肝细胞癌微血管侵犯相关危险因素

白雪; 马作红; 郝志强; 傅熙博; 焦奥; 尚海; 华向东

doi:10.3969/j.issn.1001-5256.2019.11.042

肝细胞癌微血管侵犯相关危险因素

DOI: 10.3969/j.issn.1001-5256.2019.11.042

辽宁省肿瘤医院肝胆胰外科

基金项目:

辽宁省科学技术计划项目任务合同书(20180550548)；

详细信息

中图分类号: R735.7
计量
- 文章访问数: 1078
- HTML全文浏览量: 48
- PDF下载量: 246
- 被引次数: 0
出版历程
- 收稿日期: 2019-07-03
- 出版日期: 2019-11-20

Research advances in the risk factors for microvascular invasion in hepatocellular carcinoma

Department of Hepatopancreatobiliary Surgery,Liaoning Cancer Hospital

Research funding:

摘要

摘要: 肝癌是世界上常见的恶性肿瘤之一,我国是目前肝癌发病率最高的国家。肝癌起病隐匿,患者早期常常无明显症状,然而疾病进展十分迅速,大多数患者确诊时已经发展为肿瘤晚期,且约10%的患者初次病理诊断即伴有微血管侵犯。尽管目前肝癌的治疗手段在不断的提升和进展,但患者术后复发率并没有显著下降,多项研究支持微血管侵犯是与肝癌复发相关的独立危险因素之一,病理诊断伴有微血管侵犯的患者往往提示预后不佳。然而目前临床尚缺乏术前对于微血管侵犯的评判方法,通过对关于微血管侵犯近3～5年的研究进行分析与整合,望更全面深入的了解与微血管侵犯相关的研究进展。
- 癌,肝细胞 /
- 微血管侵犯 /
- 危险因素
Abstract: Liver cancer is one of the most common malignant tumors in the world,and at present,China has the highest incidence rate of liver cancer. Liver cancer has an insidious onset,and patients often have no obvious symptoms in the early stage; however,due to the rapid progression of this disease,most patients have developed advanced tumors at the time of diagnosis,and about 10% of patients have microvascular invasion( MVI) at initial pathological diagnosis. Although continuous improvement and progress have been made in the treatment methods for liver cancer,there is no significant reduction in postoperative recurrence rate. Many studies support that MVI is one of the independent risk factors for liver cancer recurrence,and patients with MVI determined by pathological diagnosis often have poor prognosis. However,there is still a lack of preoperative evaluation methods for MVI. This article analyzes and integrates the studies on MVI in the past 3 to5 years,in order to provide a comprehensive understanding of the research advances in MVI.
- carcinoma,hepatocellular /
- microvascularinvasion /
- risk factors

HTML全文

参考文献(43)

[1] DHIR M,MELIN AA,DOUAIHER J,et al. A review and update of treatment options and controversies in the management of hepatocellular carcinoma[J]. Ann Surg,2016,263(6):1112-1125.

[2] SUN ZD,CHENG LM,PING P,et al. Analysis of the risk factors for prognosis of surgical treatment patients with primary liver cancer[J]. J Clin Exp Med,2017,16(12):1204-1207.(in Chinese)孙志德，程利民，平萍，等．影响原发性肝癌患者手术治疗预后的危险因素分析[J]．临床和实验医学杂志，2017,16(12):1204-1207.

[3] WANG H,WU MC,CONG WM. Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis[J].Hepatol Res,2019,49(3):344-354.

[4] RODRIGUEZ-PERALVAREZ M,LUONG TV,ANDREANA L,et al. A systematic review of microvascular invasion in hepatocellular carcinoma:Diagnostic and prognostic variability[J].Ann Surg Oncol,2013,20(1):325-339.

[5] HONG YM,CHO M,YOON KT,et al. Risk factors of early recurrence after curative hepatectomy in hepatocellular carcinoma[J]. Tumor Biol,2017,39(10):1010428317720863.

[6] JIN Y,LI JT. Earch progress in related clinical factors and molecular biomarkers for microvascular invasion in hepatocellular carcinoma[J]. J Clin Hepatol,2013,29(7):550-553.(in Chinese)金赟，李江涛．肝癌细胞侵犯微血管的临床相关因素及分子标志物的研究进展[J]．临床肝胆病杂志，2013,29(7):550-553.

