Advances in the clinical research on autoimmune liver disease with Sjgren's syndrome
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摘要: 自身免疫性肝病是一组因自身免疫系统紊乱造成的肝脏疾病,其中部分患者表现为口干、眼干症状。临床中常见自身免疫性肝病患者合并干燥综合征,就自身免疫性肝病合并干燥综合征的临床表现、病理特点、诊治要点及预后等方面的研究进展进行总结。自身免疫性肝病与干燥综合征可能存在共同的发病机制,制订并选择对二者均有利的治疗方案,是今后主要的研究方向。Abstract: Autoimmune liver disease is a group of liver diseases caused by the disorder of the autoimmune system,and some patients may have the symptoms of dry mouth and dry eyes. Patients with autoimmune liver disease and Sjgren's syndrome are commonly seen in clinical practice. This article summarizes the research advances in the clinical manifestation,pathological features,key diagnosis/treatment points,and prognosis of autoimmune liver disease with Sjgren's syndrome.
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Key words:
- hepatitis,autoimmune /
- Sjgren's syndrome /
- diagnosis /
- therapeutics
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[1] van GERVEN NM,VERWER BJ,WITTE BI,et al. Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands[J]. Scand J Gastroenterol,2014,49(10):1245-1254. [2] KARP JK,AKPEK EK,ANDERS RA. Autoimmune hepatitis in patients with primary Sjgren’s syndrome:A series of twohundred and two patients[J]. Int J Clin Exp Pathol,2010,3(6):582-586. [3] RAMOS-CASALS M,SANCHEZTAPIAS JM,PARES A,et al.Characterization and differentiation of autoimmune versus viral liver involvement in patients with Sjgren’s syndrome[J]. J Rheumatol,2006,33(8):1593-1599. [4] MURATORI P,FABBRI A,LALANNE C,et al. Autoimmune liver disease and concomitant extrahepatic autoimmune disease[J]. Eur J Gastroenterol Hepatol,2015,27(10):1175. [5] GERSHWIN ME,SELMI C,WORMAN HJ,et al. Risk factors and comorbidities in primary biliary cirrhosis:A controlled interview-based study of 1032 patients[J]. Hepatology,2005,42(5):1194-1202. [6] WATT FE,JAMES OF,JONES DE. Patterns of autoimmunity in primary biliary cirrhosis patients and their families:A population-based cohort study[J]. QJM,2004,97(7):397-406. [7] INVERNIZZI P,SELMI C,MACKAY IR,et al. From bases to basis:Linking genetics to causation in primary biliary cirrhosis[J]. Clin Gastroenterol Hepatol,2005,3(5):401-410. [8] SELMI C,MAYO MJ,BACH N,et al. Primary biliary cirrhosis in monozygotic and dizygotic twins:Genetics,epigenetics,and environment[J]. Gastroenterology,2004,127(2):485-492. [9] INVERNIZZI P,MIOZZO M,BATTEZZATI PM,et al. Frequency of monosomy X in women with primary biliary cirrhosis[J].Lancet,2004,363(9408):533-535. [10] Ll EO A,OERTELT-PRIGIONE S,BIANCHI I,et al. Y chromosome loss in male patients with primary biliary cirrhosis[J].J Autoimmun,2013,41:87-91. [11] MELLS GF,KASER A,KARLSEN TH. Novel insights into autoimmune liver diseases provided by genome-wide association studies[J]. J Autoimmun,2013,46:41-54. [12] LI Y,ZHANG K,CHEN H,et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren’s syndrome at 7q11. 23[J]. Nat Genet,2013,45(11):1361. [13] FOGEL R,COMERFORD M,CHILUKURI P,et al. Extrahepatic autoimmune diseases are prevalent in autoimmune hepatitis patients and their first-degree relatives:Survey study[J]. Interact J Med Res,2018,7:e18. [14] MARTINEZ A,VARADE A,MARQUEZ A,et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases[J]. Arthritis rheum,2008,58(9):2598-2602. [15] MATSUMOTO T,MORIZANE T,AOKI Y,et al. Autoimmune hepatitis in primary Sjogren’s syndrome:Pathological study of the livers and labial salivary glands in 17 patients with primary Sjogren’s syndrome[J]. Pathol Int,2010,55(2):70-76. [16] FOX RI,PEARSON G,VAUGHAN JH. Detection of EpsteinBarr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjogren’s syndrome[J]. J Immunol,1986,137(10):3162-3168. [17] BOGDANOS DP,BAUM H,GRASSO A,et al. Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis[J]. J Hepatol,2004,40:31-39. [18] ZHANG J,ZHANG W,LEUNG PS,et al. Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis[J].Hepatology,2014,60:1708-1716. [19] BAE HR,HODGE DL,YANG GX,et al. The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity[J]. Hepatology,2018,67:1408-1419. [20] SCHWINGE D,SCHRAMM C. Sex-related factors in autoimmune liver diseases[J]. Semin Immunopathol,2019,41:165-175. [21] SANDHU V,JAWAD AS. Hepatic manifestations of autoimmune rheumatic diseases[J]. Ann of Gastroenterol,2007,18(3):123-129. [22] TSUNEYAMA K,CHA S,NAKANUMA Y,et al. Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjogren’s syndrome[J]. Hepatology,2010,20(4):893-898. [23] MANOUSSAKIS MN,MOUTSOPOULOS HM. Sjgren’s syndrome[J]. Autoimmune Epithelitis Clin Rev Allergy Immunol,2000,14(1):73-95. [24] DRENTH JPH. EASL clinical practice guidelines:Autoimmune hepatitis[J]. J Hepatol,2015,63(4):971-1004. [25] HIRSCHFIELD GM,BEUERS U,CORPECHOT C,et al. EASL clinical practice guidelines:The diagnosis and management of patients with primary biliary cholangitis[J]. J Hepatol,2017,67:145-172. [26] CHAPMAN MH,THORBURN D,HIRSCHFIELD GM,et al.British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis[J]. Gut,2019,68:1356-1378. [27] HU ZC,FAN XL,SHEN Y,et al. Current status and recent progress of second-line drugs for autoimmune hepatitis[J].J Clin Hepatol,2018,34(5):214-217.(in Chinese)胡智超,凡小丽,沈怡,等.自身免疫性肝炎的二线药物治疗现状[J].临床肝胆病杂志,2018,34(5):214-217. [28] YUAN XY,SUN LY. Clinical analysis of Sjogren’s syndrome with autoimmune hepatitis[J]. Jiangsu Med J,2005,31(4):310.(in Chinese)袁小燕,孙凌云.干燥综合征合并自身免疫性肝炎的临床分析[J].江苏医药,2005,31(4):310. [29] SHI YY,SHI XH,FEI YY,et al. Clinical obervation of the therapeutic response of primary biliary cirrhosis[J]. Chin J Rheumatol,2011,15(2):91-96.(in Chinese)石运莹,史旭华,费允云,等.熊去氧胆酸及其联合激素和免疫抑制剂治疗原发性胆汁性肝硬化的临床观察[J].中华风湿病学杂志,2011,15(2):91-96. [30] BI XL,GUAN B,ZHU JR. Clinical effect of ursodeoxycholic acid combined with prednisolone on primary biliary cirrhosis with Sjogren syndrome[J]. J Guzhou Med Univ,2017,42(2):226-229.(in Chinese)白晓莉,管斌,朱建荣.熊去氧胆酸联合泼尼松龙治疗原发性胆汁性肝硬化合并干燥综合征[J].贵州医科大学学报,2017,42(2):226-229. [31] GAO LX,ZHANG FC,WANG L,et al. The Clinical obervation of different therapeutic strategies in combined primary biliary cirrhosis and primary Sjgren’s syndrome[J]. Chin J Intern Med,2012,51(11):851-854.(in Chinese)高丽霞,张奉春,王立,等.不同方案治疗原发性胆汁性肝硬化合并干燥综合征的临床研究[J].中华内科杂志,2012,51(11):851-854. [32] GRIGORIAN AY,MARDINI HE,CORPECHOT C,et al. Fenofibrate is effective adjunctive therapy in the treatment of primary biliary cirrhosis:A meta-analysis[J]. Clin Res Hepatol Gastroenterol,2015,39(3):296-306. [33] WONG GW,YEONG T,LAWRENCE D,et al. Concurrent extrahepatic autoimmunity in autoimmune hepatitis:Implications for diagnosis,clinical course and long term outcome[J]. Liver Int,2016,37(3):449-457. [34] WANG L,ZHANG FC,CHEN H,et al. Connective tissue diseases in primary biliary cirrhosis:A population-based cohort study[J]. World J Gastroenterol,2013,19(31):5131-5137. [35] CHEN CT,TSENG YC,YANG CW,et al. Increased risks of spontaneous bacterial peritonitis and interstitial lung disease in primary biliary cirrhosis patients with concomitant Sjgren’s syndrome[J]. Medicine,2016,95:e2537.
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