H,FAUST AJ. Drug-Induced liver disease:Clinical course[J]. Clin Liver Dis,2017,21(1):21-34. [7] FRIEDMAN S,BANSAL M. Reversal of hepatic fibrosis-fact or fantasy[J]. Hepatolology,2006,43(2):s82-s88. [8] Chinese Association of lntegrative Medicine,Liver Disease Committee. Guideline for the diagnosis and treatment of liver fibrosis with integrative medicine[J]. Chin J Integr Tradit West Med Liver Dis,2006,16(5):316-320.(in Chinese)中国中西医结合学会肝病专业委员会.肝纤维化中西医结合诊疗指南[J].中西医结合肝病杂志,2006,16(5):316-320. [9] LIU CH,LIU P,HU YY,et al. Progress of clinical and basic research on liver fibrosis with Traditional Chinese Medicine[J]. World Sci Technol Modern Tradit Chin Med,2017,9(2):112-118.(in Chinese)刘成海,刘平,胡义杨,等.中医药抗肝纤维化临床与基础研究进展[J].世界科学技术-中医药现代化,2017,9(2):112-118. [10] ZHU Y,CHENG JD,WANG LF,et al. Research progress of traditional Chinese medicine in the treatmeat of drug-induced liver injury[J]. Chin J Integr Tradit West Med Liver Dis,2014,24(4):254-256.(in Chinese)朱云,成佳黛,王立福,等.中医药治疗药物性肝损伤的研究概况[J].中西医结合肝病杂志,2014,24(4):254-256. [11] CHANG H,GUO K,MENG HY,et al. Advances in mechanistic studies on anti-liver fibrosis of active components of chinese medicine by targeting hepatic stellate cells[J]. Modern Chin Med,2017,19(1):148-153.(in Chinese)常虹,郭凯,孟洪宇,等.中药有效成分作用于肝星状细胞抗肝纤维化分子机制研究进展[J].中国现代中药,2017,19(1):148-153. [12] ZHAO ZM,LIU CH. The main mechanism and the substantial basis of FZHY recipe in the treatment of hepatic ifbrosis[J].Shanghai Med Pharm J,2016,37(13):13-16.(in Chinese)赵志敏,刘成海.扶正化瘀方抗肝纤维化的主要作用机制与效应物质[J].上海医药,2016,37(13):13-16.
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