[7] WANG LL,LI JF,DOU Y,et al. Value of magnetic resonance functional imaging in evaluating microvascular invasion of hepatocellular carcinoma[J]. J Clin Hepatol,2018,34(12):2681-2684.(in Chinese)王莉莉，李俊峰，窦郁，等．MR功能成像对肝细胞癌微血管侵犯的评估价值[J]．临床肝胆病杂志，2018,34(12):2681-2684.

[8] PAWLIK TM,DELMAN KA,VAUTHEY JN,et al. Tumor size predicts vascular invasion and histologic grade:Implications for selection of surgical treatment for hepatocellular carcinoma[J]. Liver Transpl,2005,11(9):1086-1092.

[9] ZHANG W,LIU L,WANG P,et al. Preoperative computed tomography and serum alpha-fetoprotein to predict microvascular invasion in hepatocellular carcinoma[J]. Medicine(Baltimore),2018,97(27):e11402.

[10] ESNAOLA NF,LAUWERS GY,MIRZA NQ,et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation[J].J Gastrointest Surg,2002,6(2):224-232.

[11] YE JZ,CHEN JZ,LI ZH,et al. Efficacy of postoperative adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma patients with microvascular invasion[J]. World J Gastroenterol,2017,23(41):7415-7424.

[12] RENZULLI M,BROCCHI S,CUCCHETTI A,et al. Can current preoperative imaging be used to detect microvascular invasion of hepatocellular carcinoma?[J]. Radiology,2016,279(2):432-442.

[13] LEE S,KIM SH,LEE JE,et al. Preoperative gadoxetic acidenhanced MRI for predicting microvascular invasion in patients with single hepatocellular carcinoma[J]. J Hepatol,2017,67(3):526-534.

[14] AHN SY,LEE JM,JOO I,et al. Prediction of microvascular invasion of hepatocellular carcinoma using gadoxetic acid-enhanced MR and(18)F-FDG PET/CT[J]. Abdom Imaging,2015,40(4):843-851.

[15] RYU T,TAKAMI Y,WADA Y,et al. A clinical scoring system for predicting microvascular invasion in patients with hepatocellular carcinoma within the milan criteria[J]. J Gastrointest Surg,2019,23(4):779-787.

[16] YAMASHITA YI,IMAI K,YUSA T,et al. Microvascular invasion of single small hepatocellular carcinoma≤3 cm:Predictors and optimal treatments[J]. Ann Gastroenterol Surg,2018,2(3):197-203.

[17] YU Y,SONG J,ZHANG R,et al. Preoperative neutrophil-to-lymphocyte ratio and tumor-related factors to predict microvascular invasion in patients with hepatocellular carcinoma[J]. Oncotarget,2017,8(45):79722-79730.

[18] HUI AM,TAKAYAMA T,SANO K,et al. Predictive value of gross classification of hepatocellular carcinoma on recurrence and survival after hepatectomy[J]. J Hepatol,2000,33(6):975-979.

[19] HE J,SHI J,FU X,et al. The clinicopathologic and prognostic significance of gross classification on solitary hepatocellular carcinoma after hepatectomy[J]. Medicine(Baltimore),2015,94(32):e1331.

[20] NAGANO Y,SHIMADA H,TAKEDA K,et al. Predictive factors of microvascular invasion in patients with hepatocellular carcinoma larger than 5 cm[J]. World J Surg,2008,32(10):2218-2222.

[21] ZHENG J,CHAKRABORTY J,CHAPMAN WC,et al. Preoperative prediction of microvascular invasion in hepatocellular carcinoma using quantitative image analysis[J]. J Am Coll Surg,2017,225(6):778-788.

[22] CHEN ZH,ZHANG XP,WANG H,et al. Effect of microvascular invasion on the postoperative long-term prognosis of solitary small HCC:A systematic review and meta-analysis[J].HPB(Oxford),2019,21(8):935-944.

[23] ZHANG Q,ZHANG W,ZHA Y,et al. Ping long-term survival of single hepatocellular carcinoma≤2cm with microvascular invasion[J]. Cancer Res Prev Treat,2015,42(4):356-358.(in Chinese)张麒，张文，查勇，等．单发2cm以下微血管侵犯肝癌患者的预后生存分析[J]．肿瘤防治研究，2015,42(4):356-358.

