肝细胞癌的靶向治疗

黄燊; 杨成雷; 张志明

doi:10.3969/j.issn.1001-5256.2019.11.041

肝细胞癌的靶向治疗

DOI: 10.3969/j.issn.1001-5256.2019.11.041

广西医科大学附属肿瘤医院肝胆外科

基金项目:

广西教育厅中青年教师基础能力提升项目(KY2016YB085)；广西医疗卫生适宜技术研究与开发项目(卫生厅S201516)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2019-07-05
- 出版日期: 2019-11-20

Research advances in targeted therapy for hepatocellular carcinoma

Department of Hepatobiliary Surgery,The Affiliated Tumor Hospital of Guangxi Medical University

Research funding:

摘要

摘要: 肝细胞癌是常见的恶性肿瘤之一,由于起病隐匿,预后差,缺乏特异性,多数患者确诊时已到了晚期。传统的治疗手段,如手术切除、肝移植、放疗、化疗等治疗作用有限,未能使患者明显受益。近年来,随着科技和医疗水平的整体进步,靶向治疗药物由于在肝细胞癌的治疗方面取得的突破性进展而逐渐进入人们的视野,为晚期肝癌患者带来了新的希望。由于靶向药物有较好的分子选择性,能针对性的杀伤肿瘤细胞,尽可能的保护正常组织而受到广泛关注。现就肝细胞癌的靶向治疗进展作一综述。
- 癌,肝细胞 /
- 分子靶向治疗 /
- 治疗学
Abstract: Hepatocellular carcinoma( HCC) is one of the most common malignant tumors. Due to the insidious onset,poor prognosis,and lack of specificity of HCC,most patients have reached the advanced stage at the time of diagnosis. Conventional treatment methods,such as surgical resection,liver transplantation,radiotherapy,and chemotherapy,have limited therapeutic effects and fail to bring significant benefits to patients. With the improvement of science and technology and medical level in recent years,targeted therapy drugs have gradually entered people's vision due to the breakthroughs in the treatment of HCC and thus bring new hope to patients with advanced HCC. Targeted drugs have attracted wide attention due to good molecular selectivity,targeted killing of tumor cells,and protection of normal tissue. This article reviews the research advances in targeted therapy for HCC.
- carcinoma,hepatocellular /
- molecular targeted therapy /
- therapeutics

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参考文献(36)

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