肿瘤坏死因子α诱导蛋白8样分子2在不同肝脏疾病中的免疫调控作用

王闪闪; 张庆山; 赵素贤; 孔令波; 纪雷; 孔丽

doi:10.3969/j.issn.1001-5256.2020.02.050

肿瘤坏死因子α诱导蛋白8样分子2在不同肝脏疾病中的免疫调控作用

DOI: 10.3969/j.issn.1001-5256.2020.02.050

河北医科大学第三医院中西医结合肝病科河北省慢性肝病肝纤维化机制研究重点实验室

基金项目:

河北省卫生厅课题(ZL20140032)；河北省中医药管理局课题(2014142)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2019-09-15
- 出版日期: 2020-02-20

The immunoregulatory effect of tumor necrosis factor-alpha-induced protein 8-like 2 in different liver diseases

Hebei Provincial Key Laboratory for Research on Pathogenesis of Chronic Liver Diseases and Liver Fibrosis,Department of Traditional and Western Medical Hepatology,Third Hospital of Hebei Medical University

Research funding:

摘要

摘要:
肿瘤坏死因子α诱导蛋白8样分子2(TIPE2)可负性调控固有免疫及适应性免疫系统,并通过影响多种信号通路参与肝炎、肝硬化、肝细胞癌等肝脏疾病的发生和发展过程。总结目前TIPE2参与不同肝病发病机制的现有研究,认为TIPE2可能成为治疗不同肝脏疾病的一个新靶点。
- 肝疾病 /
- 肿瘤坏死因子α诱导蛋白8样分子2 /
- 免疫调节
Abstract:
Tumor necrosis factor-alpha-induced protein 8-like 2( TIPE2) can negatively regulate innate immunity and adaptive immunity and participate in the development and progression of various liver diseases,such as hepatitis,liver cirrhosis,and hepatocellular carcinoma,by affecting a variety of signaling pathways. This article summarizes the current research on the involvement of TIPE2 in the pathogenesis of different liver diseases and points out that TIPE2 may become a new target for the treatment of liver diseases.
- liver diseases /
- TIPE2 /
- immunomodulation

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参考文献(33)

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