[24] DU M,CHEN L,ZHAO J,et al. Microvascular invasion(MVI)is a poorer prognostic predictor for small hepatocellular carcinoma[J]. BMC Cancer,2014,14:38.

[25] HU HT,SHEN SL,WANG Z,et al. Peritumoral tissue on preoperative imaging reveals microvascular invasion in hepatocellular carcinoma:A systematic review and meta-analysis[J].Abdom Radiol(NY),2018,43(12):3324-3330.

[26] AHN SJ,KIM JH,PARK SJ,et al. Hepatocellular carcinoma:Preoperative gadoxetic acid-enhanced MR imaging can predict early recurrence after curative resection using image features and texture analysis[J]. Abdom Radiol(NY),2019,44(2):539-548.

[27] KAIBORI M,ISHIZAKI M,MATSUI K,et al. Predictors of microvascular invasion before hepatectomy for hepatocellular carcinoma[J]. J Surg Oncol,2010,102(5):462-468.

[28] KIM BK,HAN KH,PARK YN,et al. Prediction of microvascular invasion before curative resection of hepatocellular carcinoma[J]. J Surg Oncol,2008,97(3):246-252.

[29] NITTA H,ALLARD MA,SEBAGH M,et al. Prognostic value and prediction of extratumoral microvascular invasion for hepatocellular carcinoma[J]. Ann Surg Oncol,2019,26(8):2568-2576.

[30] YAMASHITA Y,TSUIJITA E,TAKEISHI K,et al. Predictors for microinvasion of small hepatocellular carcinoma≤2 cm[J].Ann Surg Oncol,2012,19(6):2027-2034.

[31] YU YQ,JIN Y,ZHOU JL,et al. Sero-biomarkers for predicting microvascular invasion in hepatocellular carcinoma before liver resection[J]. HPB,2016,18:e198.

[32] POTE N,CAUCHY F,ALBUQUERQUE M,et al. Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion[J]. J Hepatol,2015,62(4):848-854.

[33] ENOOKU K,URANBILEG B,IKEDA H,et al. Higher LPA2and LPA6 mRNA levels in hepatocellular carcinoma are associated with poorer differentiation,microvascular invasion and earlier recurrence with higher serum autotaxin levels[J].PLoS One,2016,11(9):e0161825.

[34] XIANG LY,OU HH,LIU XC,et al. Loss of tumor suppressor mi R-126 contributes to the development of hepatitis B virusrelated hepatocellular carcinoma metastasis through the upregulation of ADAM9[J]. Tumour Biol, 2017, 39(6):1010428317709128.

[35] LEI Z,LI J,WU D,et al. Nomogram for preoperative estimation of microvascular invasion risk in hepatitis B virus-related hepatocellular carcinoma within the milan criteria[J]. JAMA Surg,2016,151(4):356-363.

[36] XU L,ZHANG M,ZHENG X,et al. The circular RNA ciRS-7(Cdr1as)acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma[J]. J Cancer Res Clin Oncol,2017,143(1):17-27.

[37] ZHAO X,LIU Y,YU S. Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1and serves as a prognostic biomarker[J]. Biochim Biophys Acta Mol Basis Dis,2017,1863(7):1805-1816.

[38] FU L,CHEN Q,YAO T,et al. Hsa_circ_0005986 inhibits carcinogenesis by acting as a mi R-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma[J]. Oncotarget,2017,8(27):43878-43888.

[39] LIU J,NI W,QU L,et al. Decreased expression of EHD2 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma[J]. Dig Dis Sci,2016,61(9):2554-2567.

[40] YU SL,WU JC,LIU PF,et al. Up-regulation of RNF187 induces hepatocellular carcinoma cell epithelial to mesenchymal transitions[J]. Oncotarget,2017,8(60):101876-101886.

[41] SUN L,LI PB,YAO YF,et al. Proteinase-activated receptor2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma[J]. World J Gastroenterol,2018,24(10):1120-1133.

[42] GE YS,LIU D,JIA WD,et al. Kindlin-2:A novel prognostic biomarker for patients with hepatocellular carcinoma[J].Pathol Res Pract,2015,211(3):198-202.

[43] HAN J,LI ZL,XING H,et al. The impact of resection margin and microvascular invasion on long-term prognosis after curative resection of hepatocellular carcinoma:A multi-institutional study[J]. HPB(Oxford),2019,21(8):962-971.

施引文献

资源附件(0)

访问统计