康莱特注射液联合经肝动脉化疗栓塞术治疗中晚期肝癌效果的Meta分析

孙冬雪; 杨柱; 龙奉玺; 魏显鳗; 唐东昕

doi:10.3969/j.issn.1001-5256.2020.02.026

康莱特注射液联合经肝动脉化疗栓塞术治疗中晚期肝癌效果的Meta分析

DOI: 10.3969/j.issn.1001-5256.2020.02.026

1. 贵阳中医学院第一临床附属医院
2. 贵州省中医肿瘤传承与科技创新人才基地

基金项目:

国家自然科学基金(81673862,81460697)；中医肿瘤学研究生工作站(黔教研合JYSZ字〔2014〕018)；贵州省教育厅青年人才成长项目(黔教合KY字〔2018〕210)；研究生教育创新计划(YFYYJSCX2018-37,YFYYJSCX2018-04)；

详细信息

中图分类号: R735.7
计量
- 文章访问数: 1380
- HTML全文浏览量: 61
- PDF下载量: 211
- 被引次数: 0
出版历程
- 收稿日期: 2019-10-29
- 出版日期: 2020-02-20

Efficacy and safety of Kanglaite injection combined with transarterial chemoembolization in treatment of advanced liver cancer: A Meta-analysis

The First Clinical Affiliated Hospital of Guiyang College of Traditional Chinese Medicine

Research funding:

摘要

摘要:
目的对康莱特注射液(KLT)联合经肝动脉化疗栓塞术(TACE)治疗中晚期肝癌的有效性和安全性进行Meta分析。方法检索中国知网、万方数据库、维普数据库、中国生物医学数据库、PubMed、Cochrane Library、Embase自数据库建立至2019年10月的文献,筛选有关KLT与TACE治疗中晚期肝癌的临床研究,试验组为KLT联合TACE治疗,对照组为单独应用TACE治疗。对纳入的文献提取资料及质量评价,采用Revman5. 3软件进行Meta分析。各研究间的异质性采用χ2检验判断;用比值比(OR)和95%可信区间(95%CI)评价结局指标;采用漏斗图对发表偏倚进行评估。结果纳入16篇符合标准的文献,共1131例患者,其中试验组558例,对照组573例。与对照组相比,试验组可显著提高瘤体治疗有效率(OR=2. 85,95%CI:2. 17～3. 76,P <0. 001),提升疾病控制率(OR=2. 58,95%CI:1. 57～4. 24,P <0. 001),提高生存质量卡氏评分(OR=3. 54,95%CI:2. 48～5. 06,P <0. 001),显...
- 肝肿瘤 /
- 化学栓塞,治疗性 /
- 康莱特注射液 /
- Meta分析(主题)
Abstract:
Objective To investigate the efficacy and safety of Kanglaite injection( KLT) combined with transarterial chemoembolization( TACE) in the treatment of advanced liver cancer through a Meta-analysis. Methods CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane Library,and Embase were searched for clinical studies on KLT combined with TACE in the treatment of advanced liver cancer published up to October 2019. The patients in the experimental group were given KLT combined with TACE,while those in the control group were given TACE alone. Data extraction and quality assessment were performed for the articles included in the analysis,and RevMan 5. 3 was used for Meta-analysis. The chi-square test was used to evaluate heterogeneity between studies; odds ratio( OR) and 95% confidence interval( CI) were used to evaluate outcome measures; funnel plots were used to evaluate publication bias. Results A total of 16 articles which met the inclusion criteria were included,with a total of 1131 patients( 558 patients in the experimental group and 573 in the control group). Compared with the control group,the experimental group had significant increases in tumor response rate( OR = 2. 85,95% CI:2. 17-3. 76,P < 0. 001),disease control rate( OR = 2. 58,95% CI: 1. 57-4. 24,P < 0. 001),and Karnofsky Performance Scale score for quality of life( OR = 3. 54,95% CI: 2. 48-5. 06,P < 0. 001),as well as significant improvements in clinical symptoms( OR = 3. 71,95% CI: 1. 55-8. 89,P = 0. 003) and alpha-fetoprotein level( OR = 2. 57,95% CI: 1. 41-4. 68,P = 0. 002). In addition,the experimental group had a significantly lower incidence rate of bone marrow suppression than the control group( leukocyte reduction: OR = 0. 39,95% CI: 0. 23-0. 66,P < 0. 001; thrombocytopenia: OR = 0. 22,95% CI: 0. 12-0. 42,P < 0. 001). Conclusion In the treatment of advanced liver cancer,KLT combined with TACE results in a high response rate and good quality of life and can reduce the incidence rate of toxic and side effects including bone marrow suppression due to chemotherapy.
- liver neoplasms /
- chemoembolization,therapeutic /
- Kanglaite injection /
- Meta-analysis as topic

HTML全文

参考文献(28)

[1] FORNER A,LLOVET JM,BRUXI J,et al. Hepatocellular carcinoma[J]. Lancet,2012,379(9822):1245-1255.

