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免疫控制与慢性乙型肝炎功能性治愈的进展与挑战

郑昕 刘嘉 吴珺 孟忠吉 陆蒙吉 杨东亮

李甜甜, 孙静, 王权, 丁俊强, 王佳, 薛慧, 张弢, 段学章. 小肝癌立体定向放射治疗的效果及预后分析[J]. 临床肝胆病杂志, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
引用本文: 李甜甜, 孙静, 王权, 丁俊强, 王佳, 薛慧, 张弢, 段学章. 小肝癌立体定向放射治疗的效果及预后分析[J]. 临床肝胆病杂志, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
Li TianTian, Sun Jing, Wang Quan, Ding JunQiang, Wang Jia, Xue Hui, Zhang Tao, Duan XueZhang. Clinical effect of stereotactic body radiotherapy in treatment of patients with small hepatocellular carcinoma and related prognostic factors[J]. J Clin Hepatol, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
Citation: Li TianTian, Sun Jing, Wang Quan, Ding JunQiang, Wang Jia, Xue Hui, Zhang Tao, Duan XueZhang. Clinical effect of stereotactic body radiotherapy in treatment of patients with small hepatocellular carcinoma and related prognostic factors[J]. J Clin Hepatol, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.

免疫控制与慢性乙型肝炎功能性治愈的进展与挑战

DOI: 10.3969/j.issn.1001-5256.2020.05.001
基金项目: 

国家自然科学基金(81461130019,81672022,91742114,8181101231,91642118); 国家传染病防治科技重大专项(2017ZX10202202,2017ZX10202201,2017ZX10202203,2018ZX10302206,2018ZX10723203); 

详细信息
  • 中图分类号: R512.62

Advances and challenges in immune control and functional cure of chronic hepatitis B

Research funding: 

 

  • 摘要:

    HBV与宿主免疫系统的相互作用决定了HBV感染的结局。虽然迄今尚无彻底根治乙型肝炎的药物,但是随着研究的深入,以血清HBsAg和HBV DNA持续阴转为特征的"功能性治愈"已成为慢性乙型肝炎的可实现治疗目标。而基于对HBV感染免疫控制机制新认识的免疫调控治疗也成为实现慢性乙型肝炎功能性治愈的重要策略之一。本文仅就HBV感染免疫控制及其在功能性治愈策略研究中应用的进展与存在问题做一简要综述。

     

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