酒精性肝病进展中的抗氧化剂

陈海震; 黄晶

doi:10.3969/j.issn.1001-5256.2019.12.038

酒精性肝病进展中的抗氧化剂

DOI: 10.3969/j.issn.1001-5256.2019.12.038

陈海震,
黄晶

吉林大学第一医院检验科

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-07-24
- 出版日期: 2019-12-20

Research advances in antioxidants in the progression of alcoholic liver disease

Department of Clinical Laboratory,The First Hospital of Jilin University

摘要

摘要: 酒精性肝病(ALD)是长期大量饮酒所导致的一系列慢性非传染性肝脏疾病。乙醇代谢过程中会产生活性氧(ROS),若ROS无法被彻底清除,所造成的氧化应激导致Kupffer细胞炎症反应和脂质过氧化,加速酒精性肝炎和纤维化的进展。人体可以表达多种酶或抗氧化物质清除ROS及其副产物以抵抗氧化应激,主要对ALD中参与抗氧化的几种酶或抗氧化物质进行了综述。
- 肝疾病,酒精性 /
- 抗氧化剂 /
- 活性氧
Abstract: Alcoholic liver disease( ALD) is a series of chronic non-infectious liver diseases caused by long-term heavy alcohol consumption. Reactive oxygen species( ROS) is produced during alcohol metabolism,and if it is not eliminated completely,it may cause oxidative stress,which will further lead to inflammatory response of Kupffer cells and lipid peroxidation and thus accelerate the progression of alcoholic hepatitis and fibrosis. The human body can generate a variety of enzymes or antioxidants to eliminate ROS and its by-products and resist oxidative stress. This article reviews several enzymes or antioxidants involved in antioxidant activity in ALD.
- liver diseases,alcoholic /
- antioxidants /
- reactive oxygen species

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参考文献(39)

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