慢性HBV感染者病毒特异性T淋巴细胞：耗竭还是沉默？

王昊亮; 邓国宏

doi:10.3969/j.issn.1001-5256.2020.05.005

慢性HBV感染者病毒特异性T淋巴细胞：耗竭还是沉默？

DOI: 10.3969/j.issn.1001-5256.2020.05.005

陆军军医大学西南医院感染病科，感染病研究重庆市重点实验室

基金项目:

传染病国家科技重大专项（2018ZX10302206）；国家自然科学基金重点项目（81930061）；重庆市自然科学基金（cstc2019jcyj-zdxmX0004,cstc2019jcyj-bshX0039）；

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中图分类号: R512.62
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出版历程
- 出版日期: 2020-05-20

Functional status of hepatitis B virus-specific T cells in patients with chronic hepatitis B virus infection:Exhausted or silenced?

Chongqing Key Laboratory of Infectious Diseases, Department of Infectious Diseases, Southwest Hospital of Army Medical University, Chongqing 400038, China

Research funding:

摘要

摘要:
当前主流观点认为,慢性HBV感染者的病毒特异性T淋巴细胞是处于耗竭状态的T淋巴细胞。总结了以往研究支持该假说的证据,同时对于该假说与临床观察不一致之处提出相应的疑问。综合近期研究结果,认为慢性HBV感染者的病毒特异性T淋巴细胞很可能是分化早期的前体T淋巴细胞占主导,功能上处于沉默而非耗竭状态,并分析了该群T淋巴细胞保持沉默静息状态的可能原因。
- 乙型肝炎病毒 /
- 乙型肝炎,慢性 /
- T淋巴细胞 /
- 免疫耐受
Abstract:
Hepatitis B virus(HBV)-specific T cells in patients with chronic HBV infection are currently acknowledged as exhausted T cells. This article summarizes previous studies which support this hypothesis and then points out several inconsistencies between this hypothesis and clinical observation. Based on recent research findings, it is pointed out that in patients with chronic HBV infection, HBV-specific T cells might be dominated by silenced, early-differentiated progenitor T cells. Also, this article analyzes the possible causes of the silenced status of those T cells.
- hepatitis B virus /
- hepatitis B,chronic /
- T-lymphocytes /
- immune tolerance

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参考文献(31)

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