Effect of different diet and exercise strategies on patients with nonalcoholic fatty liver disease
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摘要:
非酒精性脂肪性肝病(NAFLD)发病率逐年攀升,目前已是全球最常见的肝脏疾病之一。合理的饮食及运动是目前公认的治疗NAFLD最为关键的一步,也是管理NAFLD患者的基石,但是,由于各种客观原因,不同国家、地区、学会对NAFLD患者制定的饮食及运动方案不尽相同。对近年来不同国家、地区及不同文献所报道的干预NAFLD患者的饮食及运动方案作一综述,以期为临床医生指导NAFLD患者制订合理的饮食及运动策略提供依据。
Abstract:The incidence rate of nonalcoholic fatty liver disease( NAFLD) keeps increasing year by year,making NAFLD one of the most common liver diseases in the world. Reasonable diet and exercise are currently recognized as the most crucial step in the treatment of NAFLD and are the cornerstone of the management of NAFLD patients. However,diet and exercise regimens vary across countries,regions,and societies due to various objective reasons. This article reviews the diet and exercise regimens for NAFLD patients reported in different countries,regions,and literatures in recent years,in order to provide a basis for clinicians to guide NAFLD patients to develop reasonable diet and exercise strategies.
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Key words:
- non-alcoholic fatty liver disease /
- diet therapy /
- exercise therapy
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[1] RINELLA ME. Nonalcoholic fatty liver disease:A systematic review[J]. JAMA,2015,313(22):2263-2273. [2] DIEHL AM,DAY C. Cause,pathogenesis,and treatment of nonalcoholic steatohepatitis[J]. N Engl J Med,2017,377(21):2063-2072. [3] LOOMBA R,SANYAL AJ. The global NAFLD epidemic[J].Nat Rev Gastroenterol Hepatol,2013,10(11):686-690. [4] WONG RJ,AGUILAR M,CHEUNG R,et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States[J]. Gastroenterology,2015,148(3):547-555. [5] YOUNOSSI ZM,KOENIG AB,ABDELATIF D,et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes[J]. Hepatology,2016,64(1):73-84. [6] FARRELL GC,WONG VW,CHITTURI S. NAFLD in Asia—as common and important as in the West[J]. Nat Rev Gastroenterol Hepatol,2013,10(5):307-318. [7] LI Z,XUE J,CHEN P,et al. Prevalence of nonalcoholic fatty liver disease in mainland of China:A meta-analysis of published studies[J]. J Gastroenterol Hepatol,2014,29(1):42-51. [8] ESTES C,ANSTEE QM,ARIAS-LOSTE MT,et al. Modeling NAFLD disease burden in China,France,Germany,Italy,Japan,Spain,United Kingdom,and United States for the period2016-2030[J]. J Hepatol,2018,69(4):896-904. [9] ROSQVIST F,IGGMAN D,KULLBERG J,et al. Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans[J]. Diabetes,2014,63(7):2356-2368. [10] RYAN MC,ITSIOPOULOS C,THODIS T,et al. The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease[J]. J Hepatol,2013,59(1):138-143. [11] HEKMATDOOST A,SHAMSIPOUR A,MEIBODI M,et al. Adherence to the Dietary Approaches to Stop Hypertension(DASH)and risk of nonalcoholic fatty liver disease[J]. Int J Food Sci Nutr,2016,67(8):1024-1029. [12] SHIRANI F,SALEHI-ABARGOUEI A,AZADBAKHT L. Effects of Dietary Approaches to Stop Hypertension(DASH)diet on some risk for developing type 2 diabetes:A systematic review and meta-analysis on controlled clinical trials[J]. Nutrition,2013,29(7-8):939-947. [13] MARDINOGLU A,WU H,BJORNSON E,et al. An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans[J]. Cell Metab,2018,27(3):559-571. [14] SCHWIMMER JB,UGALED-NICALO P,WELSH JA,et al.Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys:A randomized clinical trial[J]. JAMA,2019,321(3):256-265. [15] YAN JH,GUAN BJ,GAO HY,et al. Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease:A meta-analysis of randomized controlled trials[J].Medicine(Baltimore),2018,97(37):e12271. [16] SANYAL AJ,ABDELMALEK MF,SUZUKI A,et al. No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial[J].Gastroenterology,2014,147(2):377-384. [17] KRAWCZYK M,MACIEJEWSKA D,RYTERSKA K,et al. Gut permeability might be improved by dietary fiber in individuals with nonalcoholic fatty liver disease(NAFLD)undergoing weight reduction[J]. Nutrients,2018,10(11):e1793. [18] PROMRAT K,KLEINERK DE,NIEMEIER HM,et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis[J]. Hepatology,2010,51(1):121-129. [19] LEUNG