[2] FERLAY J,AHIN HR,BRAYF,et al. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J]. Int J Cancer,2010,127(12):2893-2917.

[3] YUAN GQ,MO CJ,ZHANG ZC. Clinical effect of transarterial chemoembolization combined with radiofrequency ablation in treatment of primary liver cancer[J]. Clin J Med Offic,2019,47(10):1126-1127.(in Chinese)袁广庆，莫灿均，张志成．肝动脉化疗栓塞联合射频消融治疗原发性肝癌临床疗效观察[J]．临床军医杂志，2019,47(10):1126-1127.

[4] CUI HZ,GE W,CAO DD,et al. Efficacy of Apatinib Mesylate combined with hepatic artery embolization chemotherapy in the treatment of advanced primary liver cancer[J]. China Med Herald,2019,16(14):88-91.(in Chinese)崔海忠，戈伟，曹德东，等．甲磺酸阿帕替尼联合肝动脉栓塞化疗治疗中晚期原发性肝癌的效果[J]．中国医药导报，2019,16(14):88-91.

[5] European Association for the Study of the Liver,European Organisation for Research and Treatment of Cancer. EASLEORTC clinical practice guidelines:Management of hepatocellular carcinoma[J]. J Hepatol,2012,56(4):908-943.

[6] LIU HQ,CHEN SX,LI Y,et al. Clinical observation of Kang’aiinjection with TACE in 34 patients with hepatocellular carcinoma(HC)[J]. Hainan Med J,2007,18(8):19-20.(in Chinese)刘华强，陈思现，李勇，等．康艾注射液联合肝动脉化疗栓塞术治疗肝癌34例临床观察[J]．海南医学，2007,18(8):19-20.

[7] Cochrane Handbook for Systematic Reviews of Interventions Version 5. 1. 0[updated September 2011] Links Export Central Citation[EB/OL]. http://www. Cochranehandbook. org.

[8] WU JL. Clinical effect of Kanglaite injection combined with interventional chemotherapy in treatment of advanced liver cancer[J]. China’s Naturopathy,2015,23(12):60-61.(in Chinese)吴进录．康莱特注射液联合介入化疗治疗中晚期肝癌的临床观察[J]．中国民间疗法，2015,23(12):60-61.

[9] GAO XH. Clinical study of Kanglaite combined with interventional chemotherapy in the treatment of primary liver cancer[J]. World J Complex Medicine,2019,5(4):166-168.(in Chinese)高兴湖．康莱特联合介入化疗治疗原发性肝癌的临床研究[J]．世界复合医学，2019,5(4):166-168.

[10] NIU B,ZHANG Q. Clinical observation on interventional infusion of Kanglaite on massive liver cancer[J]. J Hubei Univ Chin Med,2018,20(5):26-28.(in Chinese)牛犇，张清．巨块型肝癌介入灌注康莱特治疗的临床研究[J]．湖北中医药大学学报，2018,20(5):26-28.

[11] LU DP,WANG YQ,ZHAO WL,et al. Clinical effect of Kanglaite injection combined with transarterial chemoembolization in treatment of liver cancer[J]. World Clin Med,2017,11(5):70,72.(in Chinese)路大鹏，王玉强，赵卫林，等．康莱特联合肝动脉化疗栓塞术治疗肝癌的临床研究[J]．世界临床医学，2017,11(5):70,72.

[12] HU JB,WENG J,LIU SL,et al. Clinical effect of Kanglaite injection combined with interventional chemoembolization in treatment of advanced liver cancer[J]. Shanxi Oncol Medicine,2003,11(1):48-49.(in Chinese)胡建兵，翁洁，刘颂莲，等．康莱特联合介入化疗栓塞治疗中晚期肝癌疗效观察[J]．陕西肿瘤医学，2003,11(1):48-49..

[13] ZHANG YJ,CAO JH,XU XD,et al. A clinical study on Kanglaite combined with interventional chemotherapy in the treatment of primary hepatocellular carcinoma[J]. Anti-Tumor Pharm,2017,7(1):104-108.(in Chinese)张宜江，曹继华，徐兴东，等．康莱特联合介入化疗治疗原发性肝癌的临床研究[J]．肿瘤药学，2017,7(1):104-108.

[14] QIN GY,ZHANG YY. Therapeutic effect of Kanglaite injection combined with intra-arterial chemotherapy in the treatment or mid and advanced primary liver cancer[J]. Zhejiang J Integr Tradit Chin West Med,1998,8(4):196-198.(in Chinese)钦光跃，张园园．康莱特联合介入化疗治疗中晚期肝癌疗效观察[J]．浙江中西医结合杂志，1998,8(4):196-198.

[15] LIANG SM,WANG J,SONG J. Clinical effect of Kanglaite injection combined with interventional chemoembolization in treatment of advanced liver cancer[J]. Chin J Mod Appl Pharm,2006,23(8):825-826.(in Chinese)梁素美，王静，宋健．康莱特联合介入栓塞化疗术治疗中晚期肝癌[J]．中国现代应用药学，2006,23(8):825-826.

