肝内胆管癌的肝移植治疗——争议与前景

张洪涛; 陶开山

doi:10.3969/j.issn.1001-5256.2019.12.006

肝内胆管癌的肝移植治疗——争议与前景

DOI: 10.3969/j.issn.1001-5256.2019.12.006

空军军医大学西京医院肝胆外科

详细信息

中图分类号: R735.8
计量
- 文章访问数: 1343
- HTML全文浏览量: 45
- PDF下载量: 237
- 被引次数: 0
出版历程
- 收稿日期: 2019-11-12
- 出版日期: 2019-12-20

Liver transplantation for the treatment of intrahepatic cholangiocarcinoma: Controversies and perspectives

Department of Hepatobiliary Surgery,Xijing Hospital,Air Force Medical University

摘要

摘要: 肝移植是治疗终末期肝病的唯一有效手段,但在治疗肝内胆管癌方面却一直存在争议。肝内胆管癌恶性程度高,症状隐匿,早期缺乏特异性临床表现,一旦发现多处于进展期,失去手术切除机会,预后很差。随着肝移植治疗肝内胆管癌的研究进展,制定规范化的患者选择标准、联合新辅助治疗和辅助治疗,可能成为治疗局部晚期肝内胆管癌的一种有前途的方案。
- 胆管肿瘤 /
- 肝移植 /
- 肿瘤辅助疗法
Abstract: Liver transplantation is the only effective method for the treatment of end-stage liver disease,but there are still controversies over its application in the treatment of intrahepatic cholangiocarcinoma( ICC). ICC has a high degree of malignancy,occult symptoms,and a lack of specific clinical manifestations in the early stage. Most patients are in the advanced stage at the time of diagnosis and lose the opportunity for surgical resection,and thus they tend to have poor prognosis. With the research advances in liver transplantation for the treatment of ICC,development of standardized criteria for patient selection and combination with neoadjuvant therapy and adjuvant therapy may become a promising method for the treatment of locally advanced ICC.
- bile duct neoplasms /
- liver transplantation /
- neoadjuvant therapy

HTML全文

参考文献(21)

[1] GUPTA A,DIXON E. Epidemiology and risk factors:Intrahepatic cholangiocarcinoma[J]. Hepatobiliary Surg Nutr,2017,6(2):101-104.

[2] SHAIB Y,EL-SERAG HB. The epidemiology of cholangiocarcinoma[J]. Semin Liver Dis,2004,24(2):115-125.

[3] WEBER SM,RIBERO D,O’REILLY EM,et al. Intrahepatic Cholangiocarcinoma:Expert consensus statement[J]. HPB,2015,17(8):669-680.

[4] ROBLES R,FIGUERAS J,TURRIN VS,et al. Spanish experience in liver transplantation for hilar and peripheral cholangiocarcinoma[J]. Ann Surg,2004,239(2):265-271.

[5] SOTIROPOULOS GC,KAISER GM,LANG H,et al. Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma:A single-center experience[J]. Transplant Proc,2008,40(9):3194-3195.

[6] SAPISOCHIN G,FIDELMAN N,ROBERTS JP,et al. Mixed hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma in patients undergoing transplantation for hepatocellular carcinoma[J]. Liver Transpl,2011,17(8):934-942.

[7] PANJALA C,NGUYEN JH,AL-HAJJAJ AN,et al. Impact of neoadjuvant chemoradiation on the tumor burden before liver transplantation for unresectable cholangiocarcinoma[J]. Liver Transpl,2012,18(5):594-601.

[8] RAZUMILAVA N,GORES GJ. Cholangiocarcinoma[J]. Lancet,2014,383(9935):2168-2179.

[9] BRIDGEWATER J,GALLE PR,KHAN SA,et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma[J]. J Hepatol,2014,60(6):1268-1289.

[10] SAPISOCHIN G,de LOPE CR,GASTACA M,et al. Intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma in patients undergoing liver transplantation:A Spanish matched cohort multicenter study[J]. Ann Surg,2014,259(5):944-952.

[11] SAPISOCHIN G,RODRGUEZ de LOPE C,GASTACA M,et al．“Very early”intrahepatic cholangiocarcinoma in cirrhotic patients:Should liver transplantation be reconsidered in these patients?[J]. Am J Transplant,2014,14(3):660-667.

[12] SAPISOCHIN G,FACCIUTO M,RUBBIA-BRANDT L,et al.Liver transplantation for"very early"intrahepatic cholangiocarcinoma:International retrospective study supporting a prospective assessment[J]. Hepatology,2016,64(4):1178-1188.

[13] HONG JC,JONES CM,DUFFY JP,et al. Comparative analysis of resection and liver transplantation for intrahepatic and hilar cholangiocarcinoma:A 24-year experience in a single center[J]. Arch Surg,2011,146:683-689.

[14] HONG JC,KALDAS FM,KOSITAMONGKOL P,et al. Predictive index for long-term survival after retransplantation of the liver in adult recipients:Analysis of a 26-year experience in a single center[J]. Ann Surg,2011,254(3):444-448; discussion 448-449.

[15] FACCIUTO ME,SINGH MK,LUBEZKY N,et al. Tumors with intrahepatic bile duct differentiation in cirrhosis:Implications on outcomes after liver transplantation[J]. Transplantation,2015,99(1):151-157.

[16] NJEI B,SCHILSKY ML,DITAH IC,et al. Should liver transplantation be reconsidered in patients with intrahepatic cholangiocarcinoma? A systematic review and meta-regression analysis of epidemiologic evidence[J]. Gastroenterology,2015,148(4):S-1036.

[17] GOLDSTEIN RM,STONE M,TILLERY GW,et al. Is liver transplantation indicated for cholangiocarcinoma?[J]. Am J Surg,1993,166(6):768-771; discussion 771-772.

[18] CARRAFIELLO G,LAGAND,COTTA E,et al. Radiofrequency ablation of intrahepatic cholangiocarcinoma:Preliminary experience[J]. Cardiovasc Intervent Radiol,2010,33(4):835-839.

[19] TSE RV,HAWKINS M,LOCKWOOD G,et al. Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma[J]. J Clin Oncol,2008,26(4):657-664.

[20] KOPEK N,HOLT MI,HANSEN AT,et al. Stereotactic body radiotherapy for unresectable cholangiocarcinoma[J]. Radiother Oncol,2010,94(1):47-52.

[21] ZHOU L,DU GS,ZHU ZD,et al. Report on the efficacy of triple therapy in the prevention of recurrence after liver transplantation for advanced intrahepatic cholangiocarcinoma[J/CD].Chin J Oper Proc Gen Surg:Electronic Version,2014,8(1):39-41.(in Chinese)周林，杜国盛，朱志东，等．预防晚期肝内胆管细胞癌肝移植术后复发的三联疗法疗效报道[J/CD]．中华普外科手术学杂志:电子版，2014,8(1):39-41.

施引文献

资源附件(0)

访问统计