C,RIVERA L,FURNESS JB,et al. The role of the gut microbiota in NAFLD[J]. Nat Rev Gastroenterol Hepatol,2016,13(7):412-425. [20] XIA MF,BIAN H,ZHU XP,et al. Serum folic acid levels are associated with the presence and severity of liver steatosis in Chinese adults[J]. Clin Nutr,2018,37(5):1752-1758. [21] RIPPE JM,ANGELOPOULOS TJ. Fructose-containing sugars and cardiovascular disease[J]. Adv Nutr,2015,6(4):430-439. [22] MA J,FOX CS,JACQUES PF,et al. Sugar-sweetened beverage,diet soda,and fatty liver disease in the Framingham Heart Study cohorts[J]. J Hepatol,2015,63(2):462-469. [23] WANG M,ZHANG XJ,FENG K,et al. Dietaryα-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissueliver axis in mice[J]. Sci Rep,2016,6:26826. [24] ANGELICO F,LOFFREDO L,PIGNATELLI P,et al. Weight loss is associated with improved endothelial dysfunction via NOX2-generated oxidative stress down-regulation in patients with the metabolic syndrome[J]. Intern Emerg Med,2012,7(3):219-227. [25] CHAMBERS ES,VIARDOT A,PSICHAS A,et al. Effects of targeted delivery of propionate to the human colon on appetite regulation,body weight maintenance and adiposity in overweight adults[J]. Gut,2015,64(11):1744-1754. [26] CHEN Q,FENG Y,YANG H,et al. A vitamin pattern diet is associated with decreased risk of gestational diabetes mellitus in Chinese women:Results from a case control study in Taiyuan,China[J]. J Diabetes Res,2019,2019:5232308. [27] KWAK MS,KIM D. Non-alcoholic fatty liver disease and lifestyle modifications,focusing on physical activity[J]. Korean J Intern Med,2018,33(1):64-74. [28] ZELBER-SAGI S,BUCH A,YESHUA H,et al. Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial[J]. World J Gastroenterol,2014,20(15):4382-4392. [29] HASHIDA R,KAWAGUCHI T,BEKKI M,et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease:A systematic review[J]. J Hepatol,2017,66(1):142-152. [30] JENSEN MD,RYAN DH,APOVIAN CM,et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults:A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society[J]. J Am Coll Cardiol,2014,63(25 Pt B):2985-3023. [31] WINN NC,LIU Y,RECTOR RS,et al. Energy-matched moderate and high intensity exercise training improves nonalcoholic fatty liver disease risk independent of changes in body mass or abdominal adiposity-A randomized trial[J]. Metabolism,2018,78:128-140. [32] KWAK MS,KIM D,CHUNG GE,et al. Role of physical activity in nonalcoholic fatty liver disease in terms of visceral obesity and insulin resistance[J]. Liver Int,2015,35(3):944-952. [33] KEATING SE,HACKETT DA,PARKER HM,et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity[J]. J Hepatol,2015,63(1):174-182. [34] TSUNODA K,KAI Y,KITANO N,et al. Impact of physical activity on nonalcoholic steatohepatitis in people with nonalcoholic simple fatty liver:A prospective cohort study[J]. Prev Med,2016,88:237-240. [35] LI Y,HE F,HE Y,et al. Dose-response association between physical activity and non-alcoholic fatty liver disease:A case-control study in a Chinese population[J]. BMJ Open,2019,9(3):e026854. [36] ZOU TT,ZHANG C,ZHOU YF,et al. Lifestyle interventions for patients with nonalcoholic fatty liver disease:A network meta-analysis[J]. Eur J Gastroenterol Hepatol,2018,30(7):747-755. [37] KENNEALLY S,SIER JH,MOORE JB. Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease:A systematic review[J]. BMJ Open Gastroenterol,2017,4(1):e000139. [38] GOLABI P,LOCKLEAR CT,AUSTIN P,et al. Effectiveness of exercise in hepatic fat mobilization in non-alcoholic fatty liver disease:Systematic review[J]. World J Gastroenterol,2016,22(27):6318-6327. [39] ECKARD C,COLE R,LOCKWOOD J,et al. Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease:A randomized trial[J]. Therap Adv Gastroenterol,2013,6(4):249-259. [40] KIM D,KIM WR. Nonobese fatty liver disease[J]. Clin Gastroenterol Hepatol,2017,15(4):474-485. [41] WONG VW,CHAN RS,WONG GL,et al. Community-based lifestyle modification programme for non-alcoholic fatty liver disease:A randomized controlled trial[J]. J Hepatol,2013,59(3):536-542.
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