钠-葡萄糖协同转运蛋白2抑制剂治疗2型糖尿病合并非酒精性脂肪肝病的研究进展

薛苗苗; 李雪萍; 李亚; 闫娜娜; 许刚柱; 宋梅

doi:10.3969/j.issn.1001-5256.2019.12.037

钠-葡萄糖协同转运蛋白2抑制剂治疗2型糖尿病合并非酒精性脂肪肝病的研究进展

DOI: 10.3969/j.issn.1001-5256.2019.12.037

1. 西安医学院临床医学院
2. 西安医学院第一附属医院内分泌科
3. 西安医学院第一附属医院神经外科
4. 西安医学院护理学院

基金项目:

陕西省软科学研究计划-重点项目(2018KRM170)；西安医学院护理省级重点学科建设项目(16hlxk03)；

详细信息

中图分类号: R575.5;R587.1
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出版历程
- 收稿日期: 2019-07-22
- 出版日期: 2019-12-20

Research advances in sodium-glucose co-transporter 2 inhibitor in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease

Clinical Medical College,Xi'an Medical University

Research funding:

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）是2型糖尿病（T2DM）的常见并发症,可进展为肝硬化甚至相关性肝癌。然而目前尚缺乏有效的药物治疗。钠-葡萄糖协同转运蛋白2抑制剂（SGLT-2i）作为一种新批准的口服降血糖药,可有效降低血糖。同时,SGLT-2i尚可从改善脂质堆积,改善胰岛素抵抗,抗炎、抗氧化应激,延缓肝纤维化程度,延缓肝细胞癌进展等方面改善NAFLD。同时,可在减轻高糖毒性、减轻体质量、改善肝功能障碍、降低血尿酸等方面对NAFLD起到预防作用。从T2DM合并NAFLD的现状、SGLT-2i的作用机制、SGLT-2i对T2DM合并NAFLD的预防及安全性方面进行了阐述。
- 糖尿病,2型 /
- 非酒精性脂肪性肝病 /
- 钠-葡萄糖协同转运蛋白2抑制剂
Abstract: Nonalcoholic fatty liver disease( NAFLD) is a common complication of type 2 diabetes mellitus( T2 DM) and can progress to liver cirrhosis and even hepatocellular carcinoma,but there are still no effective pharmacotherapies for NAFLD at present. Sodium-glucose co-transporter 2 inhibitor( SGLT-2 i) is a newly approved oral hypoglycemic agent and can effectively reduce blood glucose. Meanwhile,SGLT-2 i can improve NAFLD by improving lipid accumulation and insulin resistance,exerting anti-inflammatory and anti-oxidative stress effects,reducing liver fibrosis degree,and delaying the progression to hepatocellular carcinoma. SGLT-2 i also helps with the prevention of NAFLD by reducing the toxicity of high glucose,body weight,and blood uric acid and improving liver dysfunction. This article reviews the current status of T2 DM with NAFLD,the mechanism of action of SGLT-2 i,the effect of SGLT-2 i in preventing T2 DM with NAFLD,and the safety of SGLT-2 i.
- diabetes mellitus,type 2 /
- nonalcoholic fatty liver disease /
- sodium-glucose co-transporter-2 inhibitor

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参考文献(54)

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