HBV诱导的髓源性抑制细胞亚群及其在慢性HBV感染中的作用

邬志惠; 杨苗苗; 涂正坤

doi:10.3969/j.issn.1001-5256.2019.12.030

HBV诱导的髓源性抑制细胞亚群及其在慢性HBV感染中的作用

DOI: 10.3969/j.issn.1001-5256.2019.12.030

吉林大学第一医院转化医学研究院

基金项目:

国家自然科学基金(81373143,81571535)；

详细信息

中图分类号: R512.62
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- 文章访问数: 841
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- 被引次数: 0
出版历程
- 收稿日期: 2019-09-02
- 出版日期: 2019-12-20

Role of hepatitis B virus-induced myeloid-derived suppressor cell subsets in chronic HBV infection

Research Institute of Translational Medicine,The First Hospital of Jilin University

Research funding:

摘要

摘要: HBV是一种嗜肝性DNA病毒,HBV感染不会引起直接的肝细胞病变,宿主免疫应答决定了病毒能否被清除,同时也是导致HBV相关肝脏疾病的主要原因。髓源性抑制细胞(MDSC)是一群起源于骨髓的非淋巴免疫抑制性细胞,多种病理条件下调节固有和获得性免疫应答。研究发现慢性乙型肝炎患者外周血中MDSC明显高于健康人群,主要介绍了HBV诱导的MDSC亚群在HBV持续感染和肝脏病理学机制中的作用。
- 乙型肝炎病毒 /
- 髓源性抑制细胞 /
- 乙型肝炎,慢性 /
- 免疫,细胞 /
- T淋巴细胞
Abstract: Hepatitis B virus( HBV) is a member of hepadnavirus,and HBV infection may not cause direct hepatocyte lesions. Host immune response determines whether the virus can be eliminated and is a major cause of HBV-related liver diseases. Myeloid-derived suppressor cells( MDSCs) are a group of non-lymphoid immune suppressor cells originating from bone marrow and can regulate innate and adaptive immune responses under different pathological conditions. Studies have shown that chronic hepatitis B patients have a significantly higher number of MDSCs in peripheral blood than the healthy population. This article introduces the role of HBV-induced MDSC subsets in persistent HBV infection and liver pathological mechanism.
- hepatitis B virus /
- myeloid-derived suppressor cells /
- hepatitis B,chronic /
- immunity,cellular /
- T-lymphocytes

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参考文献(54)

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