[16] WEN FG,ZHOU LZ,HAN MJ. Clinical effect of Kanglaite injection combined with interventional treatment in treatment of liver cancer[J]. Shanxi Oncol Med,2000,8(3):187.(in Chinese)温福刚，周立中，韩铭均．康莱特联合介入治疗肝癌的临床观察[J]．陕西肿瘤医学，2000,8(3):187.

[17] WANG CH,WANG ZY. Role of Kanglaite injection in multidisciplinary multimodality therapy for primary liver cancer[J].Shanxi Oncol Medicine,2001,9(3):211-212.(in Chinese)王成红，王智瑜．康莱特在原发性肝癌多学科综合治疗中的作用[J]．陕西肿瘤医学，2001,9(3):211-212.

[18] WEI LN. Clinical observation of Kanglaite in the treatment of primary liver cancer[D]. Changchun:Jilin University,2019.(in Chinese)魏丽娜．康莱特治疗原发性肝癌的临床疗效观察[D]．长春:吉林大学，2019.

[19] FU Y. Efficacy and safety of Kanglaite injection combined with transarterial chemoembolization in treatment of primary liver cancer[J]. Healthmust-Readmagazine,2018,19:41.(in Chinese)付远．康莱特注射液联合肝动脉化疗栓塞术治疗原发性肝癌疗效及安全性观察[J]．健康必读，2018,19:41.

[20] XIE HP,LI Y,WANG FL,et al. Clinical effect of Kanglaite injection combined with transarterial chemoembolization in treatment of primary liver cancer[J]. Chin Tradit Patent Med,2018,40(12):2821-2823.(in Chinese)谢和平，李跃，王凤林，等．康莱特注射液联合肝动脉化疗栓塞术治疗原发性肝癌临床疗效[J]．中成药，2018,40(12):2821-2823.

[21] LU H,ZHOU JS,XU X,et al. Effects of transcatheter arterial chemoenboliaztion combined with Kanglaite injection on patients with advanced unresectable hepatocellular carcinoma[J]. China J Prac Med,2006,33(23):3-4.(in Chinese)陆浩，周健生，徐逊，等．康莱特注射液联合肝动脉化学栓塞治疗中晚期原发性肝癌疗效观察[J]．中国实用医刊，2006,33(23):3-4.

[22] ZHU XF. The clinical observation of the effect of Kanlaite injection combined with chemoembolization primary on middle and advanced stage liver cancer[J]. J Basic Clin Oncol,2006,19(2):132-134.(in Chinese)朱晓锋．康莱特注射液联合介入化疗栓塞治疗原发性中晚期肝癌[J]．肿瘤基础与临床，2006,19(2):132-134.

[23] LYU DZ,ZHAO CY. Clinical effect of Kanglaite injection in the adjuvant therapy for patients after intervention for liver cancer:An analysis of 38 cases[J]. New Chin Med,2004,35(7):415-416.(in Chinese)吕徳政，赵崇瑜．康莱特注射液佐治肝癌介入术后的疗效观察──附38例报告[J]．新医学，2004,35(7):415-416.

[24] LI HJ,WANG H,FANG QH,et al. Effects of Kanglaite on apoptosis and apoptotic protein procaspase-3 and caspase-9expression in hepatic carcinoma BEL-7404 cells[J]. Tumor,2010,30(9):740-743.(in Chinese)李海军，王辉，方全华，等．康莱特注射液诱导肝癌细胞凋亡及其对凋亡蛋白procaspase-3和caspase-9表达的影响[J]．肿瘤，2010,30(9):740-743.

[25] LI Y,ZHAO XM,XU HL,et al. Clinical efficacy and influence of Kanglaite combined with chemotherapy on the activity of immune cells in patients with liver cancer[J]. Prog Mod Biomed,2014,14(11):2103-2106.(in Chinese)李颖，赵兴敏，徐洪亮，等．康莱特注射液配合化疗对肝癌的治疗效果及免疫细胞活性的影响[J]．现代生物医学进展，2014,14(11):2103-2106.

[26] LONG Z,WANG B,TAO D,et al. Clinical research on alternating hyperfraction radiotherapy for massive hepatocellular carcinoma[J]. Oncol Lett,2015,10(1):523-527.

[27] RAOUL JL,PARK JW,KANG YK,et al. Using modified RECIST and alpha-fetoprotein levels to assess treatment benefit in hepatocellular carcinoma[J]. Liver Cancer,2014,3(3-4):439-450.

[28] YAN LL,NI CF,LI Z,et al. Changes in alpha-fetoprotein and des-γ-carboxy-prothrombin after transarterial chemoembolization and their value in predicting treatment outcome[J]. J Clin Hepatol,2019,35(1):109-113.(in Chinese)闫乐乐，倪才方，李智，等．肝细胞癌患者经肝动脉化疗栓塞术后AFP、脱-γ-羧基凝血酶原水平的变化及其对治疗效果的预测价值[J]．临床肝胆病杂志，2019,35(1):109-113.

施引文献

资源附件(0)